Hepatitis C Virus: The Story of a Scientific and Therapeutic Revolution, Grakoui Arash, Pawlotsky Jean-Michel, Randall Glenn

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines all aspects of the biology of HCV, the pathological consequences of infection, the current standard of hepatitis C treatment, and ongoing efforts to control the disease. Contributors
discuss the structural and biochemical properties of HCV, the molecular details of its life cycle, and how it promotes liver disease by perturbing host cell signaling pathways. They likewise examine the innate and adaptive immune responses elicited by HCV and why those responses often fail to clear
the infection. Direct-acting antiviral regimens to treat infected patients, the impacts of those treatments on hepatitis C epidemiology, and obstacles to HCV elimination (e.g., vaccine development) are also covered.