Автор: Kinghorn A. Douglas, Falk Heinz, Gibbons Simon Название: Antimalarial Natural Products ISBN: 3030898725 ISBN-13(EAN): 9783030898724 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature’s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.
Автор: Patrick, Graham Название: The Design and Synthesis of Antimalarial Agents ISBN: 0081012101 ISBN-13(EAN): 9780081012109 Издательство: Elsevier Science Рейтинг: Цена: 179660.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
The Design and Synthesis of Antimalarial Agents is a comprehensive yet accessible guide for all those involved in the design, development and administration of antimalarial drugs. The book aims to support medicinal chemists in the search for improved and novel antimalarial drugs, providing practical guidance on current developments and highlighting promising leads. Beginning with a focus on biological aspects of malaria, early chapters include a description of the lifecycle of the parasite responsible for malaria, the problem of resistance, combinational therapy, genetic mapping of the parasite's genome, established drug targets, and potential drug targets for the future.
Malaria is a deadly disease which threatens half of the world's population. Advances over the last decade have seen vast improvements in the effectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential.
The Design and Synthesis of Antimalarial Agents covers the medicinal chemistry of antimalarial agents in detail, with a focus on the design of antimalarial drugs supported by a review of the drug categories that have reached the market, as well as those in the pipeline. Finally, the synthesis of different classes of antimalarial agents is reviewed, including a discussion on chemical and process development.
Consolidates current developments in the discovery, design, and synthesis of antimalarial drugs for the first time
Presents content in a style that is both thorough and engaging, supporting and encouraging students and researchers from interdisciplinary backgrounds
Highlights which drug targets are currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected
Автор: Tu, Youyou (professor, China Academy Of Traditional Chinese Medicine, Beijing, China) Название: From artemisia annua l. to artemisinins ISBN: 0128116552 ISBN-13(EAN): 9780128116555 Издательство: Elsevier Science Рейтинг: Цена: 132500.00 T Наличие на складе: Поставка под заказ. Описание:
From Artemisia annua L. to Artemisinins: The Discovery and Development of Artemisinins and Antimalarial Agents is the first book that systematically introduces the origin and development of artemisinine and artemisinine-based drugs. It includes four distinct sections, including Artemisia annua L., Artemisinin, Dihydroartemisinin, and other artemisinin derivatives. Tu Youyou, the chief inventor of artemisinin, together with other members from the research team, have written a book that will be a valuable reference work for both researchers involved in the medical industry and scholars who are interested in undertaking innovative research.
Автор: Henry M. Staines; Sanjeev Krishna Название: Treatment and Prevention of Malaria ISBN: 3034808089 ISBN-13(EAN): 9783034808088 Издательство: Springer Рейтинг: Цена: 174130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs.
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