Mitochondrial Medicine, Green, George Dawes

Автор: Weissig Volkmar, Edeas Marvin
Название: Mitochondrial Medicine: Volume 1: Targeting Mitochondria
ISBN: 1071612611 ISBN-13(EAN): 9781071612613
Издательство: Springer
Цена: 144410.00 T
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Описание: This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.

Название: Mitochondrial disorders caused by nuclear genes
ISBN: 1489992413 ISBN-13(EAN): 9781489992413
Издательство: Springer
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Цена: 174130.00 T
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Описание: This book surveys mutations in the inherited maternal mitochondrial genome, or the nuclear DNA-mutation, covering the biochemical, molecular, clinical, and genetic aspects of syndromes and heterogeneous mitochondrial disease caused by specific genes.

Автор: Navas
Название: Mitochondrial Diseases
ISBN: 3030701492 ISBN-13(EAN): 9783030701499
Издательство: Springer
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Цена: 130430.00 T
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Описание: Mitochondrial diseases comprise a clinically and genetically heterogeneous group of rare disorders that may affect virtually any system of the body at any age. Due to their complexity, understanding and diagnosing these diseases requires a multidisciplinary approach. This book provides an update on the major features of human mitochondrial diseases: genetic bases, pathophysiology, diagnosis, and treatment, and of the new technologies involved in the diagnosis and on the characterization of patients. The 11 chapters examine the unique complex interactions between the mitochondrial and the nuclear genomes involved in the biogenesis and the regulation of the mitochondrial respiratory chain, and their relevance to human disease. We discuss the traditional biochemical and genetic approaches, as well as the new omic technologies, and the cellular and animal models used in mitochondrial research. The last chapter is dedicated to the current treatment options. Authors are worldwide experts in these fields and integrate expertise in both basic science and clinical research. This book is particularly important for both scientists and clinicians interested in the diagnosis and treatment of these diseases.

Автор: Navas Placido, Salviati Leonardo
Название: Mitochondrial Diseases: Theory, Diagnosis and Therapy
ISBN: 3030701468 ISBN-13(EAN): 9783030701468
Издательство: Springer
Цена: 130430.00 T
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Описание:
PrefaceChapter 1 Two genomes connection: biogenesis of mitochondria respiratory chain
Chapter 2 Nuclear DNA: mutations in structural subunits and assembly factorsChapter 3 Defects of mtDNAChapter 4 MtDNA maintenance genes and depletionChapter 5 Defects in mitochondrial protein synthesisChapter 6 Defects in mitochondria dynamicsChapter 7 CoQ biosynthesis disordersChapter 8 Cytochrome c mutationsChapter 9 Biochemical approaches for mitochondrial diseases diagnosisChapter 10 Molecular genetics in the Next Generation Sequencing era Chapter 11 Model cells and organismsChapter 12 Metabolomics and proteomics: complementary toolsChapter 13 Therapies approaches in mitochondrial diseasesIndex

Автор: Weissig Volkmar, Edeas Marvin
Название: Mitochondrial Medicine: Volume 2: Assessing Mitochondria
ISBN: 1071612654 ISBN-13(EAN): 9781071612651
Издательство: Springer
Цена: 111790.00 T
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Описание:

1. Mitochondrial Dysfunction in Mitochondrial Medicine: Current Limitations, Pitfalls, and Tomorrow

Shima Mehrvar, Amadou K. S. Cama

Автор: Viswanathan Natarajan; Narasimham L. Parinandi
Название: Mitochondrial Function in Lung Health and Disease
ISBN: 1493944363 ISBN-13(EAN): 9781493944361
Издательство: Springer
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Цена: 111790.00 T
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Описание: Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling.

