Signaling Mechanisms Regulating T Cell Diversity and Function, Soboloff, Jonathan
Автор: Ralph A. Bradshaw Название: Regulation of Organelle and Cell Compartment Signaling, ISBN: 0123822130 ISBN-13(EAN): 9780123822130 Издательство: Elsevier Science Рейтинг: Цена: 65110.00 T Наличие на складе: Нет в наличии. Описание: Suitable for researchers across molecular biology, biochemistry, cell biology and genetics, this title includes articles that emphasize signaling to and from intracellular compartments including transcriptional responses to cytoplasmic and nuclear signaling events, chromatin remodeling and stress responses, and more.
Автор: E. Bermek Название: Mechanisms of Protein Synthesis ISBN: 3642699146 ISBN-13(EAN): 9783642699146 Издательство: Springer Рейтинг: Цена: 139310.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the Symposium on Molecular Mechanisms in Protein Synthesis, held at Beyaz Kosc, Emirgan, Bosporus, Istanbul
Автор: Rosenhouse-Dantsker Avia, Bukiya Anna N. Название: Direct Mechanisms in Cholesterol Modulation of Protein Function ISBN: 3030142647 ISBN-13(EAN): 9783030142643 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis. Direct Mechanisms in Cholesterol Modulation of Protein Function offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are organized into two distinct parts. In the first part, the chapters introduce the reader to the general characteristics of cholesterol binding sites in proteins. This part starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmembrane and soluble protein domains. In the second part of the book, examples of cholesterol binding sites and consequences of specific cholesterol recognition for protein function are presented for G protein-coupled receptors, ion channels and cholesterol-transporting proteins. The book is valuable for undergraduate and graduate students in biochemistry and nutrition, as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
Автор: Avia Rosenhouse-Dantsker; Anna N. Bukiya Название: Cholesterol Modulation of Protein Function ISBN: 3030042774 ISBN-13(EAN): 9783030042776 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In this book, renowned scientists describe the role of steroid chirality and modification of lipid membrane physical properties in the modulation of G protein-coupled receptors and ion channels. The application of commonly-used technical approaches such as mass spectrometry and nucleic magnetic resonance transfer spectroscopy for studies on cholesterol distribution and alteration of lipid bilayer characteristics is also discussed. This book offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via mechanisms that extend beyond lipid-protein direct interactions. In the first part, the chapters introduce the reader to the use of the chemical derivatives of cholesterol as a valuable laboratory tool in the studies of cholesterol-driven modulation of protein function. In the second part, examples of cholesterol-induced changes in membrane physical characteristics are presented and discussed in light of their multifaceted contribution to the effect of cholesterol on protein function. The book will be of interest to undergraduate and graduate students as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.
Автор: Richardson Guy P., Petit Christine Название: Function and Dysfunction of the Cochlea: From Mechanisms to Potential Therapies ISBN: 1621822796 ISBN-13(EAN): 9781621822790 Издательство: Неизвестно Рейтинг: Цена: 49140.00 T Наличие на складе: Нет в наличии. Описание: The cochlea is a spiral-shaped structure in the inner ear that is responsible for hearing. It converts sound vibrations into electrical signals and sends them to the brain with remarkable precision. Defects in the cellular or molecular components of the cochlea can lead to deafness and other hearing impairments. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the complex molecular machinery that is responsible for cochlear function and describes recent advances in understanding and treating various forms of hearing loss. The contributors focus on the highly specialized cells that are critical for auditory transduction--the hair cells--and their unique molecular and biomechanical characteristics. They also consider the properties of other cochlear components, including the tectorial membrane, synaptic connections, and resident macrophages, as well as the development and evolution of the cochlea as a whole. Topics such as hair cell regeneration, otoacoustic emissions, and ototoxicity are also discussed. In addition, the authors examine the epidemiology and pathology of hearing loss and emerging therapeutic strategies (e.g., optical cochlear implants) for addressing it. This volume is therefore a valuable reference for cell biologists and neuroscientists interested in the biology of hearing, as well as physicianDSscientists seeking new approaches to alleviate hearing impairments.
Название: Apoptosis, Cell Signaling & Human Diseases. Vol1. 2007 ISBN: 1588296776 ISBN-13(EAN): 9781588296771 Издательство: Springer Рейтинг: Цена: 191560.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Aims to provide developments in cell survival and apoptotic pathways and their involvement in various human diseases. This book contains 31 chapters which have been divided into four sections: Malignant Transformation and Metastasis; Kinases and Phosphatases; Molecular Basis of Cell Death; and Molecular Basis of Disease Therapy.
Автор: Alfred Wittinghofer Название: Ras Superfamily Small G Proteins: Biology and Mechanisms 1 ISBN: 3709118050 ISBN-13(EAN): 9783709118054 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.
Автор: Rakesh Srivastava Название: Apoptosis, Cell Signaling, and Human Diseases ISBN: 1617377139 ISBN-13(EAN): 9781617377136 Издательство: Springer Рейтинг: Цена: 148010.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: These volumes present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways.
Автор: Rakesh Srivastava Название: Apoptosis, Cell Signaling, and Human Diseases ISBN: 1617378232 ISBN-13(EAN): 9781617378232 Издательство: Springer Рейтинг: Цена: 174130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 and 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer.
This invaluable book provides the first description of the diverse and fascinating functions of heme in life processes for a broad audience. It begins with an introduction of the intricate chemical properties of heme and the history of early observations of human diseases associated with heme. It then proceeds to describe the versatile roles of heme in controlling diverse molecular and cellular processes germane to human life and disease processes. In the second edition, a new chapter is devoted to describe findings about heme uptake, transport, and trafficking of heme synthesis intermediates in mammals. Additionally, a chapter about the newly discovered roles of elevated heme biosynthesis and uptake in lung tumorigenesis is included.
Heme Biology is unified and logical in presentation. It is well suited for students and professionals in life sciences who wish to know about the fascinating biology of heme and its usefulness in health and diseases. It may also be used as a reference book for advanced readers and researchers who are interested in heme biology. The explanations in the book are detailed enough to capture the interest of the curious reader, and complete enough to provide the necessary information for researchers to have an in-depth molecular understanding of heme biology and further their studies in this fascinating realm.
Автор: Bradshaw, Ralph A. Название: Functioning Of Transmembrane Receptors In Signaling Mechanisms ISBN: 0123822114 ISBN-13(EAN): 9780123822116 Издательство: Elsevier Science Рейтинг: Цена: 65110.00 T Наличие на складе: Нет в наличии. Описание: A primary component of cell signaling research, this title covers the principal membrane-bound receptor families, including their structural organization. It provides research on transmembrane signaling entities and their initiating responses following extracellular stimulation.
Автор: Dennis, Edward A. Название: Transduction Mechanisms In Cellular Signaling ISBN: 0123838622 ISBN-13(EAN): 9780123838629 Издательство: Elsevier Science Рейтинг: Цена: 65110.00 T Наличие на складе: Нет в наличии. Описание: Cytosol, the liquid found inside cells, is the site for multiple cell processes, including signaling from the cell membrane to sites within the cell. This title includes articles and features research on signaling systems and mutations in transcription factors that provide targets for treating disease.
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