Immune Receptors, Sivaramakrishnan, S. Razia, M.

Автор: Abbas, Abul K.
Название: Basic Immunology, 6 Ed
ISBN: 0323549438 ISBN-13(EAN): 9780323549431
Издательство: Elsevier Science
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Цена: 58940.00 T
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Описание: Meticulously reviewed and updated for today's medical students, Basic Immunology, 6th Edition, is a concise text expertly written by the same distinguished author team as the best-selling, comprehensive text, Cellular and Molecular Immunology. This focused, easy-to-understand volume uses full-color illustrations and clinical images, useful tables, and practical features such as Summary Point boxes, end-of-chapter review questions, glossary terms, and clinical cases-all designed to help students master this complex topic in the most efficient, effective manner possible. Emphasizes clinical aspects of immunology, including disease pathogenesis, the development of novel therapies based on basic science, and an appendix of clinical cases for real-world application.

Provides top-notch instruction from experienced teachers, course directors, and lecturers led by well-known editor and author Dr. Abul Abbas. Features a highly readable writing style and practical organization, now with fully revised content and updated images to reflect recent important advances in today's understanding of the immune system.

Provides additional online features such as answers to in-book chapter review questions, helpful animations, and up to 10 self-assessment questions per chapter. Presents information in a format and style that maximizes usefulness to students and teachers studying medicine, allied health fields, and biology. Contains numerous features designed to help students understand key immunologic concepts: high-quality illustrations, practical tables, chapter outlines, bolded key points, and focus questions in every chapter for self-assessment and review.

Includes an Enhanced eBook version with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Автор: Jonathan P. Rast; James W.D. Booth
Название: Immune Receptors
ISBN: 1493957988 ISBN-13(EAN): 9781493957989
Издательство: Springer
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Цена: 135090.00 T
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Описание: This book presents technical descriptions and protocols for a variety of experimental approaches to the characterization of immune receptors and the cell biology that mediates their functions. Written in the successful Methods in Molecular Biology (TM) format.

Автор: Shukla, Arun K.
Название: G Protein-Coupled Receptors in Immune Response and Regulation
ISBN: 0128124032 ISBN-13(EAN): 9780128124031
Издательство: Elsevier Science
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Цена: 151590.00 T
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Описание: G Protein-Coupled Receptors in Immune Response and Regulation, Volume 136 presents emerging concepts related to the role of GPCRs in immune response and regulation. Users will find updated chapters on a variety of topics, including Beta-adrenergic signaling in the onset and progression of asthma, the Emerging roles of Regulators of G protein signaling (RGS) proteins in the immune system, information on Kinin receptors in immune response and pathogenic infections, and sections on GPCR signaling in C. elegans and its implications in immune response, GPCR Kinases in Inflammatory response and signaling, and GRK2 in Inflammation: Regulation of T cell receptors and IgE signaling. . Chapters in this book discuss not only the well-known aspects of GPCR signaling in immunology, but also presents many emerging paradigms that have not yet been reported in classical textbooks. Each chapter presents a forward-looking discussion, providing a glimpse of the tremendous potential associated with the specific receptor systems discussed.

Автор: Rast
Название: Immune Receptors
ISBN: 1617791385 ISBN-13(EAN): 9781617791383
Издательство: Springer
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Цена: 135090.00 T
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Описание: Immunology has made significant progress in the past decade, driven forward by rapidly advancing technology and a renewed interest in the vast realm of innate immunity. The receptors that mediate these functions are at the front lines of both protective and regulative roles of the immune system.  In Immune Receptors: Methods and Protocols, expert researchers present a variety of experimental approaches to the characterization of immune receptors and the cell biology that mediates their functions.  These include imaging techniques that aim to understand receptor localization and trafficking, techniques to measure receptor-ligand interactions, strategies to identify novel ligands and methods to analyze downstream receptor signaling, as well as strategies for genomic and proteomic characterization of receptor repertoires. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immune Receptors: Methods and Protocols offers technical descriptions and protocols that will be useful both to investigators who are interested in carrying out these procedures and to those who seek a deeper understanding of the bench science that lies behind the immunology literature.

Автор: Tak W. Mak
Название: Primer to The Immune Response,
ISBN: 0123852455 ISBN-13(EAN): 9780123852458
Издательство: Elsevier Science
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Цена: 88690.00 T
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Описание: Suitable for college and university students in life sciences, medicine and other health professions who need an introduction to immunology, this book offers a survey of the fundamental concepts in basic and clinical immunology while conveying the subject`s appeal.

Автор: Reid Eric
Название: Investigation of Membrane-Located Receptors
ISBN: 1468446339 ISBN-13(EAN): 9781468446333
Издательство: Springer
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Цена: 113190.00 T
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Описание: But `Proceedings` are proverbially ephemeral material reflecting an array of solo performances, whereas this book is hopefully more like an orchestra`s performance, of classical together with new material. Related to receptor methodo- logy, receptor features and phenomena get due attention in the text.

Автор: Tammy Kielian
Название: Toll-like Receptors: Roles in Infection and Neuropathology
ISBN: 3642269117 ISBN-13(EAN): 9783642269110
Издательство: Springer
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Цена: 186330.00 T
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Описание: This book highlights traditional roles for TLRs in infectious diseases of the CNS. It also discusses recently emerging roles for TLRs in non-infectious neurodegenerative diseases and the challenges faced in these models with identifying endogenous ligands.

Автор: Fridman
Название: Discoidin Domain Receptors in Health and Disease
ISBN: 1493963813 ISBN-13(EAN): 9781493963812
Издательство: Springer
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Цена: 156720.00 T
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Описание: The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.

Автор: Anton G. Kutikhin; Arseniy E. Yuzhalin
Название: Genomics of Pattern Recognition Receptors
ISBN: 3034806876 ISBN-13(EAN): 9783034806879
Издательство: Springer
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Цена: 139310.00 T
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Описание: This book details the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, coverage examines the structure and function of Toll-like and NOD-like receptors.

Автор: Marc Daeron; Falk Nimmerjahn
Название: Fc Receptors
ISBN: 3319379097 ISBN-13(EAN): 9783319379098
Издательство: Springer
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Цена: 130590.00 T
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Описание: Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection.

Автор: Anthony D. Whetton; John Gordon
Название: Blood Cell Biochemistry
ISBN: 1475770529 ISBN-13(EAN): 9781475770520
Издательство: Springer
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Цена: 186330.00 T
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Описание: Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin.

Автор: Kubagawa Hiromi, Burrows Peter D.
Название: Igm and Its Receptors and Binding Proteins
ISBN: 3319878107 ISBN-13(EAN): 9783319878102
Издательство: Springer
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Цена: 130430.00 T
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Описание: This volume reviews the current state of research on the IgM antibody and its multiple receptors and binding proteins. The book includes up-to-date information on: (i) the phylogeny of three IgM-binding receptors [polymeric Ig receptor (pIgR), Fc receptor for both IgA and IgM (Fc /R), and Fc receptor for IgM only (FcR)];