Histone Deacetylase Inhibitors As Cancer Therapeutics,116, Grant, Steven

Автор: Vipin Chandra Kalia
Название: Biotechnological Applications of Quorum Sensing Inhibitors
ISBN: 9811343020 ISBN-13(EAN): 9789811343025
Издательство: Springer
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Цена: 139750.00 T
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Описание: This book discusses the practical applications of quorum sensing inhibitors for both human and plant health. Quorum sensing inhibitors that disrupt microbial biofilms can be employed to treat bacterial infections. The book describes the various bioactive molecules that can serve as quorum sensing inhibitors to combat deadly bacterial infections, in addition to several synthetic quorum sensing inhibitors.Quorum sensing is the mechanism through which bacteria develop antibiotic resistance. Intended to provide a clearer understanding of the practical applications of quorum sensing inhibitors, the book details how the problem of antibiotic resistance can be countered through the intelligent application of quorum sensing inhibitors.

Автор: Shabir Ahmad Ganai
Название: Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders
ISBN: 981138021X ISBN-13(EAN): 9789811380211
Издательство: Springer
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Цена: 93160.00 T
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Описание: It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders.

Автор: Kalia
Название: Biotechnological Applications of Quorum Sensing Inhibitors
ISBN: 9811090254 ISBN-13(EAN): 9789811090257
Издательство: Springer
Рейтинг:
Цена: 139750.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book describes the various bioactive molecules that can serve as quorum sensing inhibitors to combat deadly bacterial infections, in addition to several synthetic quorum sensing inhibitors.Quorum sensing is the mechanism through which bacteria develop antibiotic resistance.

Название: Viral proteases and their inhibitors
ISBN: 0128097124 ISBN-13(EAN): 9780128097120
Издательство: Elsevier Science
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Цена: 105540.00 T
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Описание: Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.

Автор: Margueron
Название: Histone Methyltransferases
ISBN: 1071624806 ISBN-13(EAN): 9781071624807
Издательство: Springer
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Цена: 144410.00 T
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Описание: This volume provides methods used to investigate histone methyltransferase function. Chapters guide readers through a comprehensive set of approaches that detail phylogenetic diversity, histone demethylase activities in vitro, generating chromatin substrates, auto-methylation, quantification of metabolites, protein purification, crystallization, X-ray structure, cryogenic electron microscopy, assessing genome-wide patterns, CUT&Tag in mouse embryonic tissues, chemical biology approaches, peptide SPOT arrays, nascent chromatin capture, ectopic protein tethering, computational models, and development of methyltransferase inhibitors. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Histone Methyltransferases: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.

Автор: Fred E. Hahn
Название: Modes and Mechanisms of Microbial Growth Inhibitors
ISBN: 3642689485 ISBN-13(EAN): 9783642689482
Издательство: Springer
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Цена: 121110.00 T
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Описание: Further search for antibiotics has led to increasing frequency of rediscoveries and drasti- cally decreasing frequency of discoveries of new antibiotics.

Автор: Shabir Ahmad Ganai
Название: Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders
ISBN: 981138018X ISBN-13(EAN): 9789811380181
Издательство: Springer
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Цена: 130430.00 T
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Описание: This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders. The book explores the potential use of these inhibitors as novel therapeutic agents, considers the current challenges involved in using them to tackle neurological complications, and offers a novel solution by designing isoform-selective inhibitors and employing combinatorial therapeutic strategies. Its final section, which explores future directions, elaborates on the possibility of enhancing HDAC inhibitors’ therapeutic efficacy against various neurological complications.

Автор: Castelo-Branco, Pedro
Название: Histone Modifications In Therapy
ISBN: 0128164220 ISBN-13(EAN): 9780128164228
Издательство: Elsevier Science
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Цена: 162820.00 T
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Описание:

Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment.