Studies of Epithelial Transporters and Ion Channels, Hamilton

Автор: Kirk L. Hamilton; Daniel C Devor
Название: Ion Channels and Transporters of Epithelia in Health and Disease
ISBN: 1493933647 ISBN-13(EAN): 9781493933648
Издательство: Springer
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Цена: 232910.00 T
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Описание: This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters.

Автор: Hamilton Kirk L., Devor Daniel C.
Название: Studies of Epithelial Transporters and Ion Channels: Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 3
ISBN: 3030554538 ISBN-13(EAN): 9783030554538
Издательство: Springer
Цена: 130430.00 T
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Описание: This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract.

Автор: Hamilton Kirk L., Devor Daniel C.
Название: Ion Transport Across Epithelial Tissues and Disease: Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 2
ISBN: 3030553124 ISBN-13(EAN): 9783030553128
Издательство: Springer
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Цена: 121110.00 T
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Описание: This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract.

Автор: Hamilton Kirk L., Devor Daniel C.
Название: Ion Transport Across Epithelial Tissues and Disease: Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 2
ISBN: 3030553094 ISBN-13(EAN): 9783030553098
Издательство: Springer
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Цена: 121110.00 T
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Описание: This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract.

Автор: Hamilton Kirk L., Devor Daniel C.
Название: Basic Epithelial Ion Transport Principles and Function: Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 1
ISBN: 3030527794 ISBN-13(EAN): 9783030527792
Издательство: Springer
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Цена: 93160.00 T
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Описание: This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their contribution to maintaining homeostasis. Readers will be introduced to the fundamentals of ion transport in terms of function, modelling, regulation, structure and pharmacology. This is the first of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on basic fundamentals of epithelial transport physiology. There is a range of chapters dedicated to specific aspects of epithelial ion transport and cell function. Accordingly, the authors discuss techniques used to determine epithelial function, principles of epithelia transport, polarization of epithelial cells, mathematical modelling of epithelial ion transport, protein folding of ion channels, degradation epithelial ion channels, fundamentals of epithelial sodium, potassium and chloride transport, fundamentals of bicarbonate secretion, volume regulation, and microRNA regulation of epithelial channels and transporters. Given its scope, Volume 1 offers a valuable resource for physiology students, scientists and clinicians alike.

Автор: M. Morad; S. Ebashi; W. Trautwein; Yoshihisa Kurac
Название: Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters
ISBN: 0792339134 ISBN-13(EAN): 9780792339137
Издательство: Springer
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Цена: 427650.00 T
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Описание: This textbook offers an overview of structures and functions of ion channels and transporters in the heart. Among the topics covered in the work are the molecular biology and electrophysiology of all the important ion channels, and the pharmacology and pathophysiology of relevant ion channels.

Автор: Jason X. -J. Yuan; Jeremy P. T. Ward
Название: Membrane Receptors, Channels and Transporters in Pulmonary Circulation
ISBN: 1627038256 ISBN-13(EAN): 9781627038256
Издательство: Springer
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Цена: 307450.00 T
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Описание: Membrane Receptors, Channels and Transporters in Pulmonary Circulation is a proceeding of the 2008 Grover Conference (Lost Valley Ranch and Conference Center, Sedalia, Colorado; September 3-7, 2008), which provided a forum for experts in the fields of those receptors, channels and transporters that have been identified as playing key roles in the physiology and pathophysiology of the pulmonary circulation. The book rigorously addresses: i) recent advances in our knowledge of receptors, channels and transporters and their role in regulation of pulmonary vascular function; ii) how modulation of expression and function of receptors, channels and transporters and their interrelationships contribute to the pathogenesis of pulmonary vascular disease; and iii) the therapeutic opportunities that may be revealed by enhancing our understanding of this area. The overall goal was to explore the mechanisms by which specific receptors, channels and transporters contribute to pulmonary vascular function in both health and disease, and how this knowledge may lead to novel interventions in lung dysplasia, pulmonary edema, lung injury, and pulmonary and systemic hypertension to reduce and prevent death from lung disease. Membrane Receptors, Channels and Transporters in Pulmonary Circulation is divided into six parts. Part 1 (Ion Channels in the Pulmonary Vasculature: Basics and New Findings) is designated for basic knowledge and recent findings in the research field of ion channels in pulmonary circulation. There are five chapters in Part I discussing the function, expression, distribution and regulation of various ion channels present in pulmonary vascular smooth muscle cells and how these channels are integrated to regulate intracellular Ca2+ and cell functions. Part II (TRP Channels in the Pulmonary Vasculature: Basics and New Findings) is composed of five chapters that are exclusively designed to discuss the role of a recently identified family of cation channels, transient receptor potential (TRP) channels, in the regulation of pulmonary vascular tone and arterial structure. Part III (Pathogenic Role of Ion Channels in Pulmonary Vascular Disease) includes four chapters that discuss how abnormal function and expression of various ion channels contribute to changes in cell functions and the development of pulmonary hypertension. Part IV (Receptors and Signaling Cascades in Pulmonary Arterial Hypertension) consists of five chapters devoted to the role of bone morphogenetic protein receptors, Notch receptors, serotonin receptors, Rho kinase and vascular endothelial growth factor receptors in the development of pulmonary arterial hypertension. Part V (Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary Vasoconstriction) includes four chapters designed to illustrate the potential mechanisms involved in oxygen sensing and hypoxia-induced pulmonary vasoconstriction and hypertension. Part VI (Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular Disease) consists five chapters which discuss the translational research involving on membrane receptors, channels and transporters, including their potential as novel drug targets. We hope that Membrane Receptors, Channels and Transporters in Pulmonary Circulation will allow readers to foster new concepts and new collaborations and cooperations among investigators so as to further understand the role of receptors, channels and transporters in lung pathophysiology. The ultimate goal is to identify new mechanisms of disease, as well as new therapeutic targets for pulmonary vascular diseases. An additional outcome should be enhanced understanding of the role of these entities in systemic vascular pathophysiology, since the conference will include researchers and clinicians with interests in both pulmonary and systemic circulations.

