Biochemical Basis and Therapeutic Implications of Angiogenesis, Jawahar L. Mehta; Pankaj Mathur; Naranjan S. Dhall

Название: Tumor Angiogenesis Regulators
ISBN: 1466580976 ISBN-13(EAN): 9781466580978
Издательство: Taylor&Francis
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Описание: The emphasis of this book is on mechanisms and pathways regulating the expression and actions of classical and novel tumor angiogenesis regulators. The contributors discuss their underlying biology as well as anti-angiogenic drugs currently in use to fight different cancers. The book provides an insight on how factors such as obesity, diabetes, and

Автор: Ribatti Domenico
Название: The Role of Microenvironment in the Control of Tumor Angiogenesis
ISBN: 3319802224 ISBN-13(EAN): 9783319802220
Издательство: Springer
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Цена: 93160.00 T
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Описание: This work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis. Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, adhesion molecules and proteolytic enzymes. In normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. Tumor angiogenesis is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors for endothelial cells, that stimulate the growth of the blood vessels of the host or the down-regulation of natural angiogenesis inhibitors. In particular, the inflammatory infiltrate may contribute to tumor angiogenesis, and there are many reports of associations between tumor inflammatory infiltrate, vascularity and prognosis. New therapeutic approaches have been developed with the aim to control tumor angiogenesis through targeting of different components of tumor microenvironment.

Автор: Jawahar L. Mehta; Pankaj Mathur; Naranjan S. Dhall
Название: Biochemical Basis and Therapeutic Implications of Angiogenesis
ISBN: 3319611143 ISBN-13(EAN): 9783319611143
Издательство: Springer
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Цена: 186330.00 T
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Описание: Leading authorities on the biochemistry of this complex physiological process explain its critical role in human growth and development as well as the pathogenesis of cancer, heart disease, and other morbidities. The book fully updates the current literature.

Автор: Figg
Название: Angiogenesis
ISBN: 0387715177 ISBN-13(EAN): 9780387715179
Издательство: Springer
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Описание: Dr Judah Folkman (1933-2008) was considered the `father of angiogenesis`. Because of Folkman`s discovery and research, the possibilities of angiogenic therapy have broadened beyond cancer to many noncancerous diseases. This book presents a summary of tumor angiogenesis.

Автор: Yukihito Higashi; Toyoaki Murohara
Название: Therapeutic Angiogenesis
ISBN: 9811096945 ISBN-13(EAN): 9789811096945
Издательство: Springer
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Цена: 107130.00 T
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Описание: The book discusses these therapies and presents data collected in clinical studies over the past decade. Despite significant advances in therapeutic angiogenesis since the first clinical studies in the early 21st century, it has been largely ignored in the literature.

Автор: J.A. Dormandy; W.P. Dole; G.M. Rubanyi
Название: Therapeutic Angiogenesis
ISBN: 3662037785 ISBN-13(EAN): 9783662037782
Издательство: Springer
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Цена: 46570.00 T
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Описание: Over the past decade, rapid progress had been made in elucidating the cellular and molecular mechanisms of new blood vessel formation in both health and disease.

Автор: Mark Slevin
Название: Therapeutic Angiogenesis for Vascular Diseases
ISBN: 9400789793 ISBN-13(EAN): 9789400789791
Издательство: Springer
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Цена: 204970.00 T
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Описание: Angiogenesis is the growth of new blood vessels and is a key process which occurs during pathological disease progression. Excessive and damaging angiogenesis occurs in diseases such as cancer, diabetic retinopathies, age-related macular degeneration and atherosclerosis. In other diseases such as stroke and myocardial infarction, insufficient or improper angiogenesis results in tissue loss and ultimately higher morbidity and mortality. In this book we will begin by providing the reader with an overview of the process of angiogenesis including normal embryological development of blood vessels. The following chapters will each focus on a key angiogenic disease incorporating current scientific knowledge concerning the causes of activation of the “angiogenic switch”, pathological consequences, current treatment options and future perspectives. Where appropriate, results from pre-clinical trials, novel imaging modalities and nanotechnological approaches will be incorporated into these sections. Finally, since it is now believed that the process of angiogenesis operated via different signalling mechanisms in different vascular beds, we will discuss our current understanding of this phenomenon. The target audience for this book would include researchers in all the basic sciences; post-graduate students at Universities and Institutes; pharmaceutical industries; clinicians working in vascular biology or tissue imaging; pathologists; neurologists; tumour biologists; ophthalmologists and cardiologists.

