Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology, Amponsah
Автор: Hempel, Georg Название: Methods of Therapeutic Drug Monitoring including Pharmacogenetics ISBN: 0444640665 ISBN-13(EAN): 9780444640666 Издательство: Elsevier Science Рейтинг: Цена: 196510.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Methods of Therapeutic Drug Monitoring including Pharmacogenetics, Second Edition, the 6th volume in the Handbook of Analytical Separations series, covers all aspects of drug monitoring including laboratory work, pharmacokinetic analysis, and clinical aspects. This enables readers from different fields--from the physician on the ward to the analytical chemist--to understand the whole process of therapeutic drug monitoring and to avoid common pitfalls which can arise in all steps of the process.
The new edition contains updated information on analytical techniques for the quantification of drugs as well as pharmacogenetic and pharmacogenomic methods. Recent improvements in column technology for liquid chromatography are covered, as is the use of mass spectroscopy as a detector for all chargeable compounds, which is becoming affordable for many laboratories. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. Coverage has been expanded to drugs new to the market, such as tyrosine kinase inhibitors in oncology and the monitoring of immunosuppressant drugs. The chapter on pharmacokinetic methods is also now streamlined to focus on the applied statistical methods in order to clearly explain the procedures and possible pitfalls.
Unique interdisciplinary approach appeals to a wide range of users, ensuring more successful drug monitoring applications in a number of clinical environments
Each chapter is written by an author from an international lab, providing a global perspective that can be applied in various regulatory environments
Features additional therapeutic drugs to reflect the rising number of immunocompromised patients
Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories
For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder their efficacy. Providing practical guidelines for implementing preferred gas and liquid chromatographic methods, Advances in Chromatographic Techniques for Therapeutic Drug Monitoring is a comprehensive reference describing the theory and application of therapeutic drug monitoring in clinical laboratories.
Edited by a distinguished authority in the field and containing contributions from a variety of experts, the book discusses preanalytical variables, the pitfalls of immunoassays, tandem mass spectrometry, issues related to pain management and herbal supplements, and therapeutic drug monitoring for a range of medications, including:
Anticonvulsants
Digitalis
Cardioactive drugs
Antidepressants
Immunosuppressants
Anti-cancer drugs
Vancomycin and aminoglycosides
Antibiotics
Antiretroviral drugs
Nonnarcotic analgesics
Anti-inflammatory drugs
Examing older and newer drugs, the book contains detailed discussions on the rationale for therapeutic drug monitoring of each class of drugs, along with their basic pharmacology and toxicology. An extensive list of references is provided at the end of each chapter so that those interested in implementing a new drug assay can find the most appropriate method for the intended drug.
Автор: James M. Anderson; Sung Wan Kim Название: Recent Advances in Drug Delivery Systems ISBN: 1461297001 ISBN-13(EAN): 9781461297000 Издательство: Springer Рейтинг: Цена: 104480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of an international symposium held in Park City, Utah, March 2-4, 1983
Автор: Toshiharu Nagatsu; Abraham Fisher; Mitsuo Yoshida Название: Basic, Clinical, and Therapeutic Aspects of Alzheimer`s and Parkinson`s Diseases ISBN: 1468458469 ISBN-13(EAN): 9781468458466 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the Second International Conference held in Kyoto, Japan, November 6-10, 1989
Автор: Toshiharu Nagatsu; Abraham Fisher; Mitsuo Yoshida Название: Basic, Clinical, and Therapeutic Aspects of Alzheimer`s and Parkinson`s Diseases ISBN: 1468458493 ISBN-13(EAN): 9781468458497 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the Second International Conference held in Kyoto, Japan, November 6-10, 1989
Автор: Keservani Raj K., Sharma Anil K., Kesharwani Rajesh Kumar Название: Recent Advances in Drug Delivery Technology ISBN: 152250754X ISBN-13(EAN): 9781522507543 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 179740.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Technological innovations have become the impetus for continuous developments in medical research. With the assistance of new technologies, effective drug delivery techniques have been improved for optimal patient care.Recent Advances in Drug Delivery Technology is a pivotal reference source for the latest scholarly research on the application of pharmaceutical technology to optimize techniques for drug delivery in patients. Focusing on novel approaches in pharmaceutical science, this book is ideally designed for medical practitioners, upper-level students, scientists, and researchers.
Автор: K. D. Rainsford; M. C. Powanda; M. W. Whitehouse Название: Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases ISBN: 3034809263 ISBN-13(EAN): 9783034809269 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In recent years there have been a number of significant developments of natural products for the treatment of rheumatic diseases, pain and gastro-intestinal ulcers and inflammation. The volume covers some of these novel developments of natural products which are of current and future interest as therapies for the above-mentioned conditions. Most available volumes cover a wide range of biological and technicological aspects of natural products and their discovery, some involving synthesis and properties of chemical compounds. The difference in this volume is that the natural products have a focus on their therapeutic effects on pain, arthritic and gastrointestinal diseases. Some of the natural products covered are either at the experimental stage of development while others are well-established clinically-used products. Each has its own unique place in therapy.
Автор: Alamgir Название: Therapeutic Use of Medicinal Plants and their Extracts: Volume 2 ISBN: 3319923862 ISBN-13(EAN): 9783319923864 Издательство: Springer Рейтинг: Цена: 144410.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book starts with a general introduction to phytochemistry, followed by chapters on plant constituents, their origins and chemistry, but also discussing animal-, microorganism- and mineral-based drugs. Further chapters cover vitamins, food additives and excipients as well as xenobiotics and poisons. The book also explores the herbal approach to disease management and molecular pharmacognosy and introduces methods of qualitative and quantitative analysis of plant constituents.Phytochemicals are classified as primary (e.g. carbohydrates, lipids, amino acid derivations, etc.) or secondary (e.g. alkaloids, terpenes and terpenoids, phenolic compounds, glycosides, etc.) metabolites according to their metabolic route of origin, chemical structure and function. A wide variety of primary and secondary phytochemicals are present in medicinal plants, some of which are active phytomedicines and some of which are pharmaceutical excipients.
Автор: Dasgupta, Amitava Название: Therapeutic Drug Monitoring ISBN: 0123854679 ISBN-13(EAN): 9780123854674 Издательство: Elsevier Science Рейтинг: Цена: 140360.00 T Наличие на складе: Поставка под заказ. Описание: Features topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This title presents advanced techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs.
Автор: Marc Galanter Название: Recent Developments in Alcoholism ISBN: 1489916504 ISBN-13(EAN): 9781489916501 Издательство: Springer Рейтинг: Цена: 174150.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Corrado L. Galli; Luigi Manzo; Peter S. Spencer Название: Recent Advances in Nervous System Toxicology ISBN: 1461282292 ISBN-13(EAN): 9781461282297 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume addresses some facets of the adverse actions of chemical agents on the central and peripheral nervous systems in developing and mature states. Some substances perturb ion channels or synaptic mechanisms required for the orderly transfer of electrochemical information within the nervous system.
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