In Silico Methods for Predicting Drug Toxicity, Benfenati Emilio
Автор: Benfenati Название: In Silico Methods for Predicting Drug Toxicity ISBN: 1493936077 ISBN-13(EAN): 9781493936076 Издательство: Springer Рейтинг: Цена: 167700.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This detailed volume explores in silico methods forpharmaceutical toxicity by combiningthe theoretical advanced research with the practical application of the tools.Beginning with a section covering sophisticated models addressing the bindingto receptors, pharmacokinetics and adsorption, metabolism, distribution, andexcretion, the book continues with chapters delving into models for specifictoxicological and ecotoxicological endpoints, as well as broad views of themain initiatives and new perspectives which will very likely improve our way ofmodelling pharmaceuticals. Written for the highly successful Methods in Molecular Biology series,chapters include the kind of detailed implementation advice that is key forachieving successful research results.Authoritative and practical, In Silico Methods for Predicting DrugToxicity offers the advantage of incorporating data and knowledge fromdifferent fields, such as chemistry, biology, -omics, and pharmacology, toachieve goals in this vital area of research.
Автор: Emilio Benfenati Название: In Silico Methods for Predicting Drug Toxicity ISBN: 1493980939 ISBN-13(EAN): 9781493980932 Издательство: Springer Рейтинг: Цена: 102480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
1. QSAR Methods
Giuseppina Gini
Part I: Modeling a Pharmaceutical in the Human Body
2. In Silico 3D-Modelling of Binding Activities
Stefano Moro, Mattia Sturlese, Antonella Ciancetta, and Matteo Floris
3. Modeling Pharmacokinetics
Frederic Y. Bois and Cйline Brochot
4. Modeling ADMET
Jayeeta Ghosh, Michael S. Lawless, Marvin Waldman, Vijay Gombar, and Robert Fraczkiewicz
Part II: The Applications of In Silico Models for the Different Endpoints
5. In Silico Prediction of Chemically-Induced Mutagenicity: How to Use QSAR Models and Interpret Their Results
Enrico Mombelli, Giuseppa Raitano, and Emilio Benfenati
6. In Silico Methods for Carcinogenicity Assessment
Azadi Golbamaki and Emilio Benfenati
7. VirtualToxLab: Exploring the Toxic Potential of Rejuvenating Substances Found in Traditional Medicines
Martin Smiesko and Angelo Vedani
8. In Silico Model for Developmental Toxicity: How to Use QSAR Models and Interpret Their Results
Marco Marzo, Alessandra Roncaglioni, Sunil Kulkarni, Tara S. Barton-Maclaren, and Emilio Benfenati
9. In Silico Models for Repeated Dose Toxicity (RDT): Prediction of the No Observed Adverse Effect Level (NOAEL) and Lowest Observed Adverse Effect Level (LOAEL) for Drugs
Fabiola Pizzo and Emilio Benfenati
10. In Silico Models for Acute Systemic Toxicity
Julien Burton, Andrew P. Worth, Ivanka Tsakovska, and Antonia Diukendjieva
11. In Silico Models for Hepatotoxicity
Mark Hewitt and Katarzyna Przybylak
12. In SilicoModels for Ecotoxicity of Pharmaceuticals
Kunal Roy and Supratik Kar
13. Use of Read-Across Tools
Serena Manganelli and Emilio Benfenati
Part III: The Scientific and Society Challenges
14. Adverse Outcome Pathways as Tools to Assess Drug-Induced Toxicity
Mathieu Vinken
15. A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure
Dennie G.A.J. Hebels, Axel Rasche, Ralf Herwig, Gerard J.P. van Westen, Danyel G.J. Jennen, and Jos C.S. Kleinjans
16. In Silico Study of In Vitro GPCR Assays by QSAR Modeling
Kamel Mansouri and Richard S. Judson
17. Taking Advantage of Databases
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Автор: Robert M. Losee Название: Predicting Information Retrieval Performance ISBN: 1681734745 ISBN-13(EAN): 9781681734743 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 61910.00 T Наличие на складе: Невозможна поставка. Описание: Within the constraints of alien control or influence, it is argued, cultural and organisational barriers have consistently allowed a wide range of initiative to African leaders and communities in a creative and flexible adjustment to new and unfamiliar demands. Exploration of this African initiative in various contexts suggests a complex, fascinating pattern of cultural and structural interaction.
