Biochemistry of Apoptosis and Autophagy, Kirshenbaum Lorrie A.
Автор: Iman Tavassoly Название: Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells ISBN: 331914961X ISBN-13(EAN): 9783319149615 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.
Автор: Donev Rossen Название: Apoptosis in Health and Disease - Part A, 125 ISBN: 0323853153 ISBN-13(EAN): 9780323853156 Издательство: Elsevier Science Рейтинг: Цена: 150470.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Apoptosis, or programmed cell death, is the mechanism by which cells die either physiologically or pathologically. A vast research in apoptosis has advanced our understanding of basic physiological and pathological processes occurring in cells, organs and organisms, and its role in a number of diseases. These new advanced understandings are playing a major influence in drug discovery and the introduction of new therapies that target this cell death process. These two thematic volumes 125 and 126 of the Advances in Protein Chemistry and Structural Biology focus on apoptotic responses in numerous conditions - from bacterial and parasite infections to pathological states such as oxidative stress, pulmonary hypertension, different cancer types, etc. Finally, therapeutic strategies for targeting apoptosis are also discussed.
Автор: Martin Tenniswood; Horst Michna Название: Apoptosis in Hormone-Dependent Cancers ISBN: 3662031248 ISBN-13(EAN): 9783662031247 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: It is now widely accepted that cells have the ability to initiate a program of gene-directed death, a process called "apoptosis" which may also be used as an innovative strategy for therapeutic intervention in cancer therapy.
Название: Apoptosis: The Molecular Biology of Programmed Cell Death ISBN: 0199638497 ISBN-13(EAN): 9780199638499 Издательство: Oxford Academ Рейтинг: Цена: 95040.00 T Наличие на складе: Поставка под заказ. Описание: This work is intended for postgraduate students in cell biology, postdoctoral researchers new to the field, advanced undergraduates, postgraduate medical students, and clinicians undertaking research training in the area.
Автор: Hong-Gang Wang Название: Autophagy and Cancer ISBN: 1489991778 ISBN-13(EAN): 9781489991775 Издательство: Springer Рейтинг: Цена: 148010.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book covers current advances in autophagy research, including such developments as molecular machinery for autophagy induction and regulation, how to target autophagy and modulation of autophagy and drug discovery for cancer prevention and treatment.
Автор: Green Douglas R. Название: Means to an End: Apoptosis and Other Cell Death Mechanisms ISBN: 0879698888 ISBN-13(EAN): 9780879698881 Издательство: Неизвестно Рейтинг: Цена: 33490.00 T Наличие на складе: Невозможна поставка. Описание: One million cells in our bodies die every secondthey commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Means To An End, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of the BCL-2 family of proteins and the role of cytochrome c released from mitochondria. The final stage of the process, phagocytic removal of dead or dying cells, is also covered. Green outlines the roles of apoptosis and death mechanisms such as necrosis in embryogenesis, neuronal selection, and the development of self-tolerance in the immune system. In addition, he explains how cell death defends the body against cancer and traces the evolutionary origins of the apoptosis machinery back over a billion years. The book is thus of great use to all biologists interested in how cells function in the context of multicellular organisms and will appeal to everyone from undergraduates encountering the topic for the first time to researchers actively working in the field.
Автор: Xie Zhiping Название: Autophagy: Biology and Diseases: Technology and Methodology ISBN: 9811628297 ISBN-13(EAN): 9789811628290 Издательство: Springer Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy.
Автор: Hayat, M. A. Название: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Inf ISBN: 0128054204 ISBN-13(EAN): 9780128054208 Издательство: Elsevier Science Рейтинг: Цена: 156080.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy.
Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections.
Presents the most advanced information regarding the role of the autophagic system in life and death
Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both
Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation
Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment
Includes chapters authored by leaders in the field around the globe--the broadest, most expert coverage available
Автор: Ross G. Cameron; George Feuer Название: Apoptosis and Its Modulation by Drugs ISBN: 3540661212 ISBN-13(EAN): 9783540661214 Издательство: Springer Рейтинг: Цена: 391830.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: with contributions by numerous experts
Автор: Zheng-Hong Qin Название: Autophagy: Biology and Diseases ISBN: 9811506019 ISBN-13(EAN): 9789811506017 Издательство: Springer Рейтинг: Цена: 204970.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development of molecular biology and omic technologies, research on autophagy has boomed in recent decades, and more and more cellular and animal models and state-of the-art technologies are being used to shed light on the complexity of signaling networks involved in the autophagic process. Further, its involvement in biological functions and the pathogenesis of various diseases has attracted increased attention around the globe. Presenting cutting-edge knowledge, this book series is a useful reference resource for researchers and clinicians who are working on or interested in autophagy.
Автор: Donev, Rossen Название: Apoptosis In Health And Disease - Part B,126 ISBN: 032385317X ISBN-13(EAN): 9780323853170 Издательство: Elsevier Science Рейтинг: Цена: 133620.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Apoptosis in Health and Disease - Part B, Volume 126 in the Advances in Protein Chemistry and Structural Biology focuses on apoptotic responses in numerous conditions - from bacterial and parasite infections, to pathological states such as oxidative stress, pulmonary hypertension, and different cancer types, etc. In addition, the book provides therapeutic strategies for targeting apoptosis. These new advanced understandings are playing a major influence in drug discovery and the introduction of new therapies that target the cell death process.
Apoptosis, or programmed cell death, is the mechanism by which cells die either physiologically or pathologically. Vast research in apoptosis has advanced our understanding of basic physiological and pathological processes occurring in cells, organs and organisms, and its role in a number of diseases.
Integrates experimental and computational methods for studying apoptosis in health and different diseases
Includes strategies for identification of suitable therapeutic targets
Discusses the design of treatments targeting key points in the apoptotic cascade
Название: Autophagy in differentiation and tissue maintenance ISBN: 149398747X ISBN-13(EAN): 9781493987474 Издательство: Springer Рейтинг: Цена: 102480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This detailed book compiles state-of-the-art protocols from researchers actively working in the area of autophagy, a crucial cellular process that regulates numerous cellular functions. In order to accelerate advances in the field, the volume explores aspects of autophagy research where a better understanding of its role is vitally important, such as in the maintenance of stem cell subpopulations and the regulation of differentiation. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Autophagy in Differentiation and Tissue Maintenance: Methods and Protocols serves as an ideal guide for researchers seeking to expand our knowledge of this key cell biological action.
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