Автор: James W. Larrick; C. Borrebaeck Название: Therapeutic Monoclonal Antibodies ISBN: 1349118966 ISBN-13(EAN): 9781349118960 Издательство: Springer Рейтинг: Цена: 104480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A review of therapeutic antibodies which have commercial potential. It discusses PCR cloning of Igs, immortalization by gene transfer, scale up production, infectious diseases, viruses, bacteria, parisites, inflammation/immunology, blood grouping, cells, cytokines, tumours and MDR.
Автор: Kaur, Harleen Название: Monoclonal Antibodies ISBN: 0128223189 ISBN-13(EAN): 9780128223185 Издательство: Elsevier Science Рейтинг: Цена: 153830.00 T Наличие на складе: Невозможна поставка. Описание:
Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments for complex diseases and creating more affordable healthcare alternatives. Developing mAbs into well-characterized antibody therapeutics that meet regulatory expectations, however, is extremely challenging. Obstacles to overcome include the determination and development of physiochemical characteristics such as aggregation, fragmentation, charge variants, identity, carbohydrate structure, and higher-order structure (HOS).
This book dives deep into mAbs structure and the array of physiochemical testing and characterization methods that need to be developed and validated to establish a mAb as a therapeutic molecule. The main focus of this book is on physiochemical aspects, including the importance of establishing quality attributes such as glycosylation, primary sequence, purity, and HOS and elucidating the structure of new antibody formats by mass spectrometry. Each of the aforementioned quality attributes has been discussed in detail; this will help scientists in researching and developing biopharmaceuticals and biosimilars to find practical solutions to physicochemical testing and characterization.
Автор: Martin Rosenberg; R. Balint; Gordon P. Moore; C.F. Название: The Pharmacology of Monoclonal Antibodies ISBN: 3642784348 ISBN-13(EAN): 9783642784347 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This rapidly-evolving field has witnessed the PCR combinatorial cloning of vast immunological diversity, in vitro mutagenesis of MAbs, MAbs created by transgenic animals, novel expression systems in plants, animals and lower systems, as well as a rich variety of genetically modified MAbs as potential therapeutic agents.
Автор: Shire,Steven Название: Monoclonal Antibodies ISBN: 0081002963 ISBN-13(EAN): 9780081002964 Издательство: Elsevier Science Рейтинг: Цена: 162820.00 T Наличие на складе: Поставка под заказ.
Автор: G. Subramanian Название: Antibodies ISBN: 1461347025 ISBN-13(EAN): 9781461347026 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Both the nature of monoclonal antibody therapies and the relatively large size of the monoclonal antibody dictate the production requirements, for many ofthese therapeutics the monoclonal antibody product will be 100 kilogrammes or more per year.
Автор: John Landon; Tim Chard Название: Therapeutic Antibodies ISBN: 1447119398 ISBN-13(EAN): 9781447119395 Издательство: Springer Рейтинг: Цена: 95770.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Several aspects of clinical medicine are poised on the edge of a new era with the introduction of therapeutic antibodies. This volume is aimed at all clinicians involved with this form of treatment, especially accident and emergency physicians, clinical immunologists, and pharmacologists.
Автор: Antony S. Dimitrov (Ed.) Название: Therapeutic Antibodies ISBN: 1934115924 ISBN-13(EAN): 9781934115923 Издательство: Springer Рейтинг: Цена: 204970.00 T Наличие на складе: Нет в наличии. Описание: Presents a set of protocols for the discovery and development of therapeutic antibodies, featuring sections focusing on recombinant antigens, antibody libraries, antibody discovery, antibody engineering and antibody preclinical development. This work is suitable for those investigating and participating in this therapeutic market segment.
Автор: Chernajovsky Название: Therapeutic Antibodies ISBN: 3540732586 ISBN-13(EAN): 9783540732587 Издательство: Springer Рейтинг: Цена: 330870.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: With contributions by numerous experts
Автор: Houen Название: Therapeutic Antibodies ISBN: 1071614495 ISBN-13(EAN): 9781071614495 Издательство: Springer Рейтинг: Цена: 107130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This detailed book covers methods for studying, producing, and analyzing therapeutic antibodies, measuring their concentration, developing neutralizing antibodies for them, and for predicting and monitoring their therapeutic efficacy and clinical effects. These biologics are the fastest growing pharmaceutical drug group and have had tremendous clinical and scientific impact in cancer, autoimmune diseases, infectious diseases, and other immune-related diseases, making the content of this volume essential. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible methods, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Therapeutic Antibodies: Methods and Protocols serves as an ideal guide for researchers working with the production of, research on, and development of therapeutic antibodies as well as for clinicians using therapeutic antibodies in daily work with patients.
Автор: Houen Название: Therapeutic Antibodies ISBN: 1071614525 ISBN-13(EAN): 9781071614525 Издательство: Springer Рейтинг: Цена: 107130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This detailed book covers methods for studying, producing, and analyzing therapeutic antibodies, measuring their concentration, developing neutralizing antibodies for them, and for predicting and monitoring their therapeutic efficacy and clinical effects. These biologics are the fastest growing pharmaceutical drug group and have had tremendous clinical and scientific impact in cancer, autoimmune diseases, infectious diseases, and other immune-related diseases, making the content of this volume essential. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible methods, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Therapeutic Antibodies: Methods and Protocols serves as an ideal guide for researchers working with the production of, research on, and development of therapeutic antibodies as well as for clinicians using therapeutic antibodies in daily work with patients.
Автор: G. Subramanian Название: Antibodies ISBN: 0306483157 ISBN-13(EAN): 9780306483158 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Brings to the forefront the advances in novel technologies for the manufacturing of monoclonal antibodies and also their clinical importance. This volume focusses on: technologies in the manufacture of monoclonal antibodies, the application of antibodies in cancer therapy and functional genomic therapy, and the importance of antibodies.
Автор: Elkordy, Amal Ali (professor Of Pharmaceutics, Faculty Of Health Sciences And Wellbeing, School Of Pharmacy And Pharmaceutical Sciences, University Of Название: Formulation of monoclonal antibody therapies ISBN: 0128233656 ISBN-13(EAN): 9780128233658 Издательство: Elsevier Science Рейтинг: Цена: 153830.00 T Наличие на складе: Поставка под заказ.
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