Redox Signaling and Biomarkers in Ageing, ?akatay

Автор: Зakatay Ufuk
Название: Redox Signaling and Biomarkers in Ageing
ISBN: 3030849643 ISBN-13(EAN): 9783030849641
Издательство: Springer
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Цена: 130430.00 T
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Описание: This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach.

Название: Detection of Drug Misuse
ISBN: 1782621571 ISBN-13(EAN): 9781782621577
Издательство: Royal Society of Chemistry
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Цена: 122480.00 T
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Описание: This book describes recent advances in biomarkers, instrumentation and analysis methodology for identifying drug misuse. It is aimed at healthcare professionals, academics and postgraduates.

Автор: Alexey Moskalev
Название: Biomarkers of Human Aging
ISBN: 3030249697 ISBN-13(EAN): 9783030249694
Издательство: Springer
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Цена: 158380.00 T
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Описание: This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging.In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function).The book goes on to describe DNA methylation, known as the “epigenetic clock,” as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education. Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging.Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.

Автор: Moskalev Alexey
Название: Biomarkers of Human Aging
ISBN: 3030249727 ISBN-13(EAN): 9783030249724
Издательство: Springer
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Цена: 158380.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function). The book goes on to describe DNA methylation, known as the “epigenetic clock,” as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education. Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging. Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.

Автор: Armstrong Donald
Название: Oxidative Stress Biomarkers and Antioxidant Protocols
ISBN: 0896038505 ISBN-13(EAN): 9780896038509
Издательство: Springer
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Цена: 144410.00 T
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Описание: Donald Armstrong updates and expands his highly praised Free Radical and Antioxidant Protocols (Humana, 1998) with a collection of new and valuable methods for evaluating the pertubations in cell function resulting from increased oxidative stress. Presented in a user-friendly, step-by-step format, these readily reproducible techniques cover both free radical-derived and antioxidant biomarkers. The methodologies demonstrated include ELISA, HPLC, infrared spectroscopy, gas chromatography-mass spectroscopy, immunoblotting, electroelution fractionation, isoelectric focusing, voltametry, and electron paramagnetic resonance imaging. Special emphasis is given to the separation of complex mixtures of plant antioxidants, soft drug design to protect from toxic oxidative metabolites, in vitro oxidation conditions, and correcting for random measurement error to improve statistical interpretation. A soon-to-be-published companion volume, Oxidants and Antioxidants: Ultrastructural and Molecular Biology Protocols (0-89603-851-3), contains state-of-the-art molecular and ultrastructural methods that expand the total number of protocols to 109 assays.

Автор: Harndan
Название: Cancer Biomarkers. 2007
ISBN: 0471745162 ISBN-13(EAN): 9780471745167
Издательство: Wiley
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Цена: 142510.00 T
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Описание: Tools, techniques, and progress in cancer biomarkers discovery The completion of a number of gene sequencing projects, recent advances in genomic and proteomic technologies, and the availability of powerful bioinformatics tools have led to promising new avenues and approaches in the search for cancer biomarkers.

Автор: Lenz
Название: Biomarkers in Oncology
ISBN: 1461483158 ISBN-13(EAN): 9781461483151
Издательство: Springer
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Цена: 111790.00 T
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Описание: This integrated book covers the entire spectrum of cancer biomarkers in development and clinical use. Predictive and prognostic markers are explored in the context of colon cancer, breast cancer, lung cancer, prostate cancer, and GIST.

Автор: Karsdal, Morten
Название: Biochemistry of Collagens, Laminins and Elastin
ISBN: 0128098473 ISBN-13(EAN): 9780128098479
Издательство: Elsevier Science
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Цена: 99930.00 T
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Описание: Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. . This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease.

Название: Novel cancer-related biomarkers: Novel cancer-related biomarkers
ISBN: 3110481537 ISBN-13(EAN): 9783110481532
Издательство: Walter de Gruyter
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Цена: 24730.00 T
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Описание: Various KLK proteins and their encoding genes have attracted increased attention among scientists and clinicians worldwide since they represent very interesting and functionally distinct biomarkers, particularly, in cancer. This book reviews the role of kallikrein-related peptidases (KLKs) in a wide range of cancers, including lung, prostate, breast and ovarian cancer. It provides clinicians, physician scientists and researchers with a comprehensive overview on the clinical relevance of KLK expression in various malignancies.

Автор: Agarwal
Название: Proteomics in Human Reproduction
ISBN: 3319484168 ISBN-13(EAN): 9783319484167
Издательство: Springer
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Цена: 51230.00 T
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Описание: This Brief explores the use of proteomics as a tool for biomarker discovery in human reproduction and summarizes current findings and trends of proteomic studies in both male and female infertility. This simplifies this important but complex topic and equips the novice reader with sufficient background information on the use of proteomics in human reproduction. The up-to-date scenario on proteomic investigations will also appeal to researchers and post graduate students looking to keep abreast with the latest developments in reproductive research. This review summarizes current findings of contemporary proteomic studies on infertility in both males and females with various reproductive pathologies, and its use in predicting the outcome of assisted reproduction. In human reproduction, the search for biomarkers via proteomics is a fast-evolving approach that involves the analysis of proteins in the reproductive tissues and fluids, such as the male gametes, seminal plasma, ovarian and endometrial tissue, and follicular and uterine fluid. By comparing the protein profile of a healthy, fertile individual against that of an infertile individual, the differentially expressed proteins may give an indication to certain proteins that could serve as useful biomarkers that are related to infertility. As proteomic studies continue to unravel the dynamic proteome behind various infertility conditions, there is potential for the discovery of prognostic markers that could ultimately help in both natural and assisted human reproduction.

Название: Technical aspects of toxicological immunohistochemistry
ISBN: 1493915150 ISBN-13(EAN): 9781493915156
Издательство: Springer
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Цена: 139750.00 T
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Описание: This authoritative volume examines immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues.

Автор: Manuel Men?ndez Gonz?lez
Название: Atlas of Biomarkers for Alzheimer`s Disease
ISBN: 3319079883 ISBN-13(EAN): 9783319079882
Издательство: Springer
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Цена: 93160.00 T
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Описание: A lot of research on biomarkers for Alzheimer is being done in the last few decades. The aim of these studies is to find some method to ease the diagnosis of Alzheimers as early as possible. Such methods are a range of blood or CSF tests on one hand and several types of neuroimaging scans on the other. Many of the images coming both from laboratory and neuroimaging are very visual and illustrative. These images, accompanied by a short description, can perfectly explain the main results and usefulness of every biomarker. The objective of this book would be to summarize the most important studies made in this field. Few publications have systematically compiled results on this topic and only one as an atlas. Readers would be interested in this publication because it allows reviewing the current status of research by handily visualizing the results.