Plants produce secondary metabolites that humans harness for their own benefit. About half of drugs currently in clinical use are based on these chemicals found in nature. Chemistry of Natural Products covers secondary metabolites present in medicinal plants and their biosynthesis, biological activities, and isolation and separation techniques. This book is ideal for researchers in the areas of biochemistry, medicine, and pharmacology.
Автор: Wang Название: Predictive ADMET: Integrated Approaches in Drug Discovery and Development ISBN: 1118299922 ISBN-13(EAN): 9781118299920 Издательство: Wiley Рейтинг: Цена: 142510.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: By guiding in the application of techniques and tools for predicting ADMET outcomes in drug candidates, Predictive ADMET offers a road map for drug discovery scientists to generate effective and safe drugs for unmet medical needs.
Автор: Sandeep Kumar Название: Developability of Biotherapeutics: Computational Approaches ISBN: 1482246139 ISBN-13(EAN): 9781482246131 Издательство: Taylor&Francis Рейтинг: Цена: 163330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Biopharmaceuticals are emerging as frontline medicines to combat several life-threatening and chronic diseases. However, such medicines are expensive to develop and produce on a commercial scale, contributing to rising healthcare costs. Developability of Biotherapeutics: Computational Approaches describes applications of computational and molecular modeling techniques that improve the overall process of discovery and development by removing empiricism.
The concept of developability involves making rational choices at the pre-clinical stages of biopharmaceutical drug development that could positively impact clinical outcomes. The book also addresses a general lack of awareness of the many different contributions that computation can make to biopharmaceutical drug development.
This informative and practical reference is a valuable resource for professionals engaged in industrial research and development, scientists working with regulatory agencies, and pharmacy, medicine, and life science students and educators. It focuses primarily on the developability of monoclonal antibody candidates, but the principles described can also be extended to other modalities such as recombinant proteins, fusion proteins, antibody drug conjugates and vaccines.
The book is organized into two sections. The first discusses principles and applications of computational approaches toward discovering and developing biopharmaceutical drugs. The second presents best practices in developability assessments of early-stage biopharmaceutical drug candidates.
In addition to raising awareness of the promise of computational research, this book also discusses solutions required to improve the success rate of translating biologic drug candidates into products available in the clinic. As such, it is a rich source of information on current principles and practices as well as a starting point for finding innovative applications of computation towards biopharmaceutical drug development.
Автор: Rajni Miglani Bhardwaj Название: Control and Prediction of Solid-State of Pharmaceuticals ISBN: 3319275542 ISBN-13(EAN): 9783319275543 Издательство: Springer Рейтинг: Цена: 121890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Another important section involves looking at the influence of small changes in structure and substituents on solid-structure and diversity using computational tools including crystal structure prediction, PIXEL calculations, Xpac, Mercury and statistical modeling tools.
Автор: P.W. Codding Название: Structure-Based Drug Design ISBN: 0792352017 ISBN-13(EAN): 9780792352013 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Brings together scientists working on different aspects of structure-based drug design and demonstrates the necessary collaboration and interdisciplinary approach to this area. This book focuses on X-ray crystallographic and computational approaches. It provides examples of the application of X-ray crystallography and molecular modelling.
Автор: Pal, Sarbani Название: Isocoumarin, Thiaisocoumarin and Phosphaisocoumarin ISBN: 012815411X ISBN-13(EAN): 9780128154113 Издательство: Elsevier Science Рейтинг: Цена: 163940.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Isocoumarin, Thiaisocoumarin and Phosphaisocoumarin: Natural Occurrences, Synthetic Approaches and Pharmaceutical Applications gives an overview of the various aspects of this class of heterocycle, with a major focus on synthesis and biological activity. Aromatic δ lactones or isocoumarins with thiaisocoumarins, phosphaisocoumarins and a-pyranone fused with a heteroaryl ring constitute an important class of heterocyclic compounds. This book provides the methods applied for the synthesis of thiaisocoumarins, phosphaisocoumarins, and a-pyranone fused with a heteroaryl ring. It is useful to medicinal and natural product chemists who want to synthesize target molecules and develop cutting-edge technologies to provide better solutions to researchers.
