Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters, M. Morad; S. Ebashi; W. Trautwein; Yoshihisa Kurac

Автор: Arpad Szallasi
Название: TRP Channels as Therapeutic Targets
ISBN: 0124200249 ISBN-13(EAN): 9780124200241
Издательство: Elsevier Science
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Цена: 154960.00 T
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Описание: TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. . This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. . An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. . Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings.

Автор: Baoxue Yang; Jeff M. Sands
Название: Urea Transporters
ISBN: 9401793425 ISBN-13(EAN): 9789401793421
Издательство: Springer
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Цена: 149060.00 T
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Описание: The mechanisms and physiological functions of urea transporters across biological membranes are subjects of long-standing interests. Although urea represents roughly 40% of all urinary solutes in normal human urine, the handling of urea in the tissues has been largely neglected in the past and few clinical or experimental studies now report data on urea. Most recent physiological text books include chapters on water and electrolyte physiology but no chapter on urea. Our aim in writing this book is to stimulate further research in new directions by providing novel and provocative insights into the further mechanisms and physiological significance of urea metabolism and transport in mammals. This book offers a state-of-the-art report on recent discoveries concerning urea transport and where the field is going. It mainly focuses on advances made over the past 20 years on the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of urea transport in mammalian cell membranes. It will help graduate students and researchers to get an overall picture of mammalian urea transporters and may also yield benefits for pharmaceutical companies with regard to drug discovery based on the urea transporter. Baoxue Yang is a professor and vice chairman of the Department of Pharmacology, Peking University. He is also an adjunct professor of Jilin University and a visiting professor of Northeast Normal University. Prof. Yang has been researching urea transporters for nearly 20 years and has published more than 70 original research articles in this field.

Автор: Giuliano Ciarimboli; Sophie Gautron; Eberhard Schl
Название: Organic Cation Transporters
ISBN: 3319237926 ISBN-13(EAN): 9783319237923
Издательство: Springer
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Цена: 139750.00 T
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Описание: This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.

Автор: Baoxue Yang; Jeff M. Sands
Название: Urea Transporters
ISBN: 9402402276 ISBN-13(EAN): 9789402402278
Издательство: Springer
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Цена: 149060.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The mechanisms and physiological functions of urea transporters across biological membranes are subjects of long-standing interests. Although urea represents roughly 40% of all urinary solutes in normal human urine, the handling of urea in the tissues has been largely neglected in the past and few clinical or experimental studies now report data on urea. Most recent physiological text books include chapters on water and electrolyte physiology but no chapter on urea. Our aim in writing this book is to stimulate further research in new directions by providing novel and provocative insights into the further mechanisms and physiological significance of urea metabolism and transport in mammals. This book offers a state-of-the-art report on recent discoveries concerning urea transport and where the field is going. It mainly focuses on advances made over the past 20 years on the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of urea transport in mammalian cell membranes. It will help graduate students and researchers to get an overall picture of mammalian urea transporters and may also yield benefits for pharmaceutical companies with regard to drug discovery based on the urea transporter. Baoxue Yang is a professor and vice chairman of the Department of Pharmacology, Peking University. He is also an adjunct professor of Jilin University and a visiting professor of Northeast Normal University. Prof. Yang has been researching urea transporters for nearly 20 years and has published more than 70 original research articles in this field.

Автор: Qing Yan
Название: Membrane Transporters in Drug Discovery and Development
ISBN: 1493957333 ISBN-13(EAN): 9781493957330
Издательство: Springer
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Цена: 139750.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Studies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development. Chapters include new and useful fields and methodologies, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and quantitative real-time-PCR. Transporter studies in drug discovery and development for various diseases are discussed, including neuropsychiatric disorders, cardiovascular diseases, ophthalmic diseases, cancer, and diabetes. Composed in the highly successful Methods in Molecular Biology™ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Wide-ranging and current, Membrane Transporters in Drug Discovery and Development: Methods and Protocols delivers a collection of practical protocols that can be used immediately in the lab, along with critical surveys of key topics by leading researchers in the field.

Автор: Martin F. Fromm; Richard B. Kim
Название: Drug Transporters
ISBN: 3642266452 ISBN-13(EAN): 9783642266454
Издательство: Springer
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Цена: 279500.00 T
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Описание: Drug Transporters provides an overview of the most important transporter families for drug therapy. Each chapter is dedicated to a different transporter family, discussing tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.

Автор: Levitan, PhD
Название: Vascular Ion Channels in Physiology and Disease
ISBN: 3319296337 ISBN-13(EAN): 9783319296333
Издательство: Springer
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Цена: 158380.00 T
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Описание: Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions. Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.

Автор: Stephen W. Schaffer; Ming Li
Название: T-type Calcium Channels in Basic and Clinical Science
ISBN: 3709119545 ISBN-13(EAN): 9783709119549
Издательство: Springer
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Цена: 113180.00 T
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Описание: The first full treatment of this developing field of research, this collection addresses new therapeutic concepts derived from work on the T-type calcium channel, its molecular, biophysical, and pharmacological properties, and its role in disease pathogenesis.

Автор: Norbert Weiss; Alexandra Koschak
Название: Pathologies of Calcium Channels
ISBN: 3662523531 ISBN-13(EAN): 9783662523537
Издательство: Springer
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Цена: 148010.00 T
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Описание: Calcium ions are crucial regulators of human physiology and development. This comprehensive guide to the molecular and clinical characteristics of the channels by which they cross membranes covers the diseases affecting them and a range of promising therapies.

Автор: Norbert Weiss; Alexandra Koschak
Название: Pathologies of Calcium Channels
ISBN: 364240281X ISBN-13(EAN): 9783642402814
Издательство: Springer
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Цена: 174150.00 T
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Описание: Calcium ions are crucial regulators of human physiology and development. This comprehensive guide to the molecular and clinical characteristics of the channels by which they cross membranes covers the diseases affecting them and a range of promising therapies.

Автор: Piero P. Foa; Mary F. Walsh
Название: Ion Channels and Ion Pumps
ISBN: 1461275997 ISBN-13(EAN): 9781461275992
Издательство: Springer
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Цена: 111790.00 T
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Описание: Omnis cellula e cellula, "every cell from a cell," was dogma to the 19th- century cellular physiologist and the cornerstone of Virchow`s Cellular- pathologie. "Spread out a cell into a layer and you will find that, in ceasing to be a cell, it has ceased to act as such," wrote the British 1 physiologist G .

Автор: M. P. Blaustein; O. Creutzfeldt; H. Grunicke; E. H
Название: Special Issue on Ionic Channels
ISBN: 3662311607 ISBN-13(EAN): 9783662311608
Издательство: Springer
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Цена: 74530.00 T
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