Histone Methyltransferases, Margueron

Автор: Wu, Carl
Название: Nucleosomes, Histones And Chromatin Part B,513
ISBN: 012391938X ISBN-13(EAN): 9780123919380
Издательство: Elsevier Science
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Цена: 154960.00 T
Наличие на складе: Нет в наличии.
Описание: Part of the Methods in Enzymology series, this title covers Nucleosomes, Histones & Chromatin and has chapters on Dynamic mapping of histone-DNA interactions in nucleosomes by unzipping single molecules of DNA, Digital DNase technology, and Genome-wide Analysis of Chromatin Transition.

Автор: Jeltsch
Название: DNA Methyltransferases - Role and Function
ISBN: 3031114531 ISBN-13(EAN): 9783031114533
Издательство: Springer
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Цена: 214280.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This 2nd edition of the book on DNA methyltransferases has been comprehensively updated to reflect many novel research findings regarding the structure, function, and technology of these enzymes that have emerged over the past 6 years. Like the previous edition, this 2nd edition explains the biochemical properties of DNA methyltransferases, describing their structures, mechanisms and biological roles in bacteria, humans and plants. It also discusses the biological processes of reading DNA methylation and the mechanisms of DNA demethylation. This volume highlights the newest findings on DNA methyltransferase inhibitors and their use in cancer therapy as well as the latest epigenome editing systems based on these enzymes. Overall, this 2nd edition comprehensively summarizes the current state of research in the field of DNA methylation and DNA methyltransferase and is essential reading for early career and advanced researchers in this exciting field.

Автор: Wu, Carl
Название: Nucleosomes, Histones And Chromatin Part A,512
ISBN: 0123919401 ISBN-13(EAN): 9780123919403
Издательство: Elsevier Science
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Цена: 154960.00 T
Наличие на складе: Нет в наличии.
Описание: Part of the Methods in Enzymology series, this title covers Nucleosomes, Histones & Chromatin and has chapters on Methods applied to the High resolution identification of intra- and interchromosomal DNA interactions by 4C technology, and peptide arrays to interrogate the binding specificity of chromatin-binding proteins.

Автор: Castelo-Branco, Pedro
Название: Histone Modifications In Therapy
ISBN: 0128164220 ISBN-13(EAN): 9780128164228
Издательство: Elsevier Science
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Цена: 162820.00 T
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Описание:

Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment.

Автор: Grant, Steven
Название: Histone Deacetylase Inhibitors As Cancer Therapeutics,116
ISBN: 0123943876 ISBN-13(EAN): 9780123943873
Издательство: Elsevier Science
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Цена: 116780.00 T
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Описание: Provides information on the exciting and fast-moving field of cancer research.

Автор: Shabir Ahmad Ganai
Название: Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders
ISBN: 981138021X ISBN-13(EAN): 9789811380211
Издательство: Springer
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Цена: 93160.00 T
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Описание: It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders.

Автор: Shabir Ahmad Ganai
Название: Histone Deacetylase Inhibitors — Epidrugs for Neurological Disorders
ISBN: 981138018X ISBN-13(EAN): 9789811380181
Издательство: Springer
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Цена: 130430.00 T
Наличие на складе: Нет в наличии.
Описание: This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders. The book explores the potential use of these inhibitors as novel therapeutic agents, considers the current challenges involved in using them to tackle neurological complications, and offers a novel solution by designing isoform-selective inhibitors and employing combinatorial therapeutic strategies. Its final section, which explores future directions, elaborates on the possibility of enhancing HDAC inhibitors’ therapeutic efficacy against various neurological complications.