Staging Neuropsychiatric Disorders, Tom?s Palomo; Richard M. Kostrzewa; Richard J. Ben
Автор: Yasui, Dag Название: Neuropsychiatric Disorders and Epigenetics ISBN: 0128002263 ISBN-13(EAN): 9780128002261 Издательство: Elsevier Science Рейтинг: Цена: 93200.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease.
Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development.
Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction
Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists
Extensive use of diagrams, illustrations, tables, and graphical abstracts for each section providing rapid assessment
Автор: Maurizio Popoli; David Diamond; Gerard Sanacora Название: Synaptic Stress and Pathogenesis of Neuropsychiatric Disorders ISBN: 1493946323 ISBN-13(EAN): 9781493946327 Издательство: Springer Рейтинг: Цена: 130590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Recent studies show that changes in Glutamate/GABA synapses and related pathways may determine whether the synaptic plasticity that occurs as a response to stress is adaptive or maladaptive.
Автор: Tom?s Palomo; Richard M. Kostrzewa; Richard J. Ben Название: Staging Neuropsychiatric Disorders ISBN: 148999646X ISBN-13(EAN): 9781489996466 Издательство: Springer Рейтинг: Цена: 174130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book features chapters by participants of the International Meeting on Staging Neuropsychiatric Disorders: Implications for Etiopathogenesis and Treatment. It highlights prevention and treatment strategies at different stages of disease progression.
Автор: Weizman Название: Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders ISBN: 9048177383 ISBN-13(EAN): 9789048177387 Издательство: Springer Рейтинг: Цена: 269260.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders. It addresses the neurosteroid function in brain development and plasticity, in both the normal and the pathological brain.
Автор: F. Owen; R. Itzhaki Название: Molecular and Cell Biology of Neuropsychiatric Diseases ISBN: 9401043051 ISBN-13(EAN): 9789401043052 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: is''0l m 5-HT Ante-mortem (m = metabolite) . ." Post-mortem m 0 Noradrenaline, -'-'-'-'0-J, -'-'-'-'-'-'- m Dopamine . '-'-'-'-'- . " Somatostatin . '1 Plaques Tangles * . ." . ." . 'I Synapse loss * ChAT " ACh synthesis l"-, . '-'-'-'-'-'-'-'-'-'-'-'-'-, -'-'-'-'-'-'-'-'-'-'-'-'-'-'- * Neuronal loss, -, - . ." * o 0. 1 0. 2 0. 3 0. 4 0. 5 0. 6 0. 7 0. 8 0. 9 1. 0 Correlation coefficient with dementia rating Figure 2. 1 Various neurotransmitter and neuropathological measures on neocortex obtained either at diagnostic craniotomy (ante-mortem) or post-mortem and re- lationship to cognitive impairment (dementia rating). Asterisks identify significant correlations. Negative and positive correlations are not identified in this represen- tation of the data. Only the physiologically relevant measure of cholinergic neurones (acetylcholine synthesis) and indices of cortical pyramidal neurone degeneration (neuronal loss, synapse loss and tangles) correlate with severity of dementia. Note the lack of correlation with the structural marker of cholinergic neurones, ChAT activity. Loss of enzyme exceeded that of acetylcholine synthesis (Sims et al., 1983a), suggesting a compensatory increase in synthesis in the few remaining neurones. Data derived from Palmer (1987) and Terry et al. (1991). emission tomography (PET) and magnetic resonance, may some day pro- vide routine insight into differences in brain functioning. Success in developing rapid and reliable diagnostic procedures, perhaps based on changes in body fluid that reflect specific alterations in brain protein metabolism, should ultimately play an important role in the clinical development of new therapeutic agents.
Автор: Gene S. Fisch; Jonathan Flint Название: Transgenic and Knockout Models of Neuropsychiatric Disorders ISBN: 1617376078 ISBN-13(EAN): 9781617376078 Издательство: Springer Рейтинг: Цена: 231990.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond.
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