Автор: Grakoui Arash, Pawlotsky Jean-Michel, Randall Glenn Название: Hepatitis C Virus: The Story of a Scientific and Therapeutic Revolution ISBN: 1621823199 ISBN-13(EAN): 9781621823193 Издательство: Неизвестно Рейтинг: Цена: 44080 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Hepatitis C is a liver disease caused by infection with the hepatitis C virus (HCV), a bloodborne pathogen. In some people, an immune response will clear the infection; however, in most, the infection becomes chronic and treatment with antiviral medication is necessary to prevent serious liver damage and cancer. The eradication of HCV will require improved access to diagnosis and treatment, an enhanced understanding of virus-host interactions, and the development of an effective vaccine. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines all aspects of the biology of HCV, the pathological consequences of infection, the current standard of hepatitis C treatment, and ongoing efforts to control the disease. Contributors discuss the structural and biochemical properties of HCV, the molecular details of its life cycle, and how it promotes liver disease by perturbing host cell signaling pathways. They likewise examine the innate and adaptive immune responses elicited by HCV and why those responses often fail to clear the infection. Direct-acting antiviral regimens to treat infected patients, the impacts of those treatments on hepatitis C epidemiology, and obstacles to HCV elimination (e.g., vaccine development) are also covered. This volume includes additional perspectives on the discovery of HCV, historical milestones in HCV research, and animal and cell culture models of HCV infection. It is an essential reference for virologists, immunologists, and all clinical and laboratory investigators interested in eliminating HCV as a public health threat.
Автор: Yun-Fan Liaw; Fabien Zoulim Название: Hepatitis B Virus in Human Diseases ISBN: 3319363085 ISBN-13(EAN): 9783319363080 Издательство: Springer Рейтинг: Цена: 62520 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for students, clinicians, and researchers with an interest in hepatitis B. The book reviews new data about basic and translational science including the viral life cycle, the immunopathogenesis of virus induced chronic hepatitis, the mechanism of virus induced liver cancer, and their potential applications for the clinical management of patients. The clinical aspects of this chronic viral infection are reviewed in detail with important chapters on the global epidemiology, the natural history of the disease, co-infections with its satellite virus HDV or HIV, and management of special patient populations. A major emphasis is made on the management of antiviral therapy and the recent international guidelines for the treatment of hepatitis B. Finally, the book reviews the current state of the art regarding immunoprophylaxis to prevent the spread of the virus and its major clinical consequences. The new advances and perspectives in the development of improved antiviral treatments are also discussed.Hepatitis B Virus in Human Diseases will serve as a very useful resource for students, physicians and researchers dealing with, and interested in, this challenging chronic viral infection. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information.
Автор: M. Feitelson Название: Molecular Components of Hepatitis B Virus ISBN: 1461296153 ISBN-13(EAN): 9781461296157 Издательство: Springer Рейтинг: Цена: 137470 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Since the discovery of Australia antigen and its association with type B hepatitis, molecular characterization of the components making up hepatitis B virus (RBV) have been pursued with worldwide interest.
Автор: Tang Название: Hepatitis B Virus Infection ISBN: 9811391505 ISBN-13(EAN): 9789811391507 Издательство: Springer Рейтинг: Цена: 102970 T Наличие на складе: Невозможна поставка. Описание: It covers our current understanding of the HBV genome and lifecycle, liver-enriched factors in the regulation of HBV transcription and translation, HBV protein structures and biological functions, and the immunology and pathogenesis of HBV.
Автор: Tatsuo Miyamura; Stanley M. Lemon; Christopher M. Название: Hepatitis C Virus II ISBN: 4431567763 ISBN-13(EAN): 9784431567769 Издательство: Springer Рейтинг: Цена: 125040 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book helps scientists, clinicians and other interested individuals understand recent clinical advances and challenges for the future. It covers many basic aspects of the pathogenesis of chronic hepatitis C, HCV infections in particular populations, approaches to therapy, and prevention and control of HCV Infection. The book provides a succinct review of the large amount of data generated by multiple groups over the past two decades that has revealed the natural history of HCV infection. Similarly, it summarizes current understanding of the origins of HCV-associated hepatocellular carcinoma, cirrhosis and hepatic fibrosis. Extra-hepatic manifestation and metabolic disorders related to HCV infection are described. In this volume, these clinically important aspects of HCV infection are comprehensively described. Highlights are description of newly developed direct- acting antivirals. The authors represent a worldwide distribution of leaders in the field reflecting the global nature of HCV infection. Based on recent data concerning the genetic- and geographical diversity of HCV, and increased global disease burden of HCV infection, challenges for global control of HCV infections are described.
Автор: Tatsuo Miyamura; Stanley M. Lemon; Christopher M. Название: Hepatitis C Virus II ISBN: 4431560998 ISBN-13(EAN): 9784431560999 Издательство: Springer Рейтинг: Цена: 125040 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book helps scientists, clinicians and otherinterested individuals understand recent clinical advances and challenges forthe future. It covers many basic aspects of the pathogenesis of chronic hepatitisC, HCV infections in particular populations, approaches to therapy, andprevention and control of HCV Infection. The book provides a succinct review ofthe large amount of data generated by multiple groups over the past two decadesthat has revealed the natural history of HCV infection. Similarly, itsummarizes current understanding of the origins of HCV-associatedhepatocellular carcinoma, cirrhosis and hepatic fibrosis. Extra-hepaticmanifestation and metabolic disorders related to HCV infection are described.In this volume, these clinically important aspects of HCV infection arecomprehensively described. Highlights are description of newly developed direct- acting antivirals. The authors represent a worldwidedistribution of leaders in the field reflecting the global nature of HCVinfection. Based on recent data concerning the genetic- and geographicaldiversity of HCV, and increased global disease burden of HCV infection, challenges for global control of HCV infections are described.