Автор: Robert M. Losee Название: Predicting Information Retrieval Performance ISBN: 1681734729 ISBN-13(EAN): 9781681734729 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 41580.00 T Наличие на складе: Невозможна поставка. Описание: Information Retrieval performance measures are usually retrospective in nature, representing the effectiveness of an experimental process. However, in the sciences, phenomena may be predicted, given parameter values of the system. After developing a measure that can be applied retrospectively or can be predicted, performance of a system using a single term can be predicted given several different types of probabilistic distributions. Information Retrieval performance can be predicted with multiple terms, where statistical dependence between terms exists and is understood. These predictive models may be applied to realistic problems, and then the results may be used to validate the accuracy of the methods used. The application of metadata or index labels can be used to determine whether or not these features should be used in particular cases. Linguistic information, such as part-of-speech tag information, can increase the discrimination value of existing terminology and can be studied predictively.This work provides methods for measuring performance that may be used predictively. Means of predicting these performance measures are provided, both for the simple case of a single term in the query and for multiple terms. Methods of applying these formulae are also suggested.
Автор: Henry Abarbanel Название: Predicting the Future ISBN: 1493952382 ISBN-13(EAN): 9781493952380 Издательство: Springer Рейтинг: Цена: 104480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book discusses model building and evaluation across disciplines, by means of an exact path integral for transferring information from observations to a model of the observed system. Offers examples in geosciences, nonlinear electrical circuits and more.
Автор: Toru Takebayashi; Robert Landsiedel; Masashi Gamo Название: In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials ISBN: 9811384320 ISBN-13(EAN): 9789811384325 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Невозможна поставка. Описание: This edited volume discusses the short-term inhalation study (STIS) and intratracheal administration, the two major in vivo inhalation-toxicity screening methods, which play an important role in efficient hazard evaluation. It also provides a general overview of the inhalation toxicity of nanomaterials and related issues. For each screening method, it provides up-to-date information on the test procedures, interpretation of the test results, useful applications, and related technologies. In view of the increasing variety of nanomaterials in practical use, the book offers a basis for building a framework for grouping and read-across assessments of nanomaterials.With contributions by academic and industrial experts, In vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials is a pragmatic reference resource for readers who are responsible for assessing the safety of nanomaterials in R&D and business, as well as researchers.
Автор: Takebayashi Toru, Landsiedel Robert, Gamo Masashi Название: In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials ISBN: 9811384355 ISBN-13(EAN): 9789811384356 Издательство: Springer Цена: 93160.00 T Наличие на складе: Невозможна поставка. Описание: This book is intended for periodontal residents and practicing periodontists who wish to incorporate the principles of moderate sedation into daily practice. Comprehensive airway management and rescue skills are then documented in detail so that the patient may be properly managed in the event that the sedation progresses beyond the intended level.
Автор: Palmeira Carlos Manuel Marques, de Oliveira Danielle Palma, Dorta Daniel Junqueira Название: Toxicity Assessment: Methods and Protocols ISBN: 1071610902 ISBN-13(EAN): 9781071610909 Издательство: Springer Цена: 107130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Given the ever-increasing exposure to different compounds and their effects on population health, the assessment of multiple endpoints is of utmost importance for better risk assessment, and this collection addresses that need.
Автор: Eskes Chantra, Whelan Maurice Название: Validation of Alternative Methods for Toxicity Testing ISBN: 3319816128 ISBN-13(EAN): 9783319816128 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing.
Автор: K.W. Bock; Frederick C. Kauffman; B. Burchell; M. Название: Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity ISBN: 3642784313 ISBN-13(EAN): 9783642784316 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In-depth coverage of advances in molecular biology, indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds. Part Two deals with the regulation of Phase II conjugation, while Part Three critically reviews the importance of drug conjugates in pharmacology and toxicology.
Автор: Robert J. Kavlock; George P. Daston Название: Drug Toxicity in Embryonic Development II ISBN: 3642644090 ISBN-13(EAN): 9783642644092 Издательство: Springer Рейтинг: Цена: 121890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: With contributions by numerous experts
Автор: Liu Название: Drug Transporters in Drug Disposition, Effects and Toxicity ISBN: 9811376468 ISBN-13(EAN): 9789811376467 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Поставка под заказ. Описание: This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field.
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