Means to an End: Apoptosis and Other Cell Death Mechanisms 9780879698881

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Автор: Green Douglas R.
Название: Means to an End: Apoptosis and Other Cell Death Mechanisms
Перевод названия: Дуглас Грин: Апоптоз и другие механизмы клеточной смерти
ISBN: 9780879698881
Издательство: Cold Spring Harbor Laboratory Press
Классификация:

Анатомия

Физиология

Биология и науки о жизни

Клеточная биология (цитология)

ISBN-10: 0879698888
Обложка/Формат: Paperback
Вес: 0.42 кг.
Дата издания: 01.12.2010
Язык: English
Иллюстрации: Illustrations
Размер: 230 x 168 x 11
Читательская аудитория: General (us: trade)
Подзаголовок: Apoptosis and other cell death mechanisms
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Поставляется из: США
Описание: One million cells in our bodies die every secondthey commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Means To An End, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of the BCL-2 family of proteins and the role of cytochrome c released from mitochondria. The final stage of the process, phagocytic removal of dead or dying cells, is also covered. Green outlines the roles of apoptosis and death mechanisms such as necrosis in embryogenesis, neuronal selection, and the development of self-tolerance in the immune system. In addition, he explains how cell death defends the body against cancer and traces the evolutionary origins of the apoptosis machinery back over a billion years. The book is thus of great use to all biologists interested in how cells function in the context of multicellular organisms and will appeal to everyone from undergraduates encountering the topic for the first time to researchers actively working in the field.

Means to an End: Apoptosis and Other Cell Death Mechanisms, Green Douglas R.