Автор: Domenico Ribatti
Название: The Role of Microenvironment in the Control of Tumor Angiogenesis
ISBN: 3319278185 ISBN-13(EAN): 9783319278186
Издательство: Springer
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Цена: 121890.00 T
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Описание:

Prelims

1. Tumor microenvironment

1.1. Metastatic cascade

1.2. Epithelial-mesenchymal transition

1.3. The extracellular matrix

2. Tumor blood vessels and tumor endothelial cells

2.1. Tumor basement membrane

Автор: Mousa, Shaker
Название: Anti-Angiogenesis Strategies in Cancer Therapeutics
ISBN: 012802576X ISBN-13(EAN): 9780128025765
Издательство: Elsevier Science
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Описание: Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences.

Автор: Martin Stewart G., Hewett Peter W.
Название: Angiogenesis Protocols
ISBN: 1493980998 ISBN-13(EAN): 9781493980994
Издательство: Springer
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Цена: 124730.00 T
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Описание: Inaddition to updating important core techniques this third edition presents newchapters on assessing leukocyte involvement in angiogenesis, lymphatic cell andpericyte isolation techniques, spheroid and arterial ring based in vitroassays, and on pericyte involvement in angiogenesis.

Автор: J?zef Dulak; Alicja J?zkowicz; Agnieszka ?oboda
Название: Angiogenesis and Vascularisation
ISBN: 3709119685 ISBN-13(EAN): 9783709119686
Издательство: Springer
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Цена: 139310.00 T
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Описание: This book presents the state of the art in vascular biology, investigating cellular and molecular aspects of blood vessel formation and their functioning in health and diseases. It places special emphasis on reactive oxygen species and role of microRNAs.

Автор: Ribatti Domenico
Название: Tumor Angiogenesis Assays: Methods and Protocols
ISBN: 1493981498 ISBN-13(EAN): 9781493981496
Издательство: Springer
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Цена: 88500.00 T
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Описание:

1. The Discovery of Tumor Angiogenesis Factors: An Historical Overview
Domenico Ribatti

2. Morphological Aspects of Tumor Angiogenesis
Rusland Hlushchuk, Sйbastien Barrй, Valentin Djonov

3. Exosomes in Tumor Angiogenesis
Karma Z. Salem, Michele Moschetta, Antonio Sacco, Luisa Imberti, Giuseppe Rossi, Irene M. Ghobrial, Salomon Manier, and Aldo M. Roccaro

4. Co-Culture Assays for Endothelial Cells: Mural Cells Interactions
Diana M. Sбnchez-Palencia, Alex Bigger-Allen, Magali Saint-Geniez, Joseph F. Arboleda-Velбsquez, Patricia A. D'Amore

5. Characterization of Cancer Stem Cells
Stefania Orecchioni and Francesco Bertolini

6. The Aortic Ring Assay and its Use for the Study of Tumor Angiogenesis
Alfred C. Aplin and Roberto F. Nicosia

7. Surface Plasmon Resonance Analysis of Heparin-Binding Angiogenic Growth Factors
Antonella Bugatti and Marco Rusnati

8. An Ex Vivo Tissue Culture Model for Anti-Angiogenic Drug Testing
Mohammad S. Azimi, Michelle Lacey, Debasis Mondal, and Walter L. Murfee

9. The Chorioallantoic Membrane of the Chick Embryo to Assess Tumor Formation and Metastasis
Anne Herrmann, Diana Moss, and Violaine Sйe

10. Transgenic Zebrafish
Xiaowen Chen, Dafne Gays, and Massimo M. Santoro

11. High Resolution Intravital Microscopy of Tumor Angiogenesis
Ann L.B. Seynhaeve and Timo L.M. ten Hagen

12. Subcutaneous Murine Xenograft Models: A Critical Tool for Studying Human Tumor Growth and Angiogenesis In Vivo
Katharina M. Schmidt, Edward K. Geissler, and Sven A. Lang

13. Orthotopic Models of Ovarian Cancer
Alessandra Decio and Raffaella Giavazzi

14. The Rip1Tag2 Transgenic Mouse Model
Ruben Bill and Gerhard Christophori

15. Tumor Blood Vessel Visualization
Clarissa Gillmann and Tobias Bдeuerle

16. Uncovering Metabolic Effects of Anti-Angiogenic Therapy in Tumors by Induced Metabolic Bioluminescence Imaging
Stefano Indraccolo, Stefan Walenta, and Wolfgang Mueller-Klieser

17. Quantitation of Tumor Angiogenesis In Vitro: An All-In-One Angiogenesis Assay
Mahtab Bahramsoltani and Ward De Spiegelaere