Автор: Orrenius Название: Mitochondrial Signaling in Health and Disease ISBN: 1439880026 ISBN-13(EAN): 9781439880029 Издательство: Taylor&Francis Рейтинг: Цена: 193950.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis.
With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include:
Electron transport and energy production
Mitochondrial biogenesis and dynamics
Mitochondrial signaling
Apoptosis and autophagy
Pharmacology signaling
Epigenetic signaling: mitochondrial methylation and acetylation reactions
An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Автор: Tahira Farooqui Название: Oxidative Stress in Vertebrates and Invertebrates: Molecular Aspects of Cell Signaling ISBN: 111800194X ISBN-13(EAN): 9781118001943 Издательство: Wiley Рейтинг: Цена: 161510.00 T Наличие на складе: Поставка под заказ. Описание: This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy.
Автор: Emanuele Albano; Maurizio Parola Название: Studies on Hepatic Disorders ISBN: 3319155385 ISBN-13(EAN): 9783319155388 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume examines the current state of free radical biology as it impacts on hepatic disorders. It takes a thorough look at the relationship of oxidative stress in acute and chronic disease and takes into account factors like: redox biomarkers; antioxidant defense and protection; cell signaling, mutations; oxidative damage involving lipids, proteins and nucleic acids; membrane trafficking, inflammation, mitochondrial dysfunction, alterations in immunological function and toxicology and hypoxia. Studies on Hepatic Disorders, the latest volume in the Oxidative Stress in Basic Research and Clinical Practice series, provides a comprehensive look at liver topics. It is organized into four sections, each one thoroughly covering its topic and consisting of chapters written by recognized field leaders. Section One, covers basic principles including redox signaling, antioxidant defenses, nitric oxide, oxidative mechanisms in senescence and regeneration and the detection of oxidative stress. Section Two, explores Pathophysiology. It ranges from cell damage to fibrogenic response as broken out in chapters on hepatocellular injury, mitochondrial damage, unfolded protein response and autophagy, inflammation, ischemia-reperfusion injury and finally, fibrogenesis. Sections Three and Four cover specific diseases and cancer, respectively. Most of the chapters focus on diseases including acute failure, alcoholic disease, viral hepatitis, iron overload, autoimmune disease, Wilson’s disease and more, while the chapters on cancer round out the book.
Автор: Stephen M. Roberts; James P. Kehrer; Lars-Oliver K Название: Studies on Experimental Toxicology and Pharmacology ISBN: 331934708X ISBN-13(EAN): 9783319347080 Издательство: Springer Рейтинг: Цена: 121890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book focuses on data describing the roles of free radicals and related reactive species, and antioxidants, in the causes and treatments of diseases, examining both clinical and pre-clinical trials, as well as basic research.
Автор: Packer, Lester Название: Micronutrients and Brain Health ISBN: 1420073516 ISBN-13(EAN): 9781420073515 Издательство: Taylor&Francis Рейтинг: Цена: 224570.00 T Наличие на складе: Нет в наличии.
Автор: Chen, Qi Название: Vitamin C ISBN: 1032175257 ISBN-13(EAN): 9781032175256 Издательство: Taylor&Francis Рейтинг: Цена: 48990.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Chakraborti Sajal, Ray Bimal K., Roychoudhury Susanta Название: Handbook of Oxidative Stress in Cancer: Mechanistic Aspects ISBN: 9811594104 ISBN-13(EAN): 9789811594106 Издательство: Springer Рейтинг: Цена: 1304370.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This comprehensive, up-to-date reference work compiles the scientific research on the relationship between various forms of cancer and reactive oxygen species (ROS). It is well known that ROS play a key role in the various steps leading to malignancy, this includes increase in DNA mutation rates. The book brings together exciting reviews, written by leading experts all over the world. The book is divided into four broad sections. Each section describes the role of oxidative stress and underlying mechanisms and pathways, at various stages of cancer, including its role in carcinogenesis, cancer progression and metastasis. Further, the book describes how the reactive oxygen species (ROS) modulate gene expression and signal transduction pathways in cancer. The book discusses the ways to interfere with the cancer progression, and design of anti-cancer drugs. The book provides an integrated approach for better understanding of the development phases of oxidative stress-induced cancers, and mainly the current perspectives about mechanistic aspects of cancer initiation, progression and metastasis. It is a highly resourceful book and would be extremely important to clinicians, students and researchers in the field of cancer genetics, therapeutics and oncology.
Автор: Chakraborti Sajal, Dhalla Naranjan S., Dikshit Madhu Название: Modulation of Oxidative Stress in Heart Disease ISBN: 9811389489 ISBN-13(EAN): 9789811389481 Издательство: Springer Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease.
Автор: Huang Canhua, Zhang Yuanyuan Название: Oxidative Stress: Human Diseases and Medicine ISBN: 9811605211 ISBN-13(EAN): 9789811605215 Издательство: Springer Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing.
Автор: Maurya Pawan K., Dua Kamal Название: Role of Oxidative Stress in Pathophysiology of Diseases ISBN: 9811515670 ISBN-13(EAN): 9789811515675 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Chapter 1. Preface.- Chapter 2.Introduction.- Chapter 2.1. Oxidative stress and its biological significance.- Chapter 2.2. Free radicals and biological systems.- Chapter 2.3.Oxidative stress balance system.- Chapter 3. Role of oxidative stress in aging process.- Chapter 4. Oxidative stress in diseases.- Chapter 4.1. Oxidative stress in neurology and in neurodegenerative processes.- Chapter 4.2. Oxidative stress and Cardiology.- Chapter 4.3. Oxidative stress in chronic kidney disease.- Chapter 4.4.Oxidative Stress and Atherosclerosis.- Chapter 4.5. Oxidative stress and cancer.- Chapter 4.6. Oxidative stress in respiratory diseases.- Chapter 4.7. Oxidative stress and epigenetics.- Chapter 5. Oxidative stress monitoring using in vitro and in vivo models.- Chapter 6. Detection of oxidative stress biomarkers using biosensors.- Chapter 7. Pharmaceutical treatments and strategies for anti-oxidative stress.- Chapter 8. Effects of exercise training to the oxidative stress treatment.- Chapter 9. Advancements in novel drug delivery systems: Providing a challenge and threat to oxidative stress in various diseases.- Chapter 10. Future prospects and challenges.- Chapter 11. Bibliography.- Chapter 12. Glossary.
Автор: Chakraborti Sajal, Dhalla Naranjan S., Dikshit Madhu Название: Modulation of Oxidative Stress in Heart Disease ISBN: 9811389454 ISBN-13(EAN): 9789811389450 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.
Название: Glutathione ISBN: 036765699X ISBN-13(EAN): 9780367656997 Издательство: Taylor&Francis Рейтинг: Цена: 51030.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization.
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