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Drug Discovery in Japan, Sadao Nagaoka


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Автор: Sadao Nagaoka
Название:  Drug Discovery in Japan
ISBN: 9789811389054
Издательство: Springer
Классификация:


ISBN-10: 9811389055
Обложка/Формат: Hardcover
Страницы: 333
Вес: 0.69 кг.
Дата издания: 2019
Язык: English
Издание: 1st ed. 2019
Иллюстрации: 50 tables, color; 32 illustrations, color; 24 illustrations, black and white; xii, 370 p. 56 illus., 32 illus. in color.
Размер: 234 x 156 x 21
Читательская аудитория: Professional & vocational
Основная тема: Economics
Подзаголовок: Investigating the sources of innovations
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This book analyzes the drug-discovery process in Japan, based on detailed case studies of 12 groups of 15 innovative drugs. It covers the first statin in the world up to the recent major breakthrough in cancer therapy, the recent immune checkpoint inhibitor, the scientific discovery for which a 2018 Nobel Prize in Physiology or Medicine was awarded to Prof. Tasuku Honjo, Kyoto University. The book shows the pervasive high uncertainty in drug discovery: frequent occurrences of unexpected difficulties, discontinuations, serendipities, and good luck, significantly because drug discovery starts when the underlying science is incomplete. Thus, there exist dynamic interactions between scientific progress and drug discovery. High uncertainty also makes the value of an entrepreneurial scientist high. Such scientists fill the knowledge gaps by absorbing external scientific progress and by relentless pursuit of possibilities through their own research, often including unauthorized research, to overcome crises. Further, high uncertainty and its resolution significantly characterize the evolution of competition in the drug industry. The patent system promotes innovation under high uncertainty not only by enhancing appropriability of R&D investment but also by facilitating the combination of knowledge and capabilities among different firms through disclosure. Understanding such a process significantly benefits the creation of innovation management and policy practices.
Дополнительное описание: Foreword.- Acknowledgement.- Chapter 1: Introduction.- Chapter 2: Compactin.- Chapter 3: Pravastatin (Pravachol, Mevalotin).- Chapter 4: Rosuvastatin(Crestor).- Chapter 5: Leuprorelin (Leuplin, Lupron, Viadur).- Chapter 6: Oflaxacin and levofloxacin (Tari


Account of a Voyage of Discovery to the West Coast of Corea, and the Great Loo-Choo Island

Автор: Hall
Название: Account of a Voyage of Discovery to the West Coast of Corea, and the Great Loo-Choo Island
ISBN: 1108080421 ISBN-13(EAN): 9781108080422
Издательство: Cambridge Academ
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Цена: 48570.00 T
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Описание: Basil Hall (1788-1844) commanded the brig HMS Lyra as part of Lord Amherst`s 1816 embassy to the Qing court in China. This 1818 account describes the mission`s visits to the west coast of Korea and to Okinawa. Richly illustrated, the book describes the local cultures, languages and geography.

Wanderlust: The Amazing Ida Pfeiffer, the First Female Tourist

Автор: Van Wyhe John
Название: Wanderlust: The Amazing Ida Pfeiffer, the First Female Tourist
ISBN: 9813250763 ISBN-13(EAN): 9789813250765
Издательство: Mare Nostrum (Eurospan)
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Цена: 18390.00 T
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Описание: The true story of Ida Pfeiffer (1797-1858), one of the most remarkable female travellers who ever lived - a housewife who decided to follow her dreams despite the strong disapproval of society. Hers is a tale that culminates in spies, intrigue, a botched revolution and a remarkable career cut tragically short by one voyage too many.

The Last Journey of the San Bao Eunuch, Admiral Zheng He

Автор: Sheng-Wei Wang
Название: The Last Journey of the San Bao Eunuch, Admiral Zheng He
ISBN: 9888491660 ISBN-13(EAN): 9789888491667
Издательство: Mare Nostrum (Eurospan)
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Цена: 58210.00 T
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Описание: Suggested navigational routes, timelines and evidence relating to the seventh (and last) voyage of Admiral Zheng He have been extracted for the first time, from a 1597 volume entitled An Account of the Western World Voyage of the San Bao Eunuch by Luo Maodeng. From 1405, in order to maintain and expand the Ming Dynasty’s tributary system, Yongle Emperor Zhu Di and Xuande Emperor Zhu Zhanji ordered eunuch Zheng He to lead giant fleets across the seas. But soon after Zheng He’s seventh and last voyage in the 1430s, the Ming emperors put an end to this activity and ordered all records of previous voyages to be destroyed. Chinese writer Luo Maodeng, knowing the history of some of these voyages, wished to preserve a record of them, but, conscious of the possible penalty, decided to record the facts ‘under a veil’, in his 1597 novel. This volume shows the derivation of the complete trans-Atlantic navigational routes and timelines of that last journey, and presents the idea that Zheng He’s last expedition plausibly reached the ancient American Indian city, Cahokia, in the U.S. central Mississippi Valley in late autumn, 1433, long before Christopher Columbus set foot for the first time in the Americas. It supports the hotly debated view that Ming Chinese sailors and ships reached farther than previously accepted in modern times and calls for further research, bridging the gap in our understanding of ancient China-America history and the era before the Age of Discovery.