Автор: Thomas Efferth
Название: Resistance to Targeted ABC Transporters in Cancer
ISBN: 3319098004 ISBN-13(EAN): 9783319098005
Издательство: Springer
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Цена: 139750.00 T
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Описание: This critical review volume explores the theme of ABC transporters in the context of basic cancer research and its role in drug-resistant tumors. The chapters provided complement basic research by including investigations from translational applications to clinical oncology. The development of resistance is a major obstacle in cancer chemotherapy and the field has been moving rapidly in terms of determining the mechanisms for blocking ABC transporter-mediated drug efflux by specific inhibitors and thereby overcoming multidrug resistance. The volume covers these issues in careful detail. Additional topics include the relevance of ABC transporters in resistance to novel and established anticancer drugs and prognosis of patients to compounds, compounds used in photodynamic therapy, tyrosine kinase inhibitors and others. Furthermore, the potential of radiopharmaceuticals for diagnosis of multidrug-resistant tumors and of nanotechnology to combat drug-resistant tumors is also discussed.

Автор: Hamilton Kirk L., Devor Daniel C.
Название: Basic Epithelial Ion Transport Principles and Function: Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 1
ISBN: 3030527824 ISBN-13(EAN): 9783030527822
Издательство: Springer
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Цена: 93160.00 T
Наличие на складе: Невозможна поставка.
Описание: 1. Techniques in Epithelial Transport.- 2. Understanding Transepithelial Current Measurements.- 3. Mathematical Modeling of Epithelial Ion Transport.- 4. Rationale of Epithelia Transport.- 5. Establishment of Epithelial Polarity.- 6. Molecular Mechanisms of Apical and Basolateral Sorting in Polarized Epithelial Cells.- 7. Membrane Protein Folding and Structure.- 8. Epithelial Ion Channel Folding and ER Associated Degradation (ERAD).- 9. Fundamentals of Epithelial Cl- Transport.- 10. Fundamentals of Epithelial Na+ Absorption.- 11. Physiologic Influences of Transepithelial K+ Secretion.- 12. Volume Regulation in Epithelia.- 13. Fundamentals of Bicarbonate Secretion in Epithelia.- 14. Sexual Dimorphism of Epithelial Ion Channels.- 15. Non-coding RNA-Dependent Regulation of Channels/Transporters.

Автор: Martin F. Fromm; Richard B. Kim
Название: Drug Transporters
ISBN: 3642266452 ISBN-13(EAN): 9783642266454
Издательство: Springer
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Цена: 279500.00 T
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Описание: Drug Transporters provides an overview of the most important transporter families for drug therapy. Each chapter is dedicated to a different transporter family, discussing tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.

Автор: Susan Napier; Matilda Bingham
Название: Transporters as Targets for Drugs
ISBN: 3642099696 ISBN-13(EAN): 9783642099694
Издательство: Springer
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Цена: 231990.00 T
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Описание: In each volume of Transporters as Targets for Drugs an overview chapter introduces the newcomer to the topic covered. The series covers hot topics of frontier research summarized by reputed scientists in the field.

Автор: Barbara J. Clark; Douglas M. Stocco
Название: Cholesterol Transporters of the START Domain Protein Family in Health and Disease
ISBN: 1493954032 ISBN-13(EAN): 9781493954032
Издательство: Springer
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Цена: 111790.00 T
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Описание: Non-vesicular intracellular cholesterol transport is an important mechanism for maintaining membrane cholesterol homeostasis. Recent reports of studies directed at soluble cholesterol transport proteins indicate that aberrant expression of the START proteins may contribute to disease states associated with disorders in cholesterol homeostasis.