Biomarkers of Toxic Metals, Lopes de Andrade, Vanda M

Автор: Kewal K. Jain
Название: The Handbook of Biomarkers
ISBN: 1627038361 ISBN-13(EAN): 9781627038362
Издательство: Springer
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Цена: 144410.00 T
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Описание: Of the thousands of biomarkers that are currently being discovered, relatively few are being validated for further applications, and the potential of a biomarker can be quite difficult to evaluate. To aid in this imperative research, Dr. Kewal K. Jain’s Handbook of Biomarkers thoroughly describes many different types of biomarkers and their discovery using various "-omics" technologies, such as proteomics and metabolomics, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important emerging trends in healthcare today.

Автор: Weiner
Название: Translating Molecular Biomarkers into Clinical Assays
ISBN: 3319407929 ISBN-13(EAN): 9783319407920
Издательство: Springer
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Цена: 149060.00 T
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Описание: This handbook covers established and advanced techniques for biomarker analysis, such as guidelines and strategies for assay validation methods; different mathematical models that are necessary in contemporary drug discovery and development; and evaluation of new cytometry methods. Expertly curated by two practicing professionals in drug development and biotherapeutics, individual chapters are selected for novel and sound research; information is chosen based on its relevance to lab applications and clinical trials, such as the topic of selecting animal models for their relevancy to humans. The book is multifaceted, discussing the ethics and issues with biospecimens and providing an in-depth analysis to the differences between pre-clinical and clinical assay development. The book is an essential read for general readers who need an introduction to the history and background of biomarkers, and it also provides critical analyses of various new validation methods for practitioners and researchers.

Автор: Cho Kyung-Hyun
Название: High-Density Lipoproteins as Biomarkers and Therapeutic Tools: Volume 1. Impacts of Lifestyle, Diseases, and Environmental Stressors on Hdl
ISBN: 9811373892 ISBN-13(EAN): 9789811373893
Издательство: Springer
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Цена: 121110.00 T
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Описание: This book is the first of two volumes that offer a comprehensive, up-to-date account of current knowledge regarding high-density lipoprotein (HDL), the changes that occur in HDL under different conditions, the clinical applications of HDL, and means of enhancing HDL functionality.

Автор: Knudsen Lisbeth, Anderson Diana
Название: Biomarkers and Human Biomonitoring, Volume 2: Selected Biomarkers of Current Interest
ISBN: 1849732426 ISBN-13(EAN): 9781849732420
Издательство: Royal Society of Chemistry
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Цена: 175990.00 T
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Описание: This book provides an overview of current available biomarkers and human biomonitoring programs in environmental health, addressing current concerns regarding adverse health effects from environmental exposures.

Автор: ?akatay
Название: Redox Signaling and Biomarkers in Ageing
ISBN: 3030849678 ISBN-13(EAN): 9783030849672
Издательство: Springer
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Цена: 130430.00 T
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Описание: This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book. Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ? and tau proteins in Alzheimer's disease, ?-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers. Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients. This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike.

Автор: Vivek Kumar Gupta
Название: Biochemical Studies on Some Biomarkers of Xenobiotic Exposure
ISBN: 153619381X ISBN-13(EAN): 9781536193817
Издательство: Nova Science
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Цена: 149940.00 T
Наличие на складе: Невозможна поставка.
Описание: Pesticides belonging to carbamate and organophosphate groups have the potential to induce oxidative stress. However, the role of aqueous extract of A. vera has not been properly studied to demonstrate its ameliorative potential against the toxicity induced by these pesticides in single and combination in different organs of mammalian systems. After an extensive literature survey on the subject, an endeavour has been made to define the following objectives in order to fill up the existing lacuna of information about cartap and malathion induced oxidative stress in rat blood, brain and liver and its impact on neurotransmission as well as energy metabolism. Liver and blood were also included in this study for establishing a more meaningful agreement. The present study was therefore undertaken to delineate the differential impacts of cartap and malathion on the biochemical and histological parameters in Wistar rats. In addition, the prophylactic effect of aqueous extract of A. vera leaves has also been evaluated. The objectives of the present study include: evaluation of xenobiotic-induced oxidative stress, determination of activity of acetylcholinesterase and other esterases in the brains of rats exposed to xenobiotics as potential biomarkers of neurotoxicity; evaluation of different enzymes of energy metabolism in rats exposed to xenobiotics; measurement of specific parameters concerning the function of the kidney and liver in rats exposed to xenobiotics; evaluation of AChE isozyme profile to specifically understand the target of xenobiotics in the brain of rats; analysis of patterns of major biomolecules (proteins/DNA) in rats exposed to xenobiotics for different treatment durations; and assessment of the ameliorative impact of phytochemicals, if any, on xenobiotics. This book is divided into eight sections. Section 1 contains the general introduction and background of the study. Section 2 contains an extensive literature survey on the subject so as to present updated information. Section 3 demonstrates the main objectives of the study. Section 4 describes the various experimental designs, procedures, protocols, tools and techniques. Section 5 illustrates the data obtained from this study. Section 6 enumerates the discussion of the data and associated mechanisms. Section 7 includes the summary and conclusion of the entire study. Section 8 includes citations and references used in this work. This book contains many specific diagrams, illustrations and presentations in simple tables and figures which are self-explanatory so as to make any reader well versed to this subject. In addition, specific flow charts are added to simplify the presentation. We hope that this publication will be of great use to graduates, postgraduates, researchers and faculty members who are studying in the field of plant-based principles for alleviating pesticide toxicity and associated diseases. The tools and techniques explained in this title could be of immense use to all those working in this area. The authors welcome comments and suggestions to improve the quality of the content in the next edition.

