Validation of Alternative Methods for Toxicity Testing, Eskes Chantra, Whelan Maurice

Автор: Palmeira Carlos Manuel Marques, de Oliveira Danielle Palma, Dorta Daniel Junqueira
Название: Toxicity Assessment: Methods and Protocols
ISBN: 1071610902 ISBN-13(EAN): 9781071610909
Издательство: Springer
Цена: 107130.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Given the ever-increasing exposure to different compounds and their effects on population health, the assessment of multiple endpoints is of utmost importance for better risk assessment, and this collection addresses that need.

Автор: Benfenati Emilio
Название: In Silico Methods for Predicting Drug Toxicity
ISBN: 1071619594 ISBN-13(EAN): 9781071619599
Издательство: Springer
Рейтинг:
Цена: 149060.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Divided into five sections, the volume covers the modeling of pharmaceuticals in the body, toxicity data for modeling purposes, in silico models for multiple endpoints, a number of platforms for evaluating pharmaceuticals, as well as an exploration of challenges, both scientific and sociological.

Автор: Balls, Michael; Combes, Robert D.; Bhogal, Nirmala (Eds.)
Название: New Technologies for Toxicity Testing
ISBN: 1461430542 ISBN-13(EAN): 9781461430544
Издательство: Springer
Рейтинг:
Цена: 149060.00 T
Наличие на складе: Нет в наличии.
Описание: The central theme running through this volume on New Technologies for Toxicity Testing is the development and application of advanced techniques for cell and tissue culture, as well as new markers and endpoints of toxicity, as alternatives to the traditional paradigm of relying on data from laboratory animal tests to undertake labelling and risk assessment. Of course, many of the techniques and methods described in this volume are in the early stages of development, and much work will be needed to ensure their further improvement, optimisation and validation. However, we are confident that this will be achieved and that, just as with the in vitro assays that were validated and granted regulatory acceptance over the last decade, these, and many other new, advanced methods, will likewise become part of the toxicologist’s improved toolbox for coping with increasingly stringent and numerous regulatory requirements and test chemicals, while placing less reliance on traditional testing paradigms.

Автор: Michael Balls; Robert D. Combes; Nirmala Bhogal
Название: New Technologies for Toxicity Testing
ISBN: 1493944193 ISBN-13(EAN): 9781493944194
Издательство: Springer
Рейтинг:
Цена: 174130.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Featuring detailed insights into the latest techniques in toxicity testing, this volume covers several that both broaden its range and improve its sensitivity, at the same time as offering alternatives to traditional methods involving laboratory animal tests.

Автор: Astrid Sigel; Helmut Sigel; Roland KO Sigel
Название: Cadmium: From Toxicity to Essentiality
ISBN: 9401780811 ISBN-13(EAN): 9789401780810
Издательство: Springer
Рейтинг:
Цена: 204040.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Volume 11 provides in an authoritative and timely manner in 16 stimulating chapters, written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research area. MILS-11 covers the bioinorganic chemistry of Cd(II), its biogeochemistry, anthropogenic release into the environment, and speciation in the atmosphere, waters, soils, and sediments. The analytical tools for Cd determination, its imaging in cells, and the use of 113Cd NMR to probe Zn(II) and Ca(II) proteins are summarized, as are Cd(II) interactions with nucleotides, nucleic acids, amino acids, and proteins including metallothioneins. The phytoremediation by Cd(II)-accumulating plants, etc., the toxicology of Cd(II), its damage to mammalian organs, and its role as a carcinogen for humans, are highlighted.

Автор: Kathleen M. Gilbert; Sarah J. Blossom
Название: Trichloroethylene: Toxicity and Health Risks
ISBN: 1447163109 ISBN-13(EAN): 9781447163107
Издательство: Springer
Рейтинг:
Цена: 156720.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases.

Автор: Kesari
Название: Oxidative Stress and Toxicity in Reproductive Biology and Medicine
ISBN: 3030893391 ISBN-13(EAN): 9783030893392
Издательство: Springer
Рейтинг:
Цена: 139750.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book discusses the role of oxidative stress in human reproduction with a focus on men’s health. The physiological roles of reactive oxygen species (ROS) in male fertility are the focus in this book. This topic is important because oxidative stress is a result of the imbalance between ROS and antioxidants in the body which may lead to sperm damage (DNA or count), deformity, and eventually, male infertility. Therefore, for a better understanding of the molecular mechanisms related to male genotoxicity and its regulation in infertility, this book provides an up-to-date view on the impact of oxidative stress factors in male reproduction . The main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of ROS or oxidative stress in physiological and pathological states in relation to (in)fertility in the male. This book presents various state-of-the-art chapters of the recent progress in the field of cellular toxicology and clinical manifestations of various issues related to men’s health and fertility. Topics include cell signaling, DNA damage and infertility, the pathophysiology of disease instigation and distribution, immune toxicity and prevention.

Автор: Vasanthy M., Sivasankar V., Sunitha T. G.
Название: Organic Pollutants: Toxicity and Solutions
ISBN: 3030724409 ISBN-13(EAN): 9783030724405
Издательство: Springer
Рейтинг:
Цена: 130430.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume describes the identification of emerging organic pollutants, mainly from industrial sources, their associated toxicological threats, and the latest green methods and biotechnological solutions to abate harmful impacts on people and the environment.

Автор: Seiler
Название: In Situ Bioavailability and Toxicity of Organic Chemicals in Aquatic Systems
ISBN: 1071623524 ISBN-13(EAN): 9781071623527
Издательство: Springer
Рейтинг:
Цена: 111790.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed volume examines the complex study of the assessment of in situ bioavailability and toxicity of organic chemicals in aquatic systems with a toolbox of reliable techniques.

Автор: Kesari Kavindra Kumar, Jha Niraj Kumar
Название: Free Radical Biology and Environmental Toxicity
ISBN: 303083445X ISBN-13(EAN): 9783030834456
Издательство: Springer
Рейтинг:
Цена: 139750.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of free radical research and environmental toxicity.

Автор: Peter Greaves
Название: Histopathology of Preclinical Toxicity Studies,
ISBN: 0444538569 ISBN-13(EAN): 9780444538567
Издательство: Elsevier Science
Рейтинг:
Цена: 167310.00 T
Наличие на складе: Нет в наличии.
Описание: Describes the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. This reference is suitable for those involved in drug safety evaluation, including pathologists, toxicologists, and pharmacologists.

Автор: Kathleen M. Gilbert; Sarah J. Blossom
Название: Trichloroethylene: Toxicity and Health Risks
ISBN: 1447172418 ISBN-13(EAN): 9781447172413
Издательство: Springer
Рейтинг:
Цена: 130590.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases.