Modern cns drug discovery, 

Название: Modern cns drug discovery
ISBN: 3031619919 ISBN-13(EAN): 9783031619915
Издательство: Springer
Цена: 74530 T
Описание: This new edition is a comprehensive guide to the intricate world of drug discovery and development. It provides readers with an update on basic and novel concepts, approaches and technologies that are used in the discovery and development of new therapeutics for diseases of the central nervous system (CNS). A major aim is to support the education of professionals and specialists in the biomedical neurosciences that will become the innovators, entrepreneurs, and leaders of the future. The educational focus is now enhanced by the inclusion of over 150 study questions available in the free Springer Nature Flashcard App, which makes this a unique book in its field. Divided into five sections, the book starts by introducing concepts and ideas to inspire the next generation of life scientists pursuing careers in drug discovery for CNS diseases.  In the following section, key strategies and methods for identifying and testing novel drug targets are described. New chapters on important topics have been added, that is, the blood brain barrier, mass spectrometry, biased signaling and the exposome. The third section highlights strategies and technologies in translational CNS drug discovery and looks at safety and drug metabolism assessment, imaging techniques and functional testing to investigate drug treatment outcomes. The chapters in the fourth section address the emergence of transdiagnostic approaches as exemplified by the Research Domain Criteria initiative and non-invasive brain stimulation techniques. Finally, the book concludes with the late stages of drug development, such as the planning and performance of clinical trials, and regulatory approval. Written by experts from academia and industry, the book covers important fundamentals and best practices as well as current developments in neurotherapeutic research. It offers in-depth insights into the world of drug development and is essential reading for young scientists who are interested in translational research and want to prepare for an academic or industry career in CNS drug discovery.    

Автор: Lo
Название: Vascular Mechanisms in CNS Trauma
ISBN: 1461486890 ISBN-13(EAN): 9781461486893
Издательство: Springer
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Цена: 200260.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Divided into three sections that cover molecular mechanisms, experimental models and methods, and clinical issues, this work on the vascular aspects of brain and spinal cord trauma features contributions from a wide range of research scientists and clinicians.

Автор: Li Di,Edward H. Kerns
Название: Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs
ISBN: 1118788354 ISBN-13(EAN): 9781118788356
Издательство: Wiley
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Цена: 136170.00 T
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Описание: Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant and most challenging areas of drug discovery.

Автор: David Borsook; Lino R. Beccera; Edward Bullmore; R
Название: Imaging in CNS Drug Discovery and Development
ISBN: 1489984747 ISBN-13(EAN): 9781489984746
Издательство: Springer
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Цена: 174130.00 T
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Описание: Distilling the most salient developments in the use of imaging in drug development and disease mapping, this text integrates new imaging technologies and paradigms with molecular medicine and molecular profiling, and considers the relevant ethical issues.

Автор: Schreiber
Название: Modern CNS Drug Discovery
ISBN: 303062353X ISBN-13(EAN): 9783030623531
Издательство: Springer
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Цена: 51230.00 T
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Описание: This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system.

Автор: McArthur, Robert A.
Название: Translational Neuroimaging
ISBN: 0123869455 ISBN-13(EAN): 9780123869456
Издательство: Elsevier Science
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Цена: 148220.00 T
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Описание: Examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. This book provides common endpoints between species that can serve to inform the clinic and bench with the information needed to accelerate clinically-effective CNS drug discovery.

Автор: McArthur, Robert A.
Название: Animal And Translational Models For Cns Drug Discovery: Neurological Disorders
ISBN: 0123738555 ISBN-13(EAN): 9780123738554
Издательство: Elsevier Science
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Цена: 70730.00 T
Наличие на складе: Поставка под заказ.
Описание: Suitable for researchers in academia and pharmaceutical industry who use animal models in research and development of drugs for neurological disorders, this title identifies and provides common endpoints between species that can serve to inform the clinic and the bench with information needed to accelerate clinically-effective CNS drug discovery.

Автор: McArthur, Robert A.
Название: Animal And Translational Models For Cns Drug Discovery: Psychiatric Disorders
ISBN: 0123738563 ISBN-13(EAN): 9780123738561
Издательство: Elsevier Science
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Цена: 79730.00 T
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Описание: Suitable for researchers in academia and pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders, this title identifies and provides common endpoints between species that can serve to inform the clinic and the bench with information needed to accelerate clinically-effective CNS drug discovery.

Автор: McArthur, Robert A.
Название: Animal And Translational Models For Cns Drug Discovery: Reward Deficit Disorders
ISBN: 0123738601 ISBN-13(EAN): 9780123738608
Издательство: Elsevier Science
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Цена: 79730.00 T
Наличие на складе: Поставка под заказ.
Описание: Suitable for researchers in academia and pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders, this title identifies and provides common endpoints between species that can serve to inform the clinic and bench with information needed to accelerate clinically-effective CNS drug discovery.

Название: Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing Cns: Part II, 161
ISBN: 0323992609 ISBN-13(EAN): 9780323992602
Издательство: Elsevier Science
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Цена: 162820.00 T
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Описание: Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS: Part II, Volume 161, in the International Review on Neurobiology serial highlights new advances, with this volume presenting chapters on topics including Introduction to Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS, Peri-adolescent Exposure to (Meth)amphetamine in Animal Models, The Impact of Adolescent Nicotine Exposure on Alcohol Use During Adulthood: The Role of Neuropeptides, Cannabis Exposure During Adolescence: A uniquely Sensitive Period for Neurobiological Effects, The Stoned Age: Sex Differences in the Effects of Adolescent Cannabinoid Exposure on Prefrontal Cortex Structure and Function in Animal Models, and more.

Автор: Rahman, Shafiqur
Название: Effects Of Peri-Adolescent Licit And Illicit Drug Use On The Developing Cns Part I,160
ISBN: 0128208058 ISBN-13(EAN): 9780128208052
Издательство: Elsevier Science
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Цена: 185270.00 T
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Описание: Follow one girl as she builds a rocket and plans to take her friends on an amazing trip to the Sun and Moon. But will the task prove more difficult than she first thought? Imaginatively illustrated by T.S Spookytooth, this clever and inventive poem was written by eleven-year-old Collins Big Cat 2011 Writing Competition winner Nicole Sharrocks.

Автор: Bradbury, Michael
Название: The Blood-Brain Barrier and Drug Delivery to the CNS
ISBN: 0824703944 ISBN-13(EAN): 9780824703943
Издательство: Taylor&Francis
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Цена: 183750.00 T
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Автор: Carl Faingold
Название: Neuronal Networks in Brain Function, CNS Disorders, and Therapeut
ISBN: 0124158048 ISBN-13(EAN): 9780124158047
Издательство: Elsevier Science
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Цена: 116780.00 T
Наличие на складе: Поставка под заказ.
Описание: Offers a review of what we know about neural networks. This book advances the understanding of: how the brain carries out important tasks via networks; how these networks interact in normal brain function; major mechanisms that control network function; and the interaction of the normal networks to produce more complex behaviors.