Mitochondrial Diseases: Theory, Diagnosis and Therapy, Navas Placido, Salviati Leonardo
Автор: Orrenius Название: Mitochondrial Signaling in Health and Disease ISBN: 1439880026 ISBN-13(EAN): 9781439880029 Издательство: Taylor&Francis Рейтинг: Цена: 193950.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.
With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:
Electron transport and energy production
Mitochondrial biogenesis and dynamics
Mitochondrial signaling
Apoptosis and autophagy
Pharmacology signaling
Epigenetic signaling: mitochondrial methylation and acetylation reactions
An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
The book begins with my own health journey through mitochondrial fatigue and how I overcame it with the functional medicine approach to diagnosis and treatment. The first two chapters discuss the basic science of the mitochondria and their involvement in cell defense, energy production, aging, and cancer. The following chapters deals with the avoidance of chemicals, pesticides, and toxins that poison the mitochondria, food to nourish them, supplements, and hormetic lifestyle changes. The next chapter details the functional medicine approach to patient's symptoms using lab testing to arrive at the diagnosis and treatment. The book concludes with a summary of actionable items that the reader can do at home.
If you suffer from chronic fatigue, excess fat that you can't lose, brain fog, or any number of symptoms, the answer might just lie deep in your cell called mitochondria. They are responsible to make energy called ATP for the cell to function. If they sense danger to the cell and to themselves, they will shut down ATP production and go into cell defense mode, resulting in generalized dysfunction of the most active cells like the muscles and brain. You can now reverse this process using a validated method by the Mayo Clinic.
Dr. Chang has personally gone through a health journey of mitochondrial dysfunction and fatigue and by applying the methods in the book, he has fully recovered.
Автор: Mancuso Название: Diagnosis and Management of Mitochondrial Disorders ISBN: 3030055167 ISBN-13(EAN): 9783030055165 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Невозможна поставка. Описание: This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest.
Автор: Iain P. Hargreaves Название: Mitochondrial Respiratory Chain Disorders: From Clinical Presentation to Diagnosis and Treatment ISBN: 1536150533 ISBN-13(EAN): 9781536150537 Издательство: Nova Science Рейтинг: Цена: 84470.00 T Наличие на складе: Невозможна поставка. Описание: Mitochondrial respiratory (MRC) disorders are a phenotypically and genetically diverse group of diseases which have an estimated incidence of 1 in 5000, and can manifest at any age with virtually any symptom. These disorders are generally progressive and multi-systemic, typically affecting organs with high energy demands, although potentially any organ can be affected. In view of their wide spectrum of clinical symptoms, together with their complex genetics, the diagnosis of these disorders presents a real challenge and usually requires a multidisciplinary approach involving clinical, genetic, histological, and biochemical investigations. In addition, an MRC defect may also occur as a secondary consequence of disease pathophysiology, as well as drug toxicity, further complicating the diagnostic algorithm for these disorders. The accurate diagnosis of MRC disorders is also hindered by the lack of reliable and validated biomarkers or surrogates for evaluating evidence of MRC dysfunction. Treatment options for MRC disorders are quite limited with no actual cure as yet in sight. Currently, apart from supportive therapies to manage the various clinical presentations of these diseases, patients can receive a host of antioxidants, vitamins, and cofactors in an attempt to maximize residual MRC function, and to combat the oxidative stress associated with these diseases. However, at present there appears to be a distinct lack of consensus on the appropriate treatment regime to instigate in patients with these disorders. Although, it is hoped that the establishment of national and international cohorts of patients with MRC disorders will allow the development of a unified approach to the development of candidate strategies for the treatment of these patients. In recent years, pharmacotherapies aimed at enhancing mitochondrial biogenesis have received a lot of attention, with some of them now being used in phase II clinical trials to assess evidence of their therapeutic efficacy in patients. The purpose of this book is to outline the clinical presentation and the genetic and non-genetic causes of MRC disorders, as well as highlighting evidence of secondary mitochondrial dysfunction in disease. In addition, the current biochemical methods used in the diagnosis of MRC dysfunction will be discussed together with the potential future developments in this field. The current treatment options available to patients with MRC disorders will also be discussed together with novel, biochemical, therapeutic strategies which have yet to reach clinical application.