In the ‘Wild Countries` of Central Asia: Ethnography, Science, and Empire in Imperial Russia

Автор: Scott Bailey
Название: In the ‘Wild Countries` of Central Asia: Ethnography, Science, and Empire in Imperial Russia
ISBN: 1680530879 ISBN-13(EAN): 9781680530872
Издательство: Mare Nostrum (Eurospan)
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Цена: 117000.00 T
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Описание: In this stimulating and timely book, Scott Bailey, an American teaching Russian and Eurasian history in Japan, traces the history of the dynamic Russian Geographical Society, which carried out major research expeditions to Central Eurasia during the second half of the nineteenth century. The immediate goal of its expeditions was to collect ethnographic, geographic, and natural-scientific information on these regions and their peoples. Their wider benefits established and extended Russia’s imperial control in Central Eurasia, including some regions under direct or indirect Chinese control. These expeditions served the acquisition of social and scientific information to benefit the Russian Empire’s colonization efforts. Their leaders were often elites trained in ethnography, geography, and natural science subjects, and a major objective of this book is to give a fuller picture of the diverse biographies of these figures, not all of whom were Russian or European males.In the ‘Wild Countries’ moves chronologically from the founding of the Russian Geographical Society in 1845 to the beginning of the revolutionary period in Russia in 1905. During these decades, research missions became more overtly “imperial” and coincided with the consolidation of Russian hegemony over Central Eurasia and an increasing Russian interest in territories in the western and northern regions of the Chinese Q’ing Empire. The book also addresses wider moves toward imperial projects worldwide.

Richard Halliburton and the Voyage of the Sea Dragon

Автор: Gerald Max
Название: Richard Halliburton and the Voyage of the Sea Dragon
ISBN: 1621905764 ISBN-13(EAN): 9781621905769
Издательство: Mare Nostrum (Eurospan)
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Цена: 29220.00 T
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Описание: Richard Halliburton (1900–1939), considered the world’s first celebrity travel writer, swam the length of the Panama Canal, recreated Ulysses’ voyages in the Mediterranean, crossed the Alps on an elephant, flew around the world in a biplane, and descended into the Mayan Well of Death, all the while chronicling his own adventures. Several books treat his life and travels, yet no book has addressed in detail Halliburton’s most ambitious expedition: an attempt to sail across the Pacific Ocean in a Chinese junk.Set against the backdrop of a China devastated by invading Japanese armies and the storm clouds of world war gathering in Europe, Halliburton and a crew of fourteen set out to build and sail the Sea Dragon—a junk or ancient sailing ship—from Hong Kong to San Francisco for the Golden Gate International Exposition. After battling through crew conflicts and frequent delays, the Sea Dragon set sail on March 4, 1939. Three weeks after embarking, the ship encountered a typhoon and disappeared without a trace.Richly enhanced with historic photographs, Richard Halliburton and the Voyage of the Sea Dragon follows the dramatic arc of this ill-fated expedition in fine detail. Gerry Max artfully unpacks the tensions between Halliburton and his captain, John Wenlock Welch (owing much to Welch’s homophobia and Halliburton’s unconcealed homosexuality). And while Max naturally explores the trials and tribulations of preparing, constructing, and finally launching the Sea Dragon, he also punctuates the story with the invasion of China by the Japanese, as Halliburton and his letters home reveal an excellent wartime reporter. Max mines these documents, many of which have only recently come to light, as well as additional letters from Halliburton and his crew to family and friends, photographs, films, and tape recordings, to paint an intricate portrait of Halliburton’s final expedition from inception to tragic end.