Автор: Kazuaki Chayama Название: Hepatitis C Virus Treatment ISBN: 9811096104 ISBN-13(EAN): 9789811096105 Издательство: Springer Рейтинг: Цена: 102970 T Наличие на складе: Невозможна поставка. Описание: This book introduces readers to Direct Acting Antiviral (DAAs) agents, newly developed drugs to treat chronic hepatitis C virus infection, which have an excellent anti-viral effect on virus replication.
Автор: Ralf Bartenschlager Название: Hepatitis C Virus: From Molecular Virology to Antiviral Therapy ISBN: 364242936X ISBN-13(EAN): 9783642429361 Издательство: Springer Рейтинг: Цена: 116850 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected.
Автор: Haitao Guo; Andrea Cuconati Название: Hepatitis B Virus ISBN: 1493966987 ISBN-13(EAN): 9781493966981 Издательство: Springer Рейтинг: Цена: 102970 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume serves as a reference for the dissemination of advances made in the study of Hepatitis B Virus (HBV). Hepatitis B Virus: Methods and Protocols details protocols and techniques ranging from cell culture studies to in vivo and clinical immunology. The chapters in this book discuss treatments of in vitro infection systems, analysis and quantification of cccDNA and its mutations; in vitro polymerase activity assays; cellular trafficking of core proteins; intracellular calcium metabolism; detection, cloning, and sequencing of HBV markers; and new strategies aimed at exploiting new mechanisms for drug discovery. The book also covers classical methods for resolution of extracellular viral particles by native gel electrophoresis, and methods for detecting HBV antigens in drug discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and comprehensive, Hepatitis B Virus: Methods and Protocols is a valuable tool for researchers to use toward their advanced studies in HBV.
Автор: Emilio Jirillo Название: Hepatitis C Virus Disease ISBN: 1441924388 ISBN-13(EAN): 9781441924384 Издательство: Springer Рейтинг: Цена: 109980 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Despite numerous hepatitis C virus infection studies, its pathogenesis and medical treatment have not been fully explained. This comprehensive volume, written by experts in the field, covers the most recent advances in the study of HCV, moving from basic research to clinical applications.
Автор: Miyamura Название: Hepatitis C Virus I ISBN: 4431560963 ISBN-13(EAN): 9784431560968 Издательство: Springer Рейтинг: Цена: 125040 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume is composed of chapters that review important fundamental aspects of HCV biology and disease pathogenesis including, for example, the discovery and identification of the HCV genome, early virus-cell interactions including identification of various cellular receptors, HCV gene expression studied using the HCV replicon system, identification and characterization of HCV structural- and non-structural HCV proteins, HCV replication in cultured cells, and host factors involved in viral replication. This volume also contains chapters dealing with immunity to HCV infection and pathogenesis. This is particularly important in understanding hepatitis C because HCV infection alone is not cell lytic. Mechanisms underlying the persistent nature of HCV infection are also discussed in these chapters. Many of the authors published articles that were listed among the “top 10 papers” published in the 24 years since HCV was discovered in 1989. Their citations are above 1,000 (Web of Science). The authors describe the background and significance of their contributions to the field in the context of findings from other research groups.
Автор: Engelbrecht Torsten, Claus Kцhnlein, Samatha Bailey Название: Virus Mania: Corona/COVID-19, Measles, Swine Flu, Cervical Cancer, Avian Flu, SARS, BSE, Hepatitis C, AIDS, Polio, Spanish Flu. How ISBN: 3752629789 ISBN-13(EAN): 9783752629781 Издательство: Неизвестно Рейтинг: Цена: 38630 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: If one follows public pronouncements, the world is repeatedly afflicted with new terrible virus diseases. As the latest horror variant, the so-called coronavirus SARS-CoV-2 dominated the headlines. The population is also terrified by reports of measles, swine flu, SARS, BSE, AIDS or polio. However, the authors of "Virus Mania," investigative journalist Torsten Engelbrecht, Dr. Claus K hnlein, MD, Dr. Samantha Bailey, MD, and Dr. Stefano Scoglio, BSc PhD, show that this fear mongering is unfounded and that virus mayhem ignores basic scientific facts: The existence, the pathogenicity and the deadly effects of these agents have never been proven. The book"Virus Mania will also outline how modern medicine has pushed direct detection methods aside and uses dubious indirect tools to prove the existence of viruses such as antibody tests and the polymerase chain reaction (PCR). The alleged viruses may be, in fact, also be seen as particles produced by the cells themselves as a consequence of certain stress factors such as drugs. These particles are then "picked up" by antibody and PCR tests and mistakenly interpreted as epidemic-causing viruses. The aim of this book is to steer the discussion back to a real scientific debate and put medicine back on the path of an impartial analysis of the facts. Engelbrecht, K hnlein, Bailey and Scoglio will analyze all real causes of the illnesses named COVID-19, avian flu, AIDS or Spanish flu, among them pharmaceuticals, lifestyle drugs, pesticides, heavy metals, pollution, malnutrition and stress. All of these can heavily damage the body of humans and animals and even kill them. To substantiate these claims, the authors cite dozens of highly renowned scientists, among them the Nobel laureates Kary Mullis, Barbara McClintock, Walter Gilbert and Sir Frank Macfarlane Burnet as well as microbiologist and Pulitzer Prize winner Ren Dubos. The book presents more than 1,400 solid scientific references. The topic of "Virus Mania" is of pivo
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