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Glutamate and Neuropsychiatric Disorders, Pavlovic


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Автор: Pavlovic
Название:  Glutamate and Neuropsychiatric Disorders
ISBN: 9783030874827
Издательство: Springer
Классификация:




ISBN-10: 3030874826
Обложка/Формат: Soft cover
Страницы: 600
Вес: 0.96 кг.
Дата издания: 26.04.2023
Язык: English
Издание: 1st ed. 2022
Иллюстрации: 35 tables, color; 40 illustrations, color; 3 illustrations, black and white; xxxv, 600 p. 43 illus., 40 illus. in color.
Размер: 235 x 155
Читательская аудитория: Professional & vocational
Основная тема: Biomedicine
Подзаголовок: Current and Emerging Treatments
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This volume provides a comprehensive overview of recent advances in targeting glutamate signaling for the treatment of major psychiatric and neurological disorders. It draws on the latest findings in glutamate neurobiology and offers valuable insights into the application of translational principles in neuroscience drug discovery and development. In each chapter, glutamate as a neurotransmitter, its receptors and transporters, and their interplay with other neurotransmitters and neurotrophic factors, are discussed in the context of a specific, highly prevalent and disabling CNS disease. Most recent and detailed information is provided on Ischemic Stroke, Chronic Stress, Major Depressive Disorder, Bipolar Disorder, Autism Spectrum Disorders (ASD), Posttraumatic Stress Disorder (PTSD), Alzheimer’s Dementia, Schizophrenia, Impulsive Aggression, Substance Use Disorders (SUD), Amyotrophic Lateral Sclerosis (ALS), Chronic Pain, Multiple Sclerosis, Parkinson’s Disease, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Epilepsy and Anxiety disorders. Moreover, the book includes an extensive overview of glutamatergic treatments already available on the market, and those which are currently in pharmaceutical drug development pipelines. The primary beneficiaries will be neurology and psychiatry specialists and residents, neuroscientists, neuropharmacologists, pharmaceutical industry and clinical research organization professionals, academics, and clinicians working with psychiatric and neurological patients with comorbidities such as cardiologists, pulmonologists, and endocrinologists. This book will also appeal to psychiatry and neurology subspecialists and clinicians working in neuroscience labs seeking an easy-to-understand yet comprehensive overview of contemporary evidence-based clinical insights backed by basic science (preclinical) research evidence. Given its scope, the book is also a unique and indispensable resource for both preclinical and clinical neuroscientists, medical advisors, and clinical research specialists in the pharmaceutical industry. In addition, it will appeal to neuroscience and neuropsychopharmacology students and guide them through the complexities of glutamate involvement in the pathophysiology of the most common debilitating brain diseases with high unmet medical needs.
Дополнительное описание: Treatments Against Glutamatergic Excitotoxicity in Ischemic Stroke.- Definitions and Concepts of Stress.- Role of Glutamatergic Neurotransmission in the Pathophysiology of Stress-Related Disorders and Chronic Stress Response.- Current Glutamatergic Treatm


Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders

Автор: Weizman
Название: Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders
ISBN: 9048177383 ISBN-13(EAN): 9789048177387
Издательство: Springer
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Цена: 269260.00 T
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Описание: This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders. It addresses the neurosteroid function in brain development and plasticity, in both the normal and the pathological brain.

Transgenic and Knockout Models of Neuropsychiatric Disorders

Автор: Gene S. Fisch; Jonathan Flint
Название: Transgenic and Knockout Models of Neuropsychiatric Disorders
ISBN: 1617376078 ISBN-13(EAN): 9781617376078
Издательство: Springer
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Цена: 231990.00 T
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Описание: In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond.

Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders

Автор: Popoli
Название: Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders
ISBN: 1493910558 ISBN-13(EAN): 9781493910557
Издательство: Springer
Цена: 149060.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:

1. The Brain on Stress: The Good and the Bad
Bruce S. McEwen

2. Regulation of Excitatory Synapses by Stress Hormones
Marian Joлls, Harm Krugers, Henk Karst

3. Synaptic Stress, Changes in Glutamate Transmission and Circuitry, and Psychopatology
Laura Musazzi, Giulia Treccani, Carla Perego, Nicoletta Nava, Jens R Nyengaard, Maurizio Popoli

4. Dual Regulation of Glutamatergic Transmission and Cognition by Stress in Prefrontal Cortex Zhen Yan

5. Role of Endocannabinoids in Regulating Glucocorticoid Effects on Memory for Emotionally Arousing Experiences
Piray Atsak, Benno Roozendaal, Patrizia Campolongo

6. Endocannabinoid Signaling & Synaptic Plasticity During Stress
J. Megan Gray, Haley A. Vecchiarelli, Matthew N. Hill

7. Stress Induced Metaplasticity at GABA Synapses
Jaideep S. Bains

8. Stress Modulation of Synaptic Plasticity in the Hippocampus
Menahem Segal, Nicola Maggio

9. Neural-Cognitive Effects of Stress in the Hippocampus
Jeansok J. Kim, Blake A. Pellman, Eun Joo Kim

10. Evolutionary, Historical and Mechanistic Perspectives on How Stress Affects Memory and Hippocampal Synaptic Plasticity
George E. Farmer, Collin R. Park, Laura A. Bullard, David M. Diamond

11. Acute Stress Disrupts Short- and Long-term Patterns of Synaptic Plasticity in Dorsal Hippocampus and Subiculum: Implications for Hippocampal Output and Behaviour
John G. Howland, Don A. Davies

12. Synaptic Mechanisms and Cognitive Computations Underlying Stress Effects on Cognitive Function
Gediminas Luksys, Carmen Sandi

13. Altered GABA Function in Major Depression
Beverly French, Marianne L. Seney, Etienne Sibille

14. Pathology in Astroglia, Glutamate and GABA in Major Depressive Disorder: Evidence from Studies of Human Postmortem Tissue
Grazyna Rajkowska

15. Evidence of Glutamatergic Dysfunction in the Pathophysiology of SchizophreniaJ.C. Hammond, D. Shan, J.H. Meador-Woodruff, R.E. McCullumsmith

16. Metabolic Stress and Neuropsychiatric Disorders
Claudia A. Grillo, Lawrence P. Reagan

17. Using our Understanding of Stress Related Effects on Glutamate Neurotransmission to Guide the Development of Novel Treatment Strategies
Carly Kiselycznyk, Gerard Sanacora


Neuropsychiatric Disorders and Epigenetics

Автор: Yasui, Dag
Название: Neuropsychiatric Disorders and Epigenetics
ISBN: 0128002263 ISBN-13(EAN): 9780128002261
Издательство: Elsevier Science
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Цена: 93200.00 T
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Описание:

Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease.

Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development.

  • Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction
  • Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists
  • Extensive use of diagrams, illustrations, tables, and graphical abstracts for each section providing rapid assessment

Staging Neuropsychiatric Disorders

Автор: Tom?s Palomo; Richard M. Kostrzewa; Richard J. Ben
Название: Staging Neuropsychiatric Disorders
ISBN: 148999646X ISBN-13(EAN): 9781489996466
Издательство: Springer
Рейтинг:
Цена: 174130.00 T
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Описание: This book features chapters by participants of the International Meeting on Staging Neuropsychiatric Disorders: Implications for Etiopathogenesis and Treatment. It highlights prevention and treatment strategies at different stages of disease progression.

Staging Neuropsychiatric Disorders

Автор: Tom?s Palomo; Richard M. Kostrzewa; Richard J. Ben
Название: Staging Neuropsychiatric Disorders
ISBN: 1489986847 ISBN-13(EAN): 9781489986849
Издательство: Springer
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Цена: 149060.00 T
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Описание: Book chapters are authored by participants in the International Meeting on Staging Neuropsychiatric Disorders: Implications for Etiopathogenesis and Treatment, held in Moj?car (Almer?a) Spain from 14-18 October 2009. Chapters are organized into four sections on themes encompassed by Staging Neuropsychiatric Disorders: Clinical Staging in the Pathophysiology of Psychotic and Affective Disorders, Staging Perspectives in Neurodevelopmental Aspects of Neuropsychiatry, Epigenetics and Biomarkers in the Staging of Neuropsychiatric Disorders, and Staging Neurodegenerative Disorders. This volume should serve as a resource for physicians and neuroscientists alike, highlighting the importance of staging neuropsychiatric disorders and the underlying mechanistic dysfunction, for prevention and treatment strategies at different stages of disease progression. Earlier volumes in the series, published by the Fundaci?n Cerebro y Mente in Madrid, Spain: Depressive, Anxiety and Drug Abuse Disorders Eds: T. Palomo and T. Archer Schizophrenia, Movement Disorders and Age Related Cognitive Disorders Eds.: T. Palomo, T. Archer and R.J. Beninger Dopamine Disease States Eds.: R.J. Beninger, T. Palomo and T. Archer Interactive Monoaminergic Disorders Eds.: T. Palomo, R.J. Beninger and T. Archer Neurodegenerative Brain Disorders Eds.: T. Palomo, R.J. Beninger and T. Archer Neurodevelopmental Liabilities in Brain Disease States Eds.: R.J. Beninger, T. Palomo, R.M. Kostrzewa and T. Archer Gene-Environment Interplay in Brain Disease States Eds.: T. Palomo, R.J. Beninger, R.M. Kostrzewa and T. Archer Implications of CoMorbidity for Etiology and Treatment of Neuropsychiatric Disorders Eds.: T. Palomo, R.J. Beninger, R.M. Kostrzewa and T. Archer Beyond Neuropsychiatric Diagnostics: Symptoms not Disorders Eds.: T. Palomo, R.J. Beninger, R.M. Kostrzewa and T. Archer

Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders

Автор: Maurizio Popoli; David Diamond; Gerard Sanacora
Название: Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders
ISBN: 1493946323 ISBN-13(EAN): 9781493946327
Издательство: Springer
Рейтинг:
Цена: 130590.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent studies show that changes in Glutamate/GABA synapses and related pathways may determine whether the synaptic plasticity that occurs as a response to stress is adaptive or maladaptive.

Anhedonia: A Comprehensive Handbook Volume II

Автор: Michael S. Ritsner
Название: Anhedonia: A Comprehensive Handbook Volume II
ISBN: 9402403000 ISBN-13(EAN): 9789402403008
Издательство: Springer
Рейтинг:
Цена: 130430.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This is the first comprehensive two-volume collection on anhedonia, a disorder that played an important role in psychopathology theories at the beginning of the twentieth century. Anhedonia is a condition in which the capacity of pleasure is partially or completely lost, and it refers to both a personality trait, and a “state symptom” in various neuropsychiatric and physical disorders. It has a putative neural substrate, originating in the dopaminergic mesolimbic and mesocortical reward circuit. Over the past three decades cognitive psychology and behavioral neuroscience have expanded our understanding of anhedonia and other reward-related processes. The aim of this new two-volume collection on anhedonia is to highlight the contributions of eminent scientists in this field as well as to provide readers with comprehensive accounts of recent developments as perceived by the authors. This monograph is divided into five parts. Volume I contains parts one and two (Conceptual Issues and Neurobiological Advances) including 14 chapters that serve as an introduction and overview of conceptual issues. Volume II contains three parts (Anhedonia in Psychotic Disorders, Anhedonia in Mood and Personality Disorders, and Anhedonia in Neurological and Physical Disorders) including 15 chapters that provide an overview of the construct, measurement of anhedonia in schizophrenia spectrum disorders, hedonic capacity and related factors in schizophrenia and schizoaffective disorder, anhedonia as an indicator of genetic liability for schizophrenia, and as a trait marker for depression, the role of an anhedonia in trauma-related disorders, anorexia nervosa, stress-induced eating disorders, schizotypal traits and risk of suicide. This book will be of interest to a broad spectrum of readers including psychiatrists, psychologists, neurologists, neuroscientists, endocrinologists, pharmacologists, general practitioners, geriatricians, graduate students, and health care providers in the fields of mental health.