Автор: Zhang, Lijuan
Название: Progress in Molecular Biology and Translational Science
ISBN: 0128177381 ISBN-13(EAN): 9780128177389
Издательство: Elsevier Science
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Цена: 133620.00 T
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Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part A, Volume 162 in the Progress in Molecular Biology and Translational Science series provides informative monographs on a variety of research topics related to Glycans and glycosaminoglycans as clinical biomarkers and therapeutics. Topics in this update include Glycan-based Biomarkers for Diagnosis of Cancers and Other Diseases: Past, Present and Future, Desialylation in Diseases and its Application in Diagnostic and Therapeutic Development, Proteoglycans as Miscommunication Biomarkers for Cancer Diagnosis, Fucosylation in Cancer Biology and Its Clinical Applications, Retrospective Analysis of Glycan-Related Biomarkers Based on Clinical Laboratory Data in Two Medical Centers, and many related topics.

Название: Biomarkers and Human Biomonitoring, Volume 1: Ongoing Programs and Exposures
ISBN: 1849732418 ISBN-13(EAN): 9781849732413
Издательство: Royal Society of Chemistry
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Цена: 227990.00 T
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Описание: This book provides an overview of current available biomarkers and human biomonitoring programs in environmental health, addressing current concerns regarding adverse health effects from environmental exposures.

Автор: de Jesus Jemmyson Romбrio
Название: Proteomic and Ionomic Study for Identification of Biomarkers in Biological Fluid Samples of Patients with Psychiatric Disorders and Healthy Individual
ISBN: 3030294757 ISBN-13(EAN): 9783030294755
Издательство: Springer
Цена: 93160.00 T
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Описание: This book presents an exploratory analysis based on proteomic and ionomics studies comparing the blood serum of patients with bipolar disorder (BD), healthy controls, patients with schizophrenia (SCZ), and patients with other disorders (OD) in order to identify biomarkers of BD.

Автор: Zhang, Lijuan
Название: Progress in Molecular Biology and Translational Science
ISBN: 0128177403 ISBN-13(EAN): 9780128177402
Издательство: Elsevier Science
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Цена: 133620.00 T
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Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part B, Volume 163 in the Progress in Molecular Biology and Translational Science series, provides informative monographs on a variety of research topics related to Glycans and glycosaminoglycans as clinical biomarkers and therapeutics. Topics in this update include an Overview of Fugal Glycan-based Therapeutics, Heparin: An Essential Drug for Modern Medicine, Low Molecular Weight Heparins and Their Clinical Applications, The Clinical Use of Fondaparinux: A Synthetic Heparin Pentasaccharid, Heparinoids as Clinically Used Drugs, Marine Glycan-Derived Therapeutics in China, Efficacy of Heparinoid PSS in Treating Cardiovascular and other Diseases--30 Years Clinical Applications in China, and more.

Автор: Hu, Qingyuan , Hou, Hongwei
Название: Tobacco Smoke Exposure Biomarkers
ISBN: 0367377764 ISBN-13(EAN): 9780367377762
Издательство: Taylor&Francis
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Цена: 65320.00 T
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Written by experts in the analytical chemistry of tobacco smoke, Tobacco Smoke Exposure Biomarkers summarizes the toxicology, metabolic pathway, and biomarkers of nicotine, TSNAs, PAHs, VOCs, AAs, Catechol and Hydroquinone, HCN, CO and NOx, and heavy metals, and the use of this biomarker in exposure assessment and/or cigarette smoke exposure environmental epidemiology.

A convenient one-stop guide, the book brings together information on some exposure biomarkers and nicotine addiction in humans with regulatory implications and strategies. The authors also include discussions of how smoke exposure biomarkers may be used to shape regulation and health policy. Ethics guidelines, details of method development, and the validated relative bioanalytical method provided in the appendixes rounds out the coverage. The book gives you tools to further research biomarkers for tobacco carcinogens and to face emerging health challenges such as delivery of nicotine via electronic cigarettes.

Название: Novel cancer-related biomarkers: Novel cancer-related biomarkers
ISBN: 3110481537 ISBN-13(EAN): 9783110481532
Издательство: Walter de Gruyter
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Цена: 24730.00 T
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Описание: Various KLK proteins and their encoding genes have attracted increased attention among scientists and clinicians worldwide since they represent very interesting and functionally distinct biomarkers, particularly, in cancer. This book reviews the role of kallikrein-related peptidases (KLKs) in a wide range of cancers, including lung, prostate, breast and ovarian cancer. It provides clinicians, physician scientists and researchers with a comprehensive overview on the clinical relevance of KLK expression in various malignancies.