Bone marrow stem cell therapy for stroke, Kunlin Jin; Xunming Ji; Qichuan Zhuge

Автор: El-Badri
Название: Advances in Stem Cell Therapy
ISBN: 3319291475 ISBN-13(EAN): 9783319291475
Издательство: Springer
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Цена: 139750.00 T
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Описание: The book reviews the main approaches for generation of differentiated cells from various types of stem cells, including embryonic, placental and cord blood stem cells through marrow, adipose tissue and dental pulp. The book starts with an overview of experimental protocols applied to generate insulin secreting cells, neural cells, heart cells, and other tissue specific cells ex vivo and in experimental animals. This is followed by exhaustive review of clinical trials in these pathologies. It continues with a comparison of the merits of successful transplantation in humans versus animal experimentation, and highlights the most promising clinical applications in the field. Special chapters are devoted to the topic of tissue engineering and modern synthetic and biological scaffolds. It is essential reading for scientists and researchers in tissue engineering and stem cell research as well as clinicians who are involved in developing or testing stem cell therapies.

Автор: Indumathi Somasundaram
Название: Stem Cell Therapy for Organ Failure
ISBN: 8132221095 ISBN-13(EAN): 9788132221098
Издательство: Springer
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Цена: 149060.00 T
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Описание: The book “STEM CELL THERAPY FOR ORGAN FAILURES” edited by Dr. S. Indumathi demonstrates the In Vitro and In vivo therapeutic strategies and applications of pre- and post-natal stem cells for treating the failures of various organ systems of our body in a wide perspective. It explores the past, present and the futuristic approach of the exciting field of stem cells and its intriguing properties involved in tissue repair and regeneration. The prime focus of this volume is to unravel the basic, advanced, therapeutic and translational approaches put-forth so far in the field of stem cells and regenerative medicine at research, pre-clinical and clinical levels. Stem cells has ushered in widespread interest and exciting possibilities for cell based therapies, albeit failures do prevail and small uncontrolled phase I/II studies are only signals generating, rather than definite proof of concept thereby limiting its applicability in curative therapeutics. Despite certain initiatives and meticulous untiring efforts, bringing this basic bench side research into advanced transitional bedside remained a challenge. Thus, this book embarked upon the expanding researches in these areas that seem decisive in improvising regenerative medical therapeutics, thereby leading to further path-breaking studies that cure all health challenges facing mankind. Overall, this book reveals the imperativeness of various stem cell sources and its utility in curative therapeutics.

Автор: Jaap Jan Boelens; Robert Wynn
Название: Stem Cell Therapy in Lysosomal Storage Diseases
ISBN: 1493948881 ISBN-13(EAN): 9781493948888
Издательство: Springer
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Цена: 130590.00 T
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Описание: This volume discusses the history, current practice and future perspectives of stem cell in inborn errors of metabolism and provides an international perspective on progress, limitations, and future directions in the field.

Автор: Mohamed Al-Rubeai; Mariam Naciri
Название: Stem Cells and Cell Therapy
ISBN: 9400771959 ISBN-13(EAN): 9789400771956
Издательство: Springer
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Цена: 130610.00 T
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Описание: It includes chapters on neural and vascular stem vascular stem cell therapy, expansion engineering of embryonic stem cells, stem cell based production of blood cells and separation technologies for stem cells and cell therapy products.

Автор: Lucas G. Chase; Mohan C Vemuri
Название: Mesenchymal Stem Cell Therapy
ISBN: 1627039147 ISBN-13(EAN): 9781627039147
Издательство: Springer
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Цена: 144410.00 T
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Описание: Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Автор: Nicole I. Nieden
Название: Embryonic Stem Cell Therapy for Osteo-Degenerative Diseases
ISBN: 1493957236 ISBN-13(EAN): 9781493957231
Издательство: Springer
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Цена: 135090.00 T
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Описание: In this dependable and cutting-edge book, accomplished investigators provide detailed descriptions on how to expand ESCs from the most commonly used species ex vivo, i.e. mouse and human, in static culture as well as in controllable bioreactor processes.

Автор: Boelens Jaap Jan
Название: Stem Cell Therapy in Lysosomal Storage Diseases
ISBN: 1461483565 ISBN-13(EAN): 9781461483564
Издательство: Springer
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Цена: 156720.00 T
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Описание: This volume discusses the history, current practice and future perspectives of stem cell in inborn errors of metabolism and provides an international perspective on progress, limitations, and future directions in the field.