Features an overview of isocoumarins and their role in pharmaceutical research
Presents a template for the design, discovery and development of new and potential drugs in various therapeutic areas
Includes comprehensive coverage of the synthesis of isocoumarins, from traditional methods, to transition metal catalyzed methods
Looks at future applications for these important compounds in the areas of drug discovery and pharmaceutical research
Автор: Torok, Marianna Название: Contemporary Chemical Approaches For Green And Sustainable Drugs ISBN: 0128222484 ISBN-13(EAN): 9780128222485 Издательство: Elsevier Science Рейтинг: Цена: 220090.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Now the most wanted person in Sonande, her only hope of reclaiming what is rightfully hers lies in a divine power hidden in the long-lost city of her ancestors. Meanwhile, the resurrection of Karina`s sister has spiraled the world into chaos, with disaster after disaster threatening the hard-won peace Malik has found as Farid`s apprentice.
Автор: de Lange Название: Drug Delivery to the Brain ISBN: 3030887723 ISBN-13(EAN): 9783030887728 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood–brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiological considerations written specifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.
Автор: Patrick, Graham L. Название: An Introduction to Medicinal Chemistry ISBN: 0199234477 ISBN-13(EAN): 9780199234479 Издательство: Oxford Academ Рейтинг: Цена: 29560.00 T Наличие на складе: Нет в наличии. Описание: Assuming minimum background knowledge, the book develops an understanding of the molecular function of drugs and how they interact with the body, before exploring drug discovery and development. It goes on to examine topical issues in applications of medicinal chemistry to novel drug design, to give a contemporary view of the field.
Автор: Katja Strohfeldt-Venables Название: Essentials of Inorganic Chemistry: For Students of Pharmacy, Pharmaceutical Sciences and Medicinal Chemistry.- Wiley, 2015 ISBN: 0470665580 ISBN-13(EAN): 9780470665589 Издательство: Wiley Рейтинг: Цена: 49580.00 T Наличие на складе: Поставка под заказ. Описание: A comprehensive introduction to inorganic chemistry and, specifically, the science of metal-based drugs, Essentials of Inorganic Chemistry describes the basics of inorganic chemistry, including organometallic chemistry and radiochemistry, from a pharmaceutical perspective.
Автор: Watson, David G. (Senior Lecturer in Pharmaceutical Sciences, Strathclyde Institute of Pharmaceutical and Biomedical Sciences, University of Strathcly Название: Pharmaceutical and Medicinal Chemistry. Elsevier,2011 ISBN: 9780443072321\Давид Уотсон:Фармацевтическая и лекарственная химия, Элзивир,2011 ISBN: 0443072329 ISBN-13(EAN): 9780443072321 Издательство: Elsevier Science Рейтинг: Цена: 49390.00 T Наличие на складе: Поставка под заказ. Описание: Intends to define the area of pharmaceutical chemistry as distinct from medicinal chemistry. This book emphasizes on the physicochemical properties of drug molecules and, in so far as they are known, the way that these properties govern the interaction of the drug with its target.
Автор: Vivekkumar K Redasani Название: Prodrug Design ISBN: 0128035196 ISBN-13(EAN): 9780128035191 Издательство: Elsevier Science Рейтинг: Цена: 41530.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry provides a focused overview of this critical area of drug discovery, as that continuous process strives not only to discover new drug compounds but also to modify the existing ones. This valuable primer supports this mission of drug development and its goal of reducing undesired effects and improving therapeutic effectiveness of drug compounds. Providing a unique compilation of data, insightful case studies, and review of existing literature in the area, the book will promote innovation in medicinal and pharmaceutical chemistry research, exploring the limitations of existing drugs and their improvement. Prodrug Design reviews marketed compounds, the safety of promoieties, and a detailed classification of prodrugs organized by therapeutic area for easy reference.
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