Metabotropic Glutamate Receptors In Psychiatric And Neurological Disorders,168, Knackstedt,Lori

Автор: Philippe Ascher; Dennis W. Choi
Название: Glutamate, Cell Death and Memory
ISBN: 3642845282 ISBN-13(EAN): 9783642845284
Издательство: Springer
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Цена: 121110.00 T
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Описание: As for the proceedings of the meeting on Alzheimer`s disease - published in the series Research and Perspectives in Alzheimer`s disease -these meetings will be reported in a new series, distributed at an international level, Research and Perspectives in Neurosciences.

Автор: Jones, Susan
Название: Dopamine - Glutamate Interactions in the Basal Ganglia
ISBN: 1420088793 ISBN-13(EAN): 9781420088793
Издательство: Taylor&Francis
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Цена: 183750.00 T
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Автор: Jordan OKeeffe
Название: Metabotropic Glutamate Receptors: Classification, Structure and Roles in Disease
ISBN: 153613676X ISBN-13(EAN): 9781536136760
Издательство: Nova Science
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Цена: 122490.00 T
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Описание: Metabotropic Glutamate Receptors: Classification, Structure and Roles in Disease focuses on Glutamate (Glu), a neurotransmitter/neuromodulator the most widely present in neurons of excitatory pathways, both in the central and peripheral nervous system. The authors present and discuss the molecular structure of some glutamatergic receptors, their distribution, specificity and molecular mechanisms of the physiological and pathological effects of Glu in health and illness. The specific and nonspecific agonist/antagonist receptors utility are also discussed. Following this, the recent outcomes on the role of mGlu7 and mGlu8 receptors on pain transmission and affective/cognitive disorders are summarized. Particular emphasis is placed on their modulation within the antinociceptive descending system, an endogenous anatomical substrate whose pharmacological manipulation may strategically silence pain. In the concluding chapter, the authors reviewed the roles of Metabotropic Glutamate Receptors (mGluRs) and their related signal transduction pathways or interacting proteins in the pathogenesis of the status epilepticus and temporal lobe epilepsy. Some novel therapeutical drug targets for controlling epilepsy and epileptogenesis are proposed.

Автор: P. Jeffrey Conn; Jitendra Patel
Название: The Metabotropic Glutamate Receptors
ISBN: 1617370061 ISBN-13(EAN): 9781617370069
Издательство: Springer
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Описание: It is the goal of The Metabotropic Glutamate Receptors to provide acomprehensive and forward-thinking review ofthe tremen- dous advances that have occurred in less than a decade of metabotropic glutamate receptors (mGluR) research. Virtually every areaof mGluR research is covered, including the molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles of mGluRs. It is our intention that this volume not only summarize what is now known about the mGluRs, but also illuminate the areas in which there is the greatest need for focused research. Glutamic acid is an amino acid that has long been known to play several important metabolic roles in central and peripheral tissues and to be a component of several naturally occurring molecules. The first evidence that glutamate mayaIso serve as a neurotransmitter in the central nervous system (CNS) came in the late 1950s and early 1960s when glutamate and other acidic amino acids were found to induce behavioral convulsions when topically applied to the cortex and to excite a wide variety of central neurons. These findings spurred a massive research effort that quickly established glutamate as the pri- mary excitatory neurotransmitter in the vertebrate CNS. One of the most striking characteristics of glutamate that was quickly recognized was its ubiquitous role in serving as the neurotransmitter at the vast majority of excitatory synapses in the brain. It is now clear that most central neuronal circuits involve glutamatergic neurotransmission at some level.

Автор: House, Patrick
Название: Metabotropic Glutamate Receptor Technologies
ISBN: 1071611097 ISBN-13(EAN): 9781071611098
Издательство: Springer
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Цена: 102480.00 T
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Описание: This volume highlights various techniques used to study multiple aspects of mGlu receptor function.

