Ageing: Lessons from C. Elegans, Olsen Anders, Gill Matthew S.

Автор: Randy F. Stout Jr, Navin Pokala
Название: Neuroglia in C. elegans
ISBN: 1615046887 ISBN-13(EAN): 9781615046881
Издательство: Mare Nostrum (Eurospan)
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Цена: 25040.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The nematode C. elegans is one of the most important model organisms for understanding neurobiology. Its completely mapped neural connectome of 302 neurons and fully characterized and stereotyped development have made it a prototype for understanding nervous system structure, development, and function. Fifty-six out of C. elegans' total of 959 somatic cells are classified as neuroglia. Although research on worm glia has lagged behind studies focused on neurons, there has been a steep upswing in interest during the past decade. Information arising from the recent burst of research on worm glia supports the idea that C. elegans will continue to be an important animal model for understanding glial cell biology. Since the developmental lineage of all cells was mapped, each glial cell in C. elegans is known by a specific name and has research associated with it. We list and describe the glia of the hermaphrodite form of C. elegans and summarize research findings relating to each glial cell. We hope this lecture provides an informative overview of worm glia to accompany the excellent and freely available online resources available to the worm research community.

Автор: Tim Schedl
Название: Germ Cell Development in C. elegans
ISBN: 1489993533 ISBN-13(EAN): 9781489993533
Издательство: Springer
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Цена: 174130.00 T
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Описание: This book examines germ cell development in the model organism Caenorhabditis elegans, discussing the biology, the genetics and the molecular mechanisms for various processes as well as drawing comparisons with other organisms.

Автор: Anders Olsen; Matthew S. Gill
Название: Ageing: Lessons from C. elegans
ISBN: 3319447017 ISBN-13(EAN): 9783319447018
Издательство: Springer
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Цена: 158380.00 T
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Описание: This book brings together in one volume the current state of ageing research in the nematode Caenorhabditis elegans. The authors are leading researchers in the field, placing this topic in the context of human ageing, describing how and why basic discoveries in this simple organism have impacted our prospects for intervention in the ageing process. The authors cover a broad range of topics with regards to organismal and reproductive ageing including anatomical, physiological and biochemical changes, as well as genetic and environmental interventions that promote longevity and ameliorate age-related disease. Ageing is the single most important factor determining the onset of human disease in developed countries. With current worldwide demographic trends indicating that the number of individuals over the age of 65 will continue to rise, it is clear that an understanding of the processes that underpin ageing and age-related disease represents a key challenge in the biomedical sciences. In recent years there have been huge advances in our understanding of the ageing process and many of these have stemmed from genetic analysis of C. elegans. With no analogous book in this subject area this work will be of interest to a wide audience, ranging from academic researchers to the general public.

Автор: Wang, Dayong.
Название: Nanotoxicology in Caenorhabditis elegans
ISBN: 9811302324 ISBN-13(EAN): 9789811302329
Издательство: Springer
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Цена: 149060.00 T
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Описание: This book focuses on the toxicity of engineered nanomaterials (ENMs) and their underlying physicochemical, cellular, physiological, and molecular mechanisms.

Автор: Dayong Wang
Название: Molecular Toxicology in Caenorhabditis elegans
ISBN: 9811336326 ISBN-13(EAN): 9789811336324
Издательство: Springer
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Цена: 158380.00 T
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Описание: This book will focus on the molecular basis of oxidative stress induced by toxicants or stresses and various molecular signalling pathways in regulating the toxicity of toxicants or stresses in Caenorhabditis elegans. It will also cover the discussion on the aspects of response signals, G-protein coupled receptors and ion channels, specific molecular signals, and epigenetic signals involved in the regulation of toxicity from toxicants or stresses. The molecular basis for adaptive response for transgenerational toxicity of environmental toxicants or stresses will be further discussed. Nematode Caenorhabditis elegans is a classic model animal with well-described genetic and developmental backgrounds based on the study of life science, and has been further successfully and widely used in both toxicity assessment and toxicological study of various environmental toxicants