Validation of Alternative Methods for Toxicity Testing, Eskes Chantra, Whelan Maurice
Автор: Palmeira Carlos Manuel Marques, de Oliveira Danielle Palma, Dorta Daniel Junqueira Название: Toxicity Assessment: Methods and Protocols ISBN: 1071610902 ISBN-13(EAN): 9781071610909 Издательство: Springer Цена: 107130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Given the ever-increasing exposure to different compounds and their effects on population health, the assessment of multiple endpoints is of utmost importance for better risk assessment, and this collection addresses that need.
Автор: Benfenati Emilio Название: In Silico Methods for Predicting Drug Toxicity ISBN: 1071619594 ISBN-13(EAN): 9781071619599 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Divided into five sections, the volume covers the modeling of pharmaceuticals in the body, toxicity data for modeling purposes, in silico models for multiple endpoints, a number of platforms for evaluating pharmaceuticals, as well as an exploration of challenges, both scientific and sociological.
Автор: Balls, Michael; Combes, Robert D.; Bhogal, Nirmala (Eds.) Название: New Technologies for Toxicity Testing ISBN: 1461430542 ISBN-13(EAN): 9781461430544 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Поставка под заказ. Описание: The central theme running through this volume on New Technologies for Toxicity Testing is the development and application of advanced techniques for cell and tissue culture, as well as new markers and endpoints of toxicity, as alternatives to the traditional paradigm of relying on data from laboratory animal tests to undertake labelling and risk assessment. Of course, many of the techniques and methods described in this volume are in the early stages of development, and much work will be needed to ensure their further improvement, optimisation and validation. However, we are confident that this will be achieved and that, just as with the in vitro assays that were validated and granted regulatory acceptance over the last decade, these, and many other new, advanced methods, will likewise become part of the toxicologist’s improved toolbox for coping with increasingly stringent and numerous regulatory requirements and test chemicals, while placing less reliance on traditional testing paradigms.
Автор: Kathleen M. Gilbert; Sarah J. Blossom Название: Trichloroethylene: Toxicity and Health Risks ISBN: 1447163109 ISBN-13(EAN): 9781447163107 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases.
Автор: Kesari Название: Oxidative Stress and Toxicity in Reproductive Biology and Medicine ISBN: 3030893391 ISBN-13(EAN): 9783030893392 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book discusses the role of oxidative stress in human reproduction with a focus on men’s health. The physiological roles of reactive oxygen species (ROS) in male fertility are the focus in this book. This topic is important because oxidative stress is a result of the imbalance between ROS and antioxidants in the body which may lead to sperm damage (DNA or count), deformity, and eventually, male infertility. Therefore, for a better understanding of the molecular mechanisms related to male genotoxicity and its regulation in infertility, this book provides an up-to-date view on the impact of oxidative stress factors in male reproduction . The main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of ROS or oxidative stress in physiological and pathological states in relation to (in)fertility in the male. This book presents various state-of-the-art chapters of the recent progress in the field of cellular toxicology and clinical manifestations of various issues related to men’s health and fertility. Topics include cell signaling, DNA damage and infertility, the pathophysiology of disease instigation and distribution, immune toxicity and prevention.
Автор: Kathleen M. Gilbert; Sarah J. Blossom Название: Trichloroethylene: Toxicity and Health Risks ISBN: 1447172418 ISBN-13(EAN): 9781447172413 Издательство: Springer Рейтинг: Цена: 130590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases.