Автор: Olive M. Foster, Burrows Brian T., Leyrer-Jackson Jonna M.
Название: Metabotropic Glutamate Receptor Technologies
ISBN: 1071611062 ISBN-13(EAN): 9781071611067
Издательство: Springer
Цена: 266460.00 T
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Описание: This volume highlights various techniques used to study multiple aspects of mGlu receptor function.

Автор: Senthilkumar Rajagopal; Murugavel Ponnusamy
Название: Metabotropic GPCRs: TGR5 and P2Y Receptors in Health and Diseases
ISBN: 9811315701 ISBN-13(EAN): 9789811315701
Издательство: Springer
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Цена: 93160.00 T
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Описание: This book will provide current understandings about two ubiquitously expressed metabotropic GPCRs, G-coupled purinoreceptor type 2 (P2Y) and Takeda G-protein-coupled bile acid receptor 5 (TGR5). G protein coupled receptors (GPCRs) are the largest family of proteins implicated in majority of cellular responses. The two receptor sub-families play a central role in many physiological functions as well as in many pathological conditions. This book offers up-to-date information on the physiological functions, signaling pathways and regulatory mechanisms of P2Y and TGR5 receptors. In addition, this book provides a comprehensive overview about the abnormalities of P2Y/TGR5 receptors and their contribution in the development and progression of pathological conditions. It also covers the currently available natural, chemical and pharmacological agents targeting these two receptor families and their therapeutic implications in P2Y and TGR5 associated disorders. This book is a valuable source for beginners and researchers to follow the rapidly progressing field of these two GPCR subfamily members.

Автор: Robert W. Gereau; Geoffrey Swanson
Название: The Glutamate Receptors
ISBN: 1627039201 ISBN-13(EAN): 9781627039208
Издательство: Springer
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Цена: 243800.00 T
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Описание: This insightful and comprehensive book covers nearly every aspect of glutamate receptor structure and function for the working researcher and student.

Автор: Daniel Monaghan; Robert Wenthold
Название: The Ionotropic Glutamate Receptors
ISBN: 1461284422 ISBN-13(EAN): 9781461284420
Издательство: Springer
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Цена: 213360.00 T
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Описание: The field of the excitatory amino acids was born when L-glutamate and L-aspartate were found to be potent convulsants (Hayashi, 1954), and were subsequently found to excite neurons directly (Curtis, Phillis, and Watkins, 1959). Although these studies initiated the hypothesis of glutamate-mediated neurotransmission, it was noted that the ubiquitous actions of glutamate could also reflect a general, nonspecific property of glutamate on neuronal mem- branes. It was not until 20 years later that pharmacological, physiological, and biochemical studies provided convincing evidence for a neurotransmitter role for glutamate in the mammalian central nervous system (CNS). With the critical demonstration that the pharmacologically defined glutamate receptors mediate synaptic currents, glutamate rapidly became widely accepted as a majorneurotransmitter by the mid-1980s. This breakthrough, together with the simultaneous findings that glutamate receptors are involved in many essential, as well as pathological, processes in the CNS, instantly transformed the study of glutamate receptors into one of the fastest-growing and most exciting areas of neuroscience. With the cloning of numerous ionotropic glutamate receptor subunits over the last six years, the field has experienced another dramatic acceleration in the understanding of receptor action and in providing the first clear insights into the molecular bases underlying the wealth of pharmacological and physiological data on these receptors.

Автор: Pavlovic Zoran M.
Название: Glutamate and Neuropsychiatric Disorders: Current and Emerging Treatments
ISBN: 3030874796 ISBN-13(EAN): 9783030874797
Издательство: Springer
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Цена: 214280.00 T
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Описание: This volume provides a comprehensive overview of recent advances in targeting glutamate signaling for the treatment of major psychiatric and neurological disorders. It draws on the latest findings in glutamate neurobiology and offers valuable insights into the application of translational principles in neuroscience drug discovery and development. In each chapter, glutamate as a neurotransmitter, its receptors and transporters, and their interplay with other neurotransmitters and neurotrophic factors, are discussed in the context of a specific, highly prevalent and disabling CNS disease. Most recent and detailed information is provided on Ischemic Stroke, Chronic Stress, Major Depressive Disorder, Bipolar Disorder, Autism Spectrum Disorders (ASD), Posttraumatic Stress Disorder (PTSD), Alzheimer’s Dementia, Schizophrenia, Impulsive Aggression, Substance Use Disorders (SUD), Amyotrophic Lateral Sclerosis (ALS), Chronic Pain, Multiple Sclerosis, Parkinson’s Disease, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Epilepsy and Anxiety disorders. Moreover, the book includes an extensive overview of glutamatergic treatments already available on the market, and those which are currently in pharmaceutical drug development pipelines. The primary beneficiaries will be neurology and psychiatry specialists and residents, neuroscientists, neuropharmacologists, pharmaceutical industry and clinical research organization professionals, academics, and clinicians working with psychiatric and neurological patients with comorbidities such as cardiologists, pulmonologists, and endocrinologists. This book will also appeal to psychiatry and neurology subspecialists and clinicians working in neuroscience labs seeking an easy-to-understand yet comprehensive overview of contemporary evidence-based clinical insights backed by basic science (preclinical) research evidence. Given its scope, the book is also a unique and indispensable resource for both preclinical and clinical neuroscientists, medical advisors, and clinical research specialists in the pharmaceutical industry. In addition, it will appeal to neuroscience and neuropsychopharmacology students and guide them through the complexities of glutamate involvement in the pathophysiology of the most common debilitating brain diseases with high unmet medical needs.

Автор: Peter Jonas; Hannah Monyer
Название: Ionotropic Glutamate Receptors in the CNS
ISBN: 3540661204 ISBN-13(EAN): 9783540661207
Издательство: Springer
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Цена: 567410.00 T
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Описание: With contributions by numerous experts

Автор: Pavlovic
Название: Glutamate and Neuropsychiatric Disorders
ISBN: 3030874826 ISBN-13(EAN): 9783030874827
Издательство: Springer
Рейтинг:
Цена: 214280.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides a comprehensive overview of recent advances in targeting glutamate signaling for the treatment of major psychiatric and neurological disorders. It draws on the latest findings in glutamate neurobiology and offers valuable insights into the application of translational principles in neuroscience drug discovery and development. In each chapter, glutamate as a neurotransmitter, its receptors and transporters, and their interplay with other neurotransmitters and neurotrophic factors, are discussed in the context of a specific, highly prevalent and disabling CNS disease. Most recent and detailed information is provided on Ischemic Stroke, Chronic Stress, Major Depressive Disorder, Bipolar Disorder, Autism Spectrum Disorders (ASD), Posttraumatic Stress Disorder (PTSD), Alzheimer’s Dementia, Schizophrenia, Impulsive Aggression, Substance Use Disorders (SUD), Amyotrophic Lateral Sclerosis (ALS), Chronic Pain, Multiple Sclerosis, Parkinson’s Disease, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Epilepsy and Anxiety disorders. Moreover, the book includes an extensive overview of glutamatergic treatments already available on the market, and those which are currently in pharmaceutical drug development pipelines. The primary beneficiaries will be neurology and psychiatry specialists and residents, neuroscientists, neuropharmacologists, pharmaceutical industry and clinical research organization professionals, academics, and clinicians working with psychiatric and neurological patients with comorbidities such as cardiologists, pulmonologists, and endocrinologists. This book will also appeal to psychiatry and neurology subspecialists and clinicians working in neuroscience labs seeking an easy-to-understand yet comprehensive overview of contemporary evidence-based clinical insights backed by basic science (preclinical) research evidence. Given its scope, the book is also a unique and indispensable resource for both preclinical and clinical neuroscientists, medical advisors, and clinical research specialists in the pharmaceutical industry. In addition, it will appeal to neuroscience and neuropsychopharmacology students and guide them through the complexities of glutamate involvement in the pathophysiology of the most common debilitating brain diseases with high unmet medical needs.