Автор: Weissig Volkmar, Edeas Marvin
Название: Mitochondrial Medicine: Volume 3: Manipulating Mitochondria and Disease- Specific Approaches
ISBN: 1071612697 ISBN-13(EAN): 9781071612699
Издательство: Springer
Цена: 111790.00 T
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Описание: This volume in the Encyclopedia of Sustainability Science and Technology, Second Edition, describes the breadth of science and engineering knowledge critical to advancing sustainable built environments, from architecture and design, mechanical engineering, lighting, and materials to water and energy, public policy, and economics.

Автор: Justin C. St. John
Название: Mitochondrial DNA, Mitochondria, Disease and Stem Cells
ISBN: 1627038671 ISBN-13(EAN): 9781627038676
Издательство: Springer
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Цена: 148010.00 T
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Описание: The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process.

Автор: Natarajan
Название: Mitochondrial Function in Lung Health and Disease
ISBN: 1493908286 ISBN-13(EAN): 9781493908288
Издательство: Springer
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Цена: 139750.00 T
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Описание: Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling.

Автор: Falk, Marni J.
Название: Mitochondrial Disease Genes Compendium
ISBN: 0128200294 ISBN-13(EAN): 9780128200292
Издательство: Elsevier Science
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Цена: 144850.00 T
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Описание:

The field of Mitochondrial Medicine has been dominated by symptom constellation-based diagnostic categorization since the first clinical syndrome was described three decades ago. Now, as rapidly expanding knowledge has revealed that mitochondrial diseases may result from several hundred distinct gene disorders with extensive clinical and mutation heterogeneity, the most useful guide for clinical care and research embraces a gene-centric approach to each individual's disorder. Together with international colleagues, Dr. Marni Falk has developed the Mitochondrial Disease Sequence Data Resource (MSeqDR), an online, community curated, centralized data resource of mitochondrial disease data from a genomic perspective. MSeqDR provides tens of thousands of users with interactive access to mitochondrial disease feature descriptions in a defined human phenotype ontology, mitochondrial proteome-based gene and variant curation, and a suite of easily accessible tools to facilitate analysis of complex genomic datasets in nuclear and mitochondrial genomes as well as accurate interpretation of mitochondrial disease genes, variants, and diseases.

Автор: House, Patrick
Название: Mitochondrial Medicine
ISBN: 1071612727 ISBN-13(EAN): 9781071612729
Издательство: Springer
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Цена: 111790.00 T
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Описание: The chapters are categorized into seven major groups according to the reporter materials, such as imaging with passive optical readouts, activatable bioluminescent probes, functional substrates and luciferases, organic fluorescent probes, BRET probes, FRET probes, as well as with advanced instrumentation.

Автор: Patrick Lestienne
Название: Mitochondrial Diseases
ISBN: 3642641660 ISBN-13(EAN): 9783642641664
Издательство: Springer
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Цена: 104480.00 T
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Описание: For those like me who witnessed the beginning of the adventure of human mitochon- drial pathology, one can only be astounded by the extent and unexpectedness of what the field has come to offer. Extent because nobody could have imagined the sheer size of the domain. Unexpectedness because hitherto it was impossible to imagine the clinical polymorphism that this pathology would represent. The starting point was clear. Initially, there was the exceptional, and for a long time unique, observation of euthyroidian hypermetabolism that Luft and colleagues analyzed remarkably in biochemical and clinical terms. Thereafter, there was the support provided by the electron microscopy studies of Afzelius, and the very first visualization of mitochondrial abnormalities. That was way back in 1958. A few years later, progress in the cytology and cytochemistry of skeletal muscle tissue was to provide the means of detecting such abnormalities by examining sections with light microscopy. The colorful term "ragged red fibers", coined by W. K. Engel, became uni- versally accepted, and this typical aspect with Gomori trichrome stain was to throw light on the frequency with which these mitochondrial abnormalities could occur under pathological conditions which, until then, had remained a total mystery regard- ing their mechanism: syndromes such as the ocular myopathies with their descending evolution and the oculocraniosomatic syndromes. We were at the beginning of the 1970s.