Автор: Weiner, Myra L. , Kotkoskie, Lois A. Название: Excipient Toxicity and Safety ISBN: 0367399318 ISBN-13(EAN): 9780367399313 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
This book reviews the history, regulatory status, pharmacopeial specifications, and harmonization of pharmaceutical excipients in the United States and Europe, and provides a comprehensive understanding of the current scientific basis for safety evaluation and risk assessment. Examines excipients as a unique class of products and explores new procedures for determining toxicity! A timely and unique addition to the pharmaceutical literature, containing over 570 citations that support and enhance the text, Excipient Toxicity and Safety
identifies the differences between excipients (inactive ingredients), food ingredients, and drug products
evaluates issues of dose administration, species selection, and study design for various routes of exposure
provides detailed information on the historical uses of excipients in drug formulations
clarifies the Safety Committee of the International Pharmaceutical Excipients Council's (IPEC) guidelines and technical specifications for conducting tests for each route of exposure
explains how data generated in toxicity models are applied to identify hazards in drug formulations
details exposure assessment to link hazard identification with risk
considers the requirements and importance of purity specifications
and much more! Excipient Toxicity and Safety is a blue-ribbon reference ideal for pharmacists; toxicologists; pharmacologists; analytical chemists; quality control, quality assurance, and regulatory compliance managers; and upper-level undergraduate and graduate students in these disciplines.
Автор: Cleophas Ton J., Zwinderman Aeilko H. Название: Clinical Data Analysis on a Pocket Calculator: Understanding the Scientific Methods of Statistical Reasoning and Hypothesis Testing ISBN: 3319800744 ISBN-13(EAN): 9783319800745 Издательство: Springer Рейтинг: Цена: 79190.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: In medical and health care the scientific method is little used, and statistical software programs are experienced as black box programs producing lots of p-values, but little answers to scientific questions. The pocket calculator analyses appears to be, particularly, appreciated, because they enable medical and health professionals and students for the first time to understand the scientific methods of statistical reasoning and hypothesis testing. So much so, that it can start something like a new dimension in their professional world. In addition, a number of statistical methods like power calculations and required sample size calculations can be performed more easily on a pocket calculator, than using a software program. Also, there are some specific advantages of the pocket calculator method. You better understand what you are doing. The pocket calculator works faster, because far less steps have to be taken, averages can be used. The current nonmathematical book is complementary to the nonmathematical "SPSS for Starters and 2nd Levelers" (Springer Heidelberg Germany 2015, from the same authors), and can very well be used as its daily companion.
Автор: Astrid Sigel; Helmut Sigel; Roland KO Sigel Название: Cadmium: From Toxicity to Essentiality ISBN: 9401780811 ISBN-13(EAN): 9789401780810 Издательство: Springer Рейтинг: Цена: 204040.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Volume 11 provides in an authoritative and timely manner in 16 stimulating chapters, written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research area. MILS-11 covers the bioinorganic chemistry of Cd(II), its biogeochemistry, anthropogenic release into the environment, and speciation in the atmosphere, waters, soils, and sediments. The analytical tools for Cd determination, its imaging in cells, and the use of 113Cd NMR to probe Zn(II) and Ca(II) proteins are summarized, as are Cd(II) interactions with nucleotides, nucleic acids, amino acids, and proteins including metallothioneins. The phytoremediation by Cd(II)-accumulating plants, etc., the toxicology of Cd(II), its damage to mammalian organs, and its role as a carcinogen for humans, are highlighted.
Автор: Vasanthy M., Sivasankar V., Sunitha T. G. Название: Organic Pollutants: Toxicity and Solutions ISBN: 3030724409 ISBN-13(EAN): 9783030724405 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume describes the identification of emerging organic pollutants, mainly from industrial sources, their associated toxicological threats, and the latest green methods and biotechnological solutions to abate harmful impacts on people and the environment.
Автор: Peter Greaves Название: Histopathology of Preclinical Toxicity Studies, ISBN: 0444538569 ISBN-13(EAN): 9780444538567 Издательство: Elsevier Science Рейтинг: Цена: 167310.00 T Наличие на складе: Поставка под заказ. Описание: Describes the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. This reference is suitable for those involved in drug safety evaluation, including pathologists, toxicologists, and pharmacologists.
Автор: Michael Balls; Robert D. Combes; Nirmala Bhogal Название: New Technologies for Toxicity Testing ISBN: 1493944193 ISBN-13(EAN): 9781493944194 Издательство: Springer Рейтинг: Цена: 174130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Featuring detailed insights into the latest techniques in toxicity testing, this volume covers several that both broaden its range and improve its sensitivity, at the same time as offering alternatives to traditional methods involving laboratory animal tests.
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