Virus Entry Inhibitors, Jiang

Автор: Alexey Larionov
Название: Resistance to Aromatase Inhibitors in Breast Cancer
ISBN: 3319179713 ISBN-13(EAN): 9783319179711
Издательство: Springer
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Цена: 130430.00 T
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Описание: Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.

Автор: H.-W. Denker
Название: Implantation
ISBN: 3540084797 ISBN-13(EAN): 9783540084792
Издательство: Springer
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Цена: 93160.00 T
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Описание: On one hand, we have fairly well substantiated experimental and clinical evidence that the efficacy of these contraceptives lies with other factors as well, for example their influence on sperm migration and capacitation or their influence on the transportation of the unfertilized egg.

Автор: Robert B. Sim
Название: Activators and Inhibitors of Complement
ISBN: 9401052247 ISBN-13(EAN): 9789401052245
Издательство: Springer
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Цена: 191560.00 T
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Автор: Taotao Zou
Название: Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)
ISBN: 9811006563 ISBN-13(EAN): 9789811006562
Издательство: Springer
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Цена: 95770.00 T
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Описание: Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol "switch-on" probes and anti-cancer agents;

Автор: Maheshwari
Название: Natural Products as Enzyme Inhibitors
ISBN: 9811909318 ISBN-13(EAN): 9789811909313
Издательство: Springer
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Цена: 139750.00 T
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Описание: Chapters in this book cover topics such as plant-derived inhibitors of serine proteases, pancreatic lipase (PL) inhibitors from indigenous medicinal plants, amylase inhibitors and their applications in agriculture and food processing industries and advances in silico techniques used in the study of enzyme inhibitors.

Автор: Michel Pairet; Joanne van Ryn
Название: COX-2 Inhibitors
ISBN: 3034896077 ISBN-13(EAN): 9783034896078
Издательство: Springer
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Цена: 139750.00 T
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Описание: COX-2 inhibitors are important drugs with analgesic and anti-inflammatory effects. This book presents both pre-clinical and clinical information and is important for clinicians interested in the latest information about this class of drugs, for researchers and for students in the field.

Автор: Lyubomir Vassilev; David Fry
Название: Small-Molecule Inhibitors of Protein-Protein Interactions
ISBN: 3642266703 ISBN-13(EAN): 9783642266706
Издательство: Springer
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Цена: 174130.00 T
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Описание: In this volume, the editors have collected the knowledgeable insights of researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions.

Автор: Alexey Larionov
Название: Resistance to Aromatase Inhibitors in Breast Cancer
ISBN: 3319382845 ISBN-13(EAN): 9783319382845
Издательство: Springer
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Цена: 121890.00 T
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Описание: Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance.

Автор: Nicola J. Curtin; Ricky A. Sharma
Название: PARP Inhibitors for Cancer Therapy
ISBN: 3319141503 ISBN-13(EAN): 9783319141503
Издательство: Springer
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Цена: 158380.00 T
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Описание: PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer.

Автор: Mettenleiter, Thomas
Название: Virus Entry,104
ISBN: 0128183942 ISBN-13(EAN): 9780128183946
Издательство: Elsevier Science
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Цена: 150470.00 T
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Описание:

Virus Entry, Volume 104, the latest release in the Advances in Virus Research series, highlights new advances in the field, with this new volume presenting interesting chapters on plant virus cell-to-cell entry, plant virus entry via insect transmission, VSV/Rabies virus entry, Papovavirus entry, New approaches to study fusion proteins, Hantavirus receptors, Gamma Herpesvirus entry, and many other interesting topics.