Neuropsychiatric Symptoms of Movement Disorders

Автор: Heinz Reichmann
Название: Neuropsychiatric Symptoms of Movement Disorders
ISBN: 3319351761 ISBN-13(EAN): 9783319351766
Издательство: Springer
Рейтинг:
Цена: 111790.00 T
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Описание:

Depression, Apathy, Anhedonia, Fatigue in Parkinson's Disease.- Mild Cognitive Impairment in Parkinson's Disease.- Parkinson's Disease Dementia.- Impulse Control Disorders.- Influence of Dietary Constituents on Motor and Non-Motor Symptoms in Parkinson's Disease.- Psychosis in Parkinson's Disease.- Neuropsychiatric Manifestations in Atypical Parkinsonian Syndromes.- Neuropsychiatric Disturbances in Dystonia.- Depression in Huntington's Disease.- Cognitive Impairment and Dementia (Mild or Major Neurocognitive Disorder) in Huntington's Disease.- Tics.- Wilson's Disease.- Ataxia.


Neuroimaging in child neuropsychiatric disorders

Автор: B. Garreau
Название: Neuroimaging in child neuropsychiatric disorders
ISBN: 3642958508 ISBN-13(EAN): 9783642958502
Издательство: Springer
Рейтинг:
Цена: 93160.00 T
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Описание: The twentieth century was the century of the development of morphological cerebral imaging by tomodensitometry (TDM) and Magnetic Resonance Imaging (MRI).

Transcranial Direct Current Stimulation in Neuropsychiatric Disorders

Автор: Andr? Brunoni; Michael Nitsche; Colleen Loo
Название: Transcranial Direct Current Stimulation in Neuropsychiatric Disorders
ISBN: 331981642X ISBN-13(EAN): 9783319816425
Издательство: Springer
Рейтинг:
Цена: 93160.00 T
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Описание: The aim of this book is to provide a comprehensive review of the use of Transcranial Direct Current Stimulation (tDCS) in different psychiatric conditions. Here we review tDCS clinical studies employing different types of design (from single-session tDCS studies to randomized clinical trials) as well as studies evaluating the impact of tDCS in neurophysiological, behavioral and brain imaging outcomes.Although the understanding about physiological foundations and effectiveness of clinical therapies of psychiatric diseases has been considerably increased during the last decades, our knowledge is still limited, and consequently psychiatric diseases are still a major burden to the individual patient and society. Recently, interest in pathological alterations of neuroplasticity in psychiatric diseases as a critical condition for development, and amelioration of clinical symptoms increased, caused by the fact that new tools, such as functional imaging, and brain stimulation techniques do allow to monitor, and modulate these phenomena in humans. Especially non-invasive brain stimulation techniques evolved as an attractive potential new therapeutic tool. The interest in non-invasive brain stimulation has grown exponentially in the past 25 years, with the development of non-pharmacological, neuromodulatory techniques such as tDCS and repetitive transcranial magnetic stimulation (rTMS). TDCS, although even newer than rTMS, has attracted considerable attention in both basic and clinical research scenarios. In the context of clinical research, tDCS is being increasingly investigated as a novel treatment tool for several psychiatric disorders, such as major depression, schizophrenia and neurocognitive and substance abuse disorders.Transcranial Direct Current Stimulation in Neuropsychiatric Disorders – Clinical Principles and Management intends to serve as a practical guide on the field, attracting the interest of psychiatrists, neurologists and neuroscientists with little or no experience with tDCS, as well as those with a background on tDCS who want to increase their knowledge in any particular psychiatric condition.

Molecular Basis Of Neuropsychiatric Disorders: From Bench To Bedside,167

Автор: Rahman, Shafiqur
Название: Molecular Basis Of Neuropsychiatric Disorders: From Bench To Bedside,167
ISBN: 0128188553 ISBN-13(EAN): 9780128188552
Издательство: Elsevier Science
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Цена: 150470.00 T
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Описание:

Progress in Molecular Biology and Translational Science, Volume 167, provides the most topical, informative and exciting monographs available on a wide variety of research topics related to Models and Biological Targets in Drug Discovery for Attention Deficit Hyperactivity Disorder, Novel Targets for Parkinson-Depression Co-morbidity. Utility of Cannabidiol (CBD) in Neuropsychiatric Disorders: A Short Review of the Recent Pre-clinical and Clinical Findings, The Many Sides of Microglia in Alcohol Use Disorders, Stress, Anxiety, Molecular Targets and More, Calcineurin Signaling in Psychiatric Disorders, Emerging Evidence for the Role of Pituitary Adenylate Cyclase- Activating Peptide (PACAP) in Neuropsychiatric Disorders, and more.



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