Non-clinical Statistics in Drug Discovery, Crimin, Kimberly

Автор: Zammitt Nicola
Название: Essentials of Kumar and Clark`s Clinical Medicine,7 ed. IE
ISBN: 0702082805 ISBN-13(EAN): 9780702082801
Издательство: Elsevier Science
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Цена: 24550.00 T
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Описание: AVAILABLE TO PREORDER NOWFrom the bestselling and Booker Prize winning author of Never Let me Go and The Remains of the Day, a stunning new novel - his first since winning the Nobel Prize in Literature - that asks, what does it mean to love? A thrilling feat of world-building, a novel of exquisite tenderness and impeccable restraint, Klara and the Sun is a magnificent achievement, and an international literary event.

Автор: Gill, Denis O`Brien, Niall
Название: Paediatric Clinical Examination Made Easy 6E IE (Pediatric)
ISBN: 0702072893 ISBN-13(EAN): 9780702072895
Издательство: Elsevier Science
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Цена: 18660.00 T
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Описание: "For over a century and in scores of countries, patriarchal presumptions and practices have been challenged by women and their male allies. "Sexual harassment" has entered common parlance; police departments are equipped with rape kits; more than half of the national legislators in Bolivia and Rwanda are women; and a woman candidate won the plurality of the popular votes in the 2016 United States presidential election. But have we really reached equality and overthrown a patriarchal point of view? The Big Push exposes how patriarchal ideas and relationships continue to be modernized to this day. Through contemporary cases and reports, renowned political scientist Cynthia Enloe exposes the workings of everyday patriarchy--in how Syrian women civil society activists have been excluded from international peace negotiations; how sexual harassment became institutionally accepted within major news organizations; or in how the UN Secretary General`s post has remained a masculine domain. Enloe then lays out strategies and skills for challenging patriarchal attitudes and operations. Encouraging self-reflection, she guides us in the discomforting curiosity of reviewing our own personal complicity in sustaining patriarchy in order to withdraw our own support for it. Timely and globally conscious, The Big Push is a call for feminist self-reflection and strategic action with a belief that exposure complements resistance."--Provided by publisher.

Автор: Van Wyhe John
Название: Wanderlust: The Amazing Ida Pfeiffer, the First Female Tourist
ISBN: 9813250763 ISBN-13(EAN): 9789813250765
Издательство: Mare Nostrum (Eurospan)
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Цена: 18390.00 T
Наличие на складе: Невозможна поставка.
Описание: The true story of Ida Pfeiffer (1797-1858), one of the most remarkable female travellers who ever lived - a housewife who decided to follow her dreams despite the strong disapproval of society. Hers is a tale that culminates in spies, intrigue, a botched revolution and a remarkable career cut tragically short by one voyage too many.

Автор: Bonnel Wanda, Smith Katharine
Название: Proposal Writing for Clinical Nursing and DNP Projects
ISBN: 082614442X ISBN-13(EAN): 9780826144423
Издательство: Mare Nostrum (Eurospan)
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Цена: 35110.00 T
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Описание: Through her illuminating and detailed analyses of both the Reagan presidency and many blockbuster movies, Susan Jeffords provides a scenario within which the successes of the New Right and the Reagan presidency can begin to be understood: she both encourages an understanding of how this complicity functioned and provides a framework within which to respond to the New Right`s methods and arguments.

Автор: Ali Mousavi
Название: Persepolis: Discovery and Afterlife of a World Wonder
ISBN: 1614510288 ISBN-13(EAN): 9781614510284
Издательство: Walter de Gruyter
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Цена: 161100.00 T
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Описание: Persepolis: Discovery and Afterlife of a World Wonder presents the first full study of the history of archaeological exploration at Persepolis after its destruction in 330 BC.

Автор: Major, R.H.
Название: India in the Fifteenth Century
ISBN: 1409412881 ISBN-13(EAN): 9781409412885
Издательство: Taylor&Francis
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Цена: 137810.00 T
Наличие на складе: Нет в наличии.
Описание: The volume contains the following accounts, edited, with an introduction: Narrative of the voyage of Abd-er-Razzak, Ambassador from Shah Rukh, A.H. 845, A.D. 1442.; The travels of Nicolo Conti in the East in the early part of the fifteenth century; The travels of Athanasius Nikitin, a native of Twer; The journey of Hieronimo di Santo Stefano, a Genoese.

This is a new print-on-demand hardback edition of the volume first published in 1857.

Автор: Louise Ryan,Umut Erel,Alessio D`Angelo
Название: Migrant Capital: Networks, Identities and Strategies
ISBN: 1137348798 ISBN-13(EAN): 9781137348791
Издательство: Springer
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Цена: 74530.00 T
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Описание: Migrant Capital presents state-of-the-art empirical, theoretical and methodological perspectives on migration, networks, social and cultural capital, exploring the ways in which these bodies of literature can inform and strengthen each other. In so doing,

Автор: Strauss
Название: Making Sense of Public Opinion
ISBN: 1107688698 ISBN-13(EAN): 9781107688698
Издательство: Cambridge Academ
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Цена: 52790.00 T
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Описание: Claudia Strauss proposes that Americans form views on immigration and social welfare programs from conventional ways of speaking rather than from liberal or conservative ideologies. This book explains what conventional discourses are, how to study them and why they are fundamental elements of public opinion and political culture.

Автор: Amador Jose
Название: Medicine and Nation Building in the Americas, 1890-1940
ISBN: 0826520200 ISBN-13(EAN): 9780826520203
Издательство: Mare Nostrum (Eurospan)
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Цена: 76690.00 T
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Описание: As medical science progressed through the nineteenth century, the US was at the forefront of public health initiatives across the Americas. This wasn`t a purely altruistic enterprise, however, as Jose Amador reveals in Medicine and Nation Building in the Americas, 1890-1940. Rather, these efforts almost served as a precursor to modern American interventionism.

Автор: Shay Soker; Aleksander Skardal
Название: Tumor Organoids
ISBN: 3319605097 ISBN-13(EAN): 9783319605098
Издательство: Springer
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Цена: 158380.00 T
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Описание: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

Автор: Sadao Nagaoka
Название: Drug Discovery in Japan
ISBN: 9811389055 ISBN-13(EAN): 9789811389054
Издательство: Springer
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Цена: 74530.00 T
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Описание: This book analyzes the drug-discovery process in Japan, based on detailed case studies of 12 groups of 15 innovative drugs. It covers the first statin in the world up to the recent major breakthrough in cancer therapy, the recent immune checkpoint inhibitor, the scientific discovery for which a 2018 Nobel Prize in Physiology or Medicine was awarded to Prof. Tasuku Honjo, Kyoto University. The book shows the pervasive high uncertainty in drug discovery: frequent occurrences of unexpected difficulties, discontinuations, serendipities, and good luck, significantly because drug discovery starts when the underlying science is incomplete. Thus, there exist dynamic interactions between scientific progress and drug discovery. High uncertainty also makes the value of an entrepreneurial scientist high. Such scientists fill the knowledge gaps by absorbing external scientific progress and by relentless pursuit of possibilities through their own research, often including unauthorized research, to overcome crises. Further, high uncertainty and its resolution significantly characterize the evolution of competition in the drug industry. The patent system promotes innovation under high uncertainty not only by enhancing appropriability of R&D investment but also by facilitating the combination of knowledge and capabilities among different firms through disclosure. Understanding such a process significantly benefits the creation of innovation management and policy practices.

Автор: Alexander G. Ramm
Название: Inverse Obstacle Scattering with Non-Over-Determined Scattering Data
ISBN: 1681735903 ISBN-13(EAN): 9781681735900
Издательство: Mare Nostrum (Eurospan)
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Цена: 57290.00 T
Наличие на складе: Поставка под заказ.
Описание: Kalman J. Kaplan and Paul Cantz offer a biblically-based approach to suicide prevention, designed to overcome suicidogenic patterns in fourteen patients fitting into seven Graeco-Roman suicidal syndromes. Kaplan and Cantz use biblical narratives alongside an in-depth positive psychology, aimed at promoting life instead of simply preventing suicide.