Автор: F.N. Gellerich; S. Zierz Название: Detection of Mitochondrial Diseases ISBN: 1461378001 ISBN-13(EAN): 9781461378006 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Patrick Lestienne Название: Mitochondrial Diseases ISBN: 3642641660 ISBN-13(EAN): 9783642641664 Издательство: Springer Рейтинг: Цена: 104480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: For those like me who witnessed the beginning of the adventure of human mitochon- drial pathology, one can only be astounded by the extent and unexpectedness of what the field has come to offer. Extent because nobody could have imagined the sheer size of the domain. Unexpectedness because hitherto it was impossible to imagine the clinical polymorphism that this pathology would represent. The starting point was clear. Initially, there was the exceptional, and for a long time unique, observation of euthyroidian hypermetabolism that Luft and colleagues analyzed remarkably in biochemical and clinical terms. Thereafter, there was the support provided by the electron microscopy studies of Afzelius, and the very first visualization of mitochondrial abnormalities. That was way back in 1958. A few years later, progress in the cytology and cytochemistry of skeletal muscle tissue was to provide the means of detecting such abnormalities by examining sections with light microscopy. The colorful term "ragged red fibers", coined by W. K. Engel, became uni- versally accepted, and this typical aspect with Gomori trichrome stain was to throw light on the frequency with which these mitochondrial abnormalities could occur under pathological conditions which, until then, had remained a total mystery regard- ing their mechanism: syndromes such as the ocular myopathies with their descending evolution and the oculocraniosomatic syndromes. We were at the beginning of the 1970s.
Название: Mitochondrial Dysfunction in Aging and Diseases of Aging ISBN: 303921327X ISBN-13(EAN): 9783039213276 Издательство: Неизвестно Рейтинг: Цена: 71110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.
Автор: Nixon Ronan Название: Understanding Mitochondrial Diseases ISBN: 1632429039 ISBN-13(EAN): 9781632429032 Издательство: Неизвестно Рейтинг: Цена: 156640.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Mitochondrial diseases refer to a group of disorders that are caused due to dysfunctional mitochondria. They may arise due to mutations in the mitochondrial DNA or in nuclear genes which code for mitochondrial components. Some of the conditions for which there exists evidence for the association of mitochondrial dysfunction are Huntington's disease, Alzheimer's disease, bipolar disorder, Parkinson's disease, schizophrenia, etc. When defective mitochondria occur in the muscles, nerves or cerebrum, they lead to debilitating conditions. The symptoms of mitochondrial disease are loss of muscle coordination, poor growth, muscle weakness, hearing and learning disabilities, visual difficulties, liver disease, heart disease, kidney disease, gastrointestinal disorders, etc. The most common diagnostic tests for the detection of mitochondrial diseases are PCR and specific mutation analysis, southern blot and sequencing. Spindle therapy, embryonic mitochondrial transplant and protofection are potential treatments for inherited mitochondrial diseases. This book includes some of the vital pieces of work being conducted across the world, on various topics related to mitochondrial diseases. It consists of contributions made by international experts. With state-of-the-art inputs by acclaimed experts of medical genetics, this book targets students and professionals.
Автор: Hongzhi Sun; Xiangdong Wang Название: Mitochondrial DNA and Diseases ISBN: 9811349290 ISBN-13(EAN): 9789811349294 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Нет в наличии. Описание: The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing. Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA–associated diseases.
Автор: Michael Forte; Marco Colombini Название: Molecular Biology of Mitochondrial Transport Systems ISBN: 3642789382 ISBN-13(EAN): 9783642789380 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the NATO Advanced Research Workshop on Molecular Biology of Mitochondrial Transport Systems, held at Il Ciocco, Italy, September 17 - 21, 1992
Автор: Paul R. Sanberg; Hitoo Nishino; Cesario V. Borlong Название: Mitochondrial Inhibitors and Neurodegenerative Disorders ISBN: 089603805X ISBN-13(EAN): 9780896038059 Издательство: Springer Рейтинг: Цена: 231990.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function.
Автор: Angelo Azzi; Katarzyna A. Nalecz; Maciej J. Nalecz Название: Anion Carriers of Mitochondrial Membranes ISBN: 3642745415 ISBN-13(EAN): 9783642745416 Издательство: Springer Рейтинг: Цена: 102480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: All relevant structural and functional aspects of the Anion Carriers of Mitochondrial Membranes as well as isolation procedures, reconstitution experiments and biogenesis of the carriers, kinetics of transport as well as the metabolic regulation mechanisms are treated in this volume.
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