For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder their efficacy. Providing practical guidelines for implementing preferred gas and liquid chromatographic methods, Advances in Chromatographic Techniques for Therapeutic Drug Monitoring is a comprehensive reference describing the theory and application of therapeutic drug monitoring in clinical laboratories.
Edited by a distinguished authority in the field and containing contributions from a variety of experts, the book discusses preanalytical variables, the pitfalls of immunoassays, tandem mass spectrometry, issues related to pain management and herbal supplements, and therapeutic drug monitoring for a range of medications, including:
Anticonvulsants
Digitalis
Cardioactive drugs
Antidepressants
Immunosuppressants
Anti-cancer drugs
Vancomycin and aminoglycosides
Antibiotics
Antiretroviral drugs
Nonnarcotic analgesics
Anti-inflammatory drugs
Examing older and newer drugs, the book contains detailed discussions on the rationale for therapeutic drug monitoring of each class of drugs, along with their basic pharmacology and toxicology. An extensive list of references is provided at the end of each chapter so that those interested in implementing a new drug assay can find the most appropriate method for the intended drug.
Автор: D. Stevenson; I.D. Wilson Название: Recent Advances in Chiral Separations ISBN: 146848284X ISBN-13(EAN): 9781468482843 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of a Chromatographic Society International Symposium, held at the University of Surrey, Guildford, UK, September 12-15, 1989
Автор: Gary K. Webster, Laila Knott Название: Chromatographic Methods Development ISBN: 9814800538 ISBN-13(EAN): 9789814800532 Издательство: Taylor&Francis Рейтинг: Цена: 141890.00 T Наличие на складе: Невозможна поставка. Описание: This book is a comprehensive compilation of modern and cutting-edge chromatographic techniques written by pharmaceutical industry experts, academics and vendors in the field. This book is an inclusive guide to developing chromatographic methods for liquid chromatography.
Автор: Harvey Название: Advances in Drug Discovery Techniques ISBN: 0471975095 ISBN-13(EAN): 9780471975090 Издательство: Taylor&Francis Рейтинг: Цена: 0.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A guide to techniques for the discovery and evaluation of pharamcologically active compounds for therapeutic development, this book covers rational drug design, high-throughput screening, and genetic approaches to drug discovery. The authors focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. They examine typical screening studies and their link to robotics and informatics in detail and present an overview of current progress within anitsense therapeutics. The book explores the rapid changes in drug discovery resulting from developments in molecular biology, robotics, and informatics.
Автор: Donald M. Wieland; Michael C. Tobes; Thomas J. Man Название: Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry ISBN: 1461293316 ISBN-13(EAN): 9781461293316 Издательство: Springer Рейтинг: Цена: 104480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Updated and Expanded Versions of Presentations at a Symposium Held June 4, 1984, in Los Angeles, California
Автор: Hildebert Wagner; Rudolf Bauer; Dieter Melchart; P Название: Chromatographic Fingerprint Analysis of Herbal Medicines Volume III ISBN: 3319356208 ISBN-13(EAN): 9783319356204 Издательство: Springer Рейтинг: Цена: 204970.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Volume III of this manual provides an overview of the analytical investigation of 23 additional Chinese Herbal Drugs, which are most commonly used in Traditional Chinese Medicine. Together with Volumes I and II this current volume represents the most comprehensive overview to analytical studies of those herbal drugs. The quality proof of the investigation meets the standard of the European Drug Regulatory Authority. The authors refer to the bioactive constituents, pharmacological and biological activities of all single herbal drugs, as well as their therapeutic applications. Analytical methods applied are described in detail.
Автор: Dasgupta, Amitava Название: Therapeutic Drug Monitoring ISBN: 0123854679 ISBN-13(EAN): 9780123854674 Издательство: Elsevier Science Рейтинг: Цена: 140360.00 T Наличие на складе: Поставка под заказ. Описание: Features topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This title presents advanced techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs.
Автор: Hempel, Georg Название: Methods of Therapeutic Drug Monitoring including Pharmacogenetics ISBN: 0444640665 ISBN-13(EAN): 9780444640666 Издательство: Elsevier Science Рейтинг: Цена: 196510.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Methods of Therapeutic Drug Monitoring including Pharmacogenetics, Second Edition, the 6th volume in the Handbook of Analytical Separations series, covers all aspects of drug monitoring including laboratory work, pharmacokinetic analysis, and clinical aspects. This enables readers from different fields--from the physician on the ward to the analytical chemist--to understand the whole process of therapeutic drug monitoring and to avoid common pitfalls which can arise in all steps of the process.
The new edition contains updated information on analytical techniques for the quantification of drugs as well as pharmacogenetic and pharmacogenomic methods. Recent improvements in column technology for liquid chromatography are covered, as is the use of mass spectroscopy as a detector for all chargeable compounds, which is becoming affordable for many laboratories. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. Coverage has been expanded to drugs new to the market, such as tyrosine kinase inhibitors in oncology and the monitoring of immunosuppressant drugs. The chapter on pharmacokinetic methods is also now streamlined to focus on the applied statistical methods in order to clearly explain the procedures and possible pitfalls.
Unique interdisciplinary approach appeals to a wide range of users, ensuring more successful drug monitoring applications in a number of clinical environments
Each chapter is written by an author from an international lab, providing a global perspective that can be applied in various regulatory environments
Features additional therapeutic drugs to reflect the rising number of immunocompromised patients
Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories
Автор: Adamovics, John A. Название: Chromatographic Analysis of Pharmaceuticals ISBN: 0824797760 ISBN-13(EAN): 9780824797768 Издательство: Taylor&Francis Рейтинг: Цена: 331760.00 T Наличие на складе: Нет в наличии.
Автор: Stoll, Dwight R. Название: Multi-Dimensional Liquid Chromatography ISBN: 036754766X ISBN-13(EAN): 9780367547660 Издательство: Taylor&Francis Рейтинг: Цена: 193950.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Amponsah Название: Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology ISBN: 3031123972 ISBN-13(EAN): 9783031123979 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; 1. Analytical techniques in TDM and clinical toxicology 2. TDM and pharmacokinetic studies 3. TDM of drugs with narrow therapeutic indices 4. Artificial intelligence in TDM and clinical toxicology 5. Future directions and challenges
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