Alcohol And Its Biomarkers, Dasgupta,Amitava

Автор: Paul C. Guest
Название: Biomarkers and Mental Illness
ISBN: 3319460870 ISBN-13(EAN): 9783319460871
Издательство: Springer
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Цена: 27940.00 T
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Описание: Employing accessible language throughout, this book covers the history of psychiatric research, the current state-of-the art in psychiatric practice, the physiological systems affected by psychiatric illnesses, the whole-body nature of these diseases and the impact that this aspect has on emerging biomarker discoveries. Further, it provides descriptions of the major specific psychiatric disorders and the special challenges regarding the diagnosis and treatment of each. The book concludes with insights into the latest developments in hand-held biomarker test devices, which can provide diagnostic information in less than 15 minutes in point-of-care settings.This book investigates the emerging use of biomarkers in the study of psychiatric diseases, a topic of considerable importance for a broad range of people including researchers, clinicians, psychiatrists, university students and even those whose lives are affected in some way by a psychiatric illness. The last category is hardly trivial, since a staggering one in three people worldwide show the criteria for at least one psychiatric disorder at some point in their lifetime.

Автор: Stearns Vered
Название: Novel Biomarkers in the Continuum of Breast Cancer
ISBN: 3319794345 ISBN-13(EAN): 9783319794341
Издательство: Springer
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Цена: 93160.00 T
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Описание: This volume provides a comprehensive review of established and novel biomarkers across the continuum of breast cancer.

Автор: Dakubo Gabriel D.
Название: Cancer Biomarkers in Body Fluids: Principles
ISBN: 331979129X ISBN-13(EAN): 9783319791296
Издательство: Springer
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Цена: 139750.00 T
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Описание: The molecular and genetic signatures of cancer are represented in the peripheral circulation and other body fluids, giving rise to the “liquid biopsy” concept. This new paradigm of molecular profiling of cancer cells offers several advantages over traditional tissue biopsy. It is convenient, noninvasive, conforms to current clinical practice, enables real time disease monitoring and the study of tumor evolution, can easily be sampled multiple times, and this sample is more representative of the heterogeneous cancer cells than biopsy sampling. Indeed, all aspects of cancer molecular genetic information, stemming from DNA (both nuclear and mitochondria), RNA (coding and noncoding), peptides and proteins, metabolites and lipids are present in body fluids as free, cell surface bound or enclosed in membrane vesicles, and are being harnessed for disease management. Additionally, circulating tumor, and tumor stem cells provide prognostic information, and also enable the study of the intricate molecular processes associated with metastasis and drug resistance. This treatise deals with the general principles of the molecular pathology of cancer, and its associated imprints in circulation. The transitional process from discovery, prototype development, translational research, to product development can be complex and costly. The critical path to biomarker development and qualification for successful use in drug development is detailed herein as well. This book is of interest to Cancer Researchers, Oncologists, Clinicians, Surgeons, Medical Students, Nurses, Diagnostic Laboratories, and Pharmaceutical Industries.

Автор: Jose Luis Garcia-Gimenez
Название: Epigenetic Biomarkers and Diagnostics
ISBN: 0128018992 ISBN-13(EAN): 9780128018996
Издательство: Elsevier Science
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Цена: 108920.00 T
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Описание:

"Epigenetic Biomarkers and Diagnostics" comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders.

The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease.
Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognosticsDescribes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnosticsDiscusses the advances in epigenomics technologies, including next-generation sequencing based tools and applicationsExpounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseasesIncludes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies

Автор: Guest Paul C.
Название: Biomarkers and Mental Illness: It`s Not All in the Mind
ISBN: 3319834371 ISBN-13(EAN): 9783319834375
Издательство: Springer
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Цена: 23280.00 T
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Описание: Employing accessible language throughout, this book covers the history of psychiatric research, the current state-of-the art in psychiatric practice, the physiological systems affected by psychiatric illnesses, the whole-body nature of these diseases and the impact that this aspect has on emerging biomarker discoveries.

Название: Novel biomarkers in the continuum of breast cancer
ISBN: 3319229087 ISBN-13(EAN): 9783319229089
Издательство: Springer
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Цена: 130610.00 T
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Описание: This volume provides a comprehensive review of established and novel biomarkers across the continuum of breast cancer.

Название: Neurodegenerative diseases
ISBN: 3030102890 ISBN-13(EAN): 9783030102890
Издательство: Springer
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Цена: 111790.00 T
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Описание: This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer`s disease, frontotemporal lobar degeneration, Lewy body dementia,Parkinson`s disease, amyotrophic lateral sclerosis, and additional less common neurodegenerative diseases.

Автор: Daniela Galimberti; Elio Scarpini
Название: Neurodegenerative Diseases
ISBN: 1447172426 ISBN-13(EAN): 9781447172420
Издательство: Springer
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Цена: 111790.00 T
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Описание: This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer`s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases.

Автор: Dakubo
Название: Cancer Biomarkers in Body Fluids
ISBN: 3030247236 ISBN-13(EAN): 9783030247232
Издательство: Springer
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Цена: 139750.00 T
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Описание: The ability to measure and monitor cancer biomarkers in "body fluid biopsy" should greatly impact oncologic practice. "Biomarkers in Proximal Fluids", the third of the "Cancer Biomarkers in Body Fluids" series details cancer signatures in none or minimally circulating body fluids including saliva, sputum, bronchoalveolar lavage fluid, exhaled breath condensate, nipple aspirate fluid, gastric and pancreatic juice, stool, urine, and prostatic, peritoneal and cerebrospinal fluid. These fluids are enriched with biomarkers, especially those emanating from cells of the proximal tissue.

Chapter 1 examines the global burden of cancer and the need for regional efforts at primary prevention, early detection and patient care. Chapters 2-12 address tissue-specific biomarkers in associated body fluids. The tumor interstitial fluid as a microenvironment rich in cancer biomarkers is detailed in chapter 13, while chapter 14 looks at the human body fluid microbiome and its evolving role in cancer.

Commercially available assays using proximal fluids are examined at the end of the respective chapters. This book complements its predecessors and is equally useful to oncologists, cancer researchers, clinicians, medical students, nurses, diagnostic laboratory and pharmaceutical industry personnel.

Автор: Yihong Yao
Название: Genomic Biomarkers for Pharmaceutical Development,
ISBN: 0123973368 ISBN-13(EAN): 9780123973368
Издательство: Elsevier Science
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Цена: 74620.00 T
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Описание: Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care. This book provides a complete picture of biomarker development and validation in a pharmaceutical setting while addressing the inherent challenges of targeting the appropriate indications, biomarker robustness, regulatory hurdles, commercialization and much more. It features case studies devoted to the applications of pharmacogenomics, toxicogenomics, and other genetic technologies as they support drug discovery and development. . With chapters written by international authorities in industry and academia, this work is a truly unique presentation of the thoughts and approaches that lead to the development of personalized medicine. Intended for all those involved in clinical translational research, this book is the ideal resource for scientists searching for the applications, strategies and successful approaches of translational science in pharmaceutical development.

Автор: Pallaval Veera Bramhachari; Nageswara Rao Reddy Ne
Название: Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers
ISBN: 9811544301 ISBN-13(EAN): 9789811544309
Издательство: Springer
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Цена: 139750.00 T
Наличие на складе: Невозможна поставка.
Описание: This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers.

Автор: Thomas D`Hooghe
Название: Biomarkers for Endometriosis
ISBN: 3319598546 ISBN-13(EAN): 9783319598543
Издательство: Springer
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Цена: 130430.00 T
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Описание: This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility.