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The Kappa Opioid Receptor, Liu-Chen


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Автор: Liu-Chen
Название:  The Kappa Opioid Receptor
ISBN: 9783030890766
Издательство: Springer
Классификация:
ISBN-10: 3030890767
Обложка/Формат: Soft cover
Страницы: 577
Вес: 1.05 кг.
Дата издания: 10.12.2022
Серия: Handbook of Experimental Pharmacology
Язык: English
Издание: 1st ed. 2022
Иллюстрации: 30 tables, color; 30 illustrations, color; 70 illustrations, black and white; xi, 577 p. 100 illus., 30 illus. in color.
Размер: 235 x 155
Читательская аудитория: Professional & vocational
Основная тема: Biomedicine
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Описание: This book covers the latest knowledge in structure, signaling, and biochemical pharmacology of KOR as well as preclinical research and clinical applications (including clinical phase studies and approved for human use) of KOR compounds. It is divided up into the three parts: Molecular aspects of KOR, Preclinical research on pharmacology of KOR agonists and antagonists in animals and KOR agonists and antagonists in clinical use and in past and present clinical trials. The chapters Biosensors monitor ligand-selective effects at kappa opioid receptors and The role of dynorphin and the kappa opioid receptor in schizophrenia and major depressive disorder: a translational approach of this book are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Дополнительное описание: From the contents. Preface.-Part I: Molecular aspects of KOR.- Part II: Preclinical research on pharmacology of KOR agonists and antagonists in animals.- Part III: KOR agonists and antagonists in clinical use and in past and present clinical trials.


The Kappa Opioid Receptor

Автор: Liu-Chen
Название: The Kappa Opioid Receptor
ISBN: 3030890732 ISBN-13(EAN): 9783030890735
Издательство: Springer
Рейтинг:
Цена: 130430.00 T
Наличие на складе: Поставка под заказ.
Описание: This book covers the latest knowledge in structure, signaling, and biochemical pharmacology of KOR as well as preclinical research and clinical applications (including clinical phase studies and approved for human use) of KOR compounds.

Allosteric Receptor Modulation In Drug Targeting

Автор: Bowery Norman G
Название: Allosteric Receptor Modulation In Drug Targeting
ISBN: 0824727916 ISBN-13(EAN): 9780824727918
Издательство: Taylor&Francis
Рейтинг:
Цена: 193950.00 T
Наличие на складе: Невозможна поставка.
Описание: Allosteric Receptor Modulation in Drug Targeting

Delta Opioid Receptor Pharmacology and Therapeutic Applications

Автор: Jutkiewicz
Название: Delta Opioid Receptor Pharmacology and Therapeutic Applications
ISBN: 3319951319 ISBN-13(EAN): 9783319951317
Издательство: Springer
Рейтинг:
Цена: 107130.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system. Part 2 describes new insights into the localization and trafficking of the DOR and how ligand-directed signaling alters the fate of the receptor. Part 3 concentrates on the potential role of the DOR system in disease states, such as pain, mood, addiction, and Parkinson’s disease. Throughout the book, the DOR system as a target for drug development will be discussed.

Delta Opioid Receptor Pharmacology and Therapeutic Applications

Автор: Emily M. Jutkiewicz
Название: Delta Opioid Receptor Pharmacology and Therapeutic Applications
ISBN: 303006980X ISBN-13(EAN): 9783030069803
Издательство: Springer
Рейтинг:
Цена: 107130.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system. Part 2 describes new insights into the localization and trafficking of the DOR and how ligand-directed signaling alters the fate of the receptor. Part 3 concentrates on the potential role of the DOR system in disease states, such as pain, mood, addiction, and Parkinson’s disease. Throughout the book, the DOR system as a target for drug development will be discussed.

Chemokine Receptors and NeuroAIDS

Автор: Olimpia Meucci
Название: Chemokine Receptors and NeuroAIDS
ISBN: 1489984879 ISBN-13(EAN): 9781489984876
Издательство: Springer
Рейтинг:
Цена: 158380.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Since their discovery as HIV co-receptors in 1996, chemokine receptors have been widely studied within the field of HIV pathogenesis, including neuroAIDS. However, though their role in infection of target cells and in inflammatory/immune responses is relatively well-characterized, their relevance with respect to neuropathogenesis is still unclear.

Functional Selectivity of G Protein-Coupled Receptor Ligands

Автор: Kim Neve
Название: Functional Selectivity of G Protein-Coupled Receptor Ligands
ISBN: 1493961160 ISBN-13(EAN): 9781493961160
Издательство: Springer
Рейтинг:
Цена: 174130.00 T
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Описание: In Functional Selectivity of G Protein-Coupled Receptors, experts review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon.

Opioid Receptors

Автор: Santi M. Spampinato
Название: Opioid Receptors
ISBN: 1493955500 ISBN-13(EAN): 9781493955503
Издательство: Springer
Рейтинг:
Цена: 111790.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Opioid Receptors: Methods and Protocols serves as a comprehensive guide to both key new techniques and established methods for the investigation of genetics, structural biology, transcription, and post-transcriptional events of opioid receptors. Other methods cover the cellular detection and trafficking of opioid receptors in vitro and in vivo. Procedures aimed to investigate signaling pathways modulated by opioid receptors and model systems to study opioid receptor-mediated functions are also included. Finally, methods to assay behavioral effects mediated by opioid receptors are described. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective introductions, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Wide-ranging and authoritative, Opioid Receptors: Methods and Protocols will help both experienced and new entrants in this field to carry out their experiments successfully and with new inspiration.

Opioid Analgesics

Автор: A.F. Casy; R.T. Parfitt
Название: Opioid Analgesics
ISBN: 0306421305 ISBN-13(EAN): 9780306421303
Издательство: Springer
Рейтинг:
Цена: 243800.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The rapidly burgeoning research of the past two decades on agonist-antagonist analgesics and opioid receptors makes this exhaustive review of opioid anal- gesics particularly relevant and timely.

Opioid Analgesics

Автор: A.F. Casy; R.T. Parfitt
Название: Opioid Analgesics
ISBN: 1489905871 ISBN-13(EAN): 9781489905871
Издательство: Springer
Рейтинг:
Цена: 186330.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The rapidly burgeoning research of the past two decades on agonist-antagonist analgesics and opioid receptors makes this exhaustive review of opioid anal­ gesics particularly relevant and timely. After an introductory chapter the additional 12 chapters begin logically with morphine and congeners (4- epoxymorphinans) and end with opioid receptors. All principal chemical types of centrally acting analgesics (including endogenous opioid-like substances) and their antagonists as well as the mixed agonist-antagonists are treated thoroughly, although not always (and for good reason) in historical (chrono­ logical) order. A chapter on miscellaneous types (atypical structures for the most part) includes the benzimidazoles (etonitazene), aminotetralins (dezocine), tetrahydroisoquinolines (methopholine), and so on. Important aspects and correlations of chemistry, pharmacology, and biochemistry are discussed in depth. Literature citations are numerous. For educators, practicing laboratory scientists, and physicians, this scholarly review by two authors well of opioid analgesics versed in the chemistry, pharmacology, and biochemistry will be informative, stimulating, and thought-provoking. Everette L. May Medical College of Virginia Richmond, VA 23298 v Preface The history of opium predates the written word, although knowledge of its constituents dates back less than 200 years. Over the centuries its popularity for the relief of pain has waxed and waned, until today the opiates are widely recognized as excellent analgesics but with disadvantages that have impaired their use seriously. There is a clear need for a potent analgesic with minimal effects on the respiratory centers and gastrointestinal tract and preferably devoid of dependence liability.

Textbook of Receptor Pharmacology

Автор: Foreman J.
Название: Textbook of Receptor Pharmacology
ISBN: 0849310296 ISBN-13(EAN): 9780849310294
Издательство: Taylor&Francis
Рейтинг:
Цена: 87790.00 T
Наличие на складе: Нет в наличии.
Описание: The bestselling first edition of Textbook of Receptor Pharmacology originated from a renowned course in receptor pharmacology taught at the University College of London for the past three decades. Its innovative format united four major approaches to the study of receptors: molecular biology, quantitative functional studies of agonists and antagonists, ligand binding, and signal transduction systems. The second edition builds on this foundation.This edition streamlines the material and focuses on cell membrane receptors along with their immediate signal transducers. The section on the molecular structure of receptors reflects the advances in this area. This edition also includes two restructured new chapters, one on G-proteins and one on tyrosine kinases, as signal transductors. Several chapters also contain problems for students to solve as well as worked-out solutions.The book contains over one hundred useful diagrams and tables to aid illustration of concepts and a helpful appendix explaining the simple mathematics used in the text. A time-saving resource and comprehensive textbook, Textbook of Receptor Pharmacology, Second Edition provides in-depth, up-to-date coverage of this

G Protein-Coupled Receptor Signaling

Автор: Mario Tiberi
Название: G Protein-Coupled Receptor Signaling
ISBN: 1493991205 ISBN-13(EAN): 9781493991204
Издательство: Springer
Рейтинг:
Цена: 167700.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed volume assembles comprehensive protocols to assist with the study of structural, molecular, cell biological, and in vivo facets of GPCRs, and to enable the development of experimental tools for screening novel GPCR drugs. Sections explore the tweaking of ligands, bioluminescence and FRET approaches, specific GPCR signaling properties, as well as visualization of subcellular compartmentalization. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, G Protein-Coupled Receptor Signaling: Methods and Protocols serves as an ideal reference for life scientists working in a variety of research fields including molecular pharmacology, cell and developmental biology, brain behavior and physiology, drug development and screening.
Chapter 4 is available open access under a CC BY 4.0 license via link.springer.com.

Receptor Binding in Drug Research

Автор: O`Brien, Robert A.
Название: Receptor Binding in Drug Research
ISBN: 0824775481 ISBN-13(EAN): 9780824775483
Издательство: Taylor&Francis
Рейтинг:
Цена: 331760.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.


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