Автор: Meral Beksa?
Название: Bone Marrow and Stem Cell Transplantation
ISBN: 1493944304 ISBN-13(EAN): 9781493944309
Издательство: Springer
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Цена: 102480.00 T
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Описание: The second edition of Bone Marrow and Stem Cell Transplantation expands upon the previous edition with current, detailed methods on HLA, minor-HLA and Killer Immunoglobulin Like Receptor typing.

Автор: Meral Beksa?
Название: Bone Marrow and Stem Cell Transplantation
ISBN: 1461494362 ISBN-13(EAN): 9781461494362
Издательство: Springer
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Цена: 97820.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The second edition of Bone Marrow and Stem Cell Transplantation expands upon the previous edition with current, detailed methods on HLA, minor-HLA and Killer Immunoglobulin Like Receptor typing.

Автор: Price Jack
Название: The Future of Brain Repair: A Realist`s Guide to Stem Cell Therapy
ISBN: 0262043750 ISBN-13(EAN): 9780262043755
Издательство: MIT Press
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Цена: 33800.00 T
Наличие на складе: Невозможна поставка.
Описание: A scientist assesses the potential of stem cell therapies for treating such brain disorders as stroke, Alzheimer's disease, and Parkinson's disease.

Stem cell therapies are the subject of enormous hype, endowed by the media with almost magical qualities and imagined by the public to bring about miracle cures. Stem cells have the potential to generate new cells of different types, and have been shown to do so in certain cases. Could stem cell transplants repair the damaged brain? In this book, neurobiologist Jack Price assesses the potential of stem cell therapies to treat such brain disorders as stroke, Alzheimer's disease, Parkinson's disease, and spinal cord injuries.

Certainly brain disorders are in need of effective treatments. These disorders don't just kill, they disable, and conventional drug therapies have not had much success in treating them. Price explains that repairing the human brain is difficult, largely because of its structural, functional, and developmental complexity. He examines the self-repairing capacity of blood and gut cells--and the lack of such capacity in the brain; describes the limitations of early brain stem cell therapies for neurodegenerative disorders; and discusses current clinical trials that may lead to the first licensed stem cell therapies for stroke, Parkinson's and macular degeneration. And he describes the real promise of pluripotential stem cells, which can make all the cell types that constitute the body.

New technologies, Price reports, challenge the very notion of cell transplantation, instead seeking to convince the brain itself to manufacture the new cells it needs. Could this be the true future of brain repair?

Автор: El-Badri Nagwa
Название: Advances in Stem Cell Therapy: Bench to Bedside
ISBN: 3319805010 ISBN-13(EAN): 9783319805016
Издательство: Springer
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Цена: 93160.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book reviews the main approaches for generation of differentiated cells from various types of stem cells, including embryonic, placental and cord blood stem cells through marrow, adipose tissue and dental pulp.

Автор: Burgess
Название: Stem Cell-Based Therapy for Lung Disease
ISBN: 3030294021 ISBN-13(EAN): 9783030294021
Издательство: Springer
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Цена: 83850.00 T
Наличие на складе: Поставка под заказ.
Описание: This book presents state-of-the-art pre-clinical models and clinical applications of stem-cell-based therapies applied to different lung diseases, with a special focus on the translation of bench data into clinical studies. Starting with the assumption that abnormal lung tissue repair and regeneration has emerged as the driving force underlying pathogenesis and progression in many lung diseases, it sheds new light on the potential of stem/stromal cells as drivers of repair and sources of reparative factors in the lung. The first part of the book offers an overview of stem cell types and mechanisms involved in lung development, homeostasis, repair and regeneration, and reveals the crucial role of the extracellular matrix within the lung microenvironment. In the second part, leading experts present the latest pre-clinical evidence and clinical applications of stem-cell-based therapies in a wide variety of lung diseases, ranging from COPD and lung fibrosis to other rare lung diseases. The last section discusses stem cell delivery systems and devices, such as aerosolised spray application. This book appeals to pneumologists, stem cell and matrix biologists, as well as bioengeneers with a special interest in regenerative medicine applied to pulmonary diseases.