Advances in Natural Computation, Fuzzy Systems and Knowledge Discovery

Автор: Yong Liu; Lipo Wang; Liang Zhao; Zhengtao Yu
Название: Advances in Natural Computation, Fuzzy Systems and Knowledge Discovery
ISBN: 3030324559 ISBN-13(EAN): 9783030324551
Издательство: Springer
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Цена: 232910.00 T
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Описание: Presenting selected, peer-reviewed papers from the 15th International Conference on Natural Computation, Fuzzy Systems and Knowledge Discovery (ICNC-FSKD 2019), held in Kunming, China, from 20 to 22 July 2019, it is a useful resource for researchers, including professors and graduate students, as well as R&D staff in industry.

Machine Learning and Knowledge Discovery in Databases

Автор: Michele Berlingerio; Francesco Bonchi; Thomas G?rt
Название: Machine Learning and Knowledge Discovery in Databases
ISBN: 3030109240 ISBN-13(EAN): 9783030109240
Издательство: Springer
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Цена: 46570.00 T
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Описание: The three volume proceedings LNAI 11051 - 11053 constitutes the refereed proceedings of the European Conference on Machine Learning and Knowledge Discovery in Databases, ECML PKDD 2018, held in Dublin, Ireland, in September 2018. Part III: ADS data science applications;

Kerr`s Voyages Series 1: Europe, Asia and the Middle East

Автор: Robert Kerr
Название: Kerr`s Voyages Series 1: Europe, Asia and the Middle East
ISBN: 184885613X ISBN-13(EAN): 9781848856134
Издательство: Bloomsbury Academic
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Цена: 633600.00 T
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Описание: A truly comprehensive account of sea and land voyages, covering a thousand years of exploration from the ninth century to the epic voyages of Captain Cook. With an introduction by a leading scholar this handsome 5 volume set presents Kerr`s outstanding achievement in a unique and informative way.

Internet Naming and Discovery

Автор: Joud S. Khoury; Chaouki T. Abdallah
Название: Internet Naming and Discovery
ISBN: 1447161777 ISBN-13(EAN): 9781447161776
Издательство: Springer
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Цена: 111790.00 T
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Описание: This book explores problems of internet discovery and compact routing as well as the concept of stretch and its relevance to service differentiation, and offers discovery scheme designs that provide different service levels to different sets of entities.

Interdependencies in the Discovery and Adoption of Facebook Applications

Автор: Philip Mayrhofer
Название: Interdependencies in the Discovery and Adoption of Facebook Applications
ISBN: 3834938866 ISBN-13(EAN): 9783834938862
Издательство: Springer
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Цена: 46570.00 T
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Описание: Facebook Platform is a prominent example of an internet-based service for which third-party developers can offer small add-on programs, which are often referred to as applications. This title examines the market for Facebook applications.

Persian Christians at the Chinese Court: The Xi`an Stele and the Early Medieval Church of the East

Автор: R. Todd Godwin
Название: Persian Christians at the Chinese Court: The Xi`an Stele and the Early Medieval Church of the East
ISBN: 1838600132 ISBN-13(EAN): 9781838600136
Издательство: Bloomsbury Academic
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Цена: 35890.00 T
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Описание: The Xi'an Stele, erected in Tang China's capital in 781, describes in both Syriac and Chinese the existence of Christian communities in northern China. While scholars have so far considered the Stele exclusively in relation to the Chinese cultural and historical context, Todd Godwin here demonstrates that it can only be fully understood by reconstructing the complex connections that existed between the Church of the East, Sasanian aristocratic culture and the Tang Empire (617-907) between the fall of the Sasanian Persian Empire (225-651) and the birth of the Abbasid Caliphate (762-1258). Through close textual re-analysis of the Stele and by drawing on ancient sources in Syriac, Greek, Arabic and Chinese, Godwin demonstrates that Tang China (617-907) was a cosmopolitan milieu where multiple religious traditions, namely Buddhism, Zoroastrianism, Manichaeism and Christianity, formed zones of elite culture. Syriac Christianity in fact remained powerful in Persia throughout the period, and Christianity - not Zoroastrianism - was officially regarded by the Tang government as 'The Persian Religion'.Persian Christians at the Chinese Court uncovers the role played by Syriac Christianity in the economic and cultural integration of late Sasanian Iran and China, and is important reading for all scholars of the Church of the East, China and the Middle East in the medieval period.

Persepolis: Discovery and Afterlife of a World Wonder

Автор: Ali Mousavi
Название: Persepolis: Discovery and Afterlife of a World Wonder
ISBN: 1614510288 ISBN-13(EAN): 9781614510284
Издательство: Walter de Gruyter
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Цена: 161100.00 T
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Описание: Persepolis: Discovery and Afterlife of a World Wonder presents the first full study of the history of archaeological exploration at Persepolis after its destruction in 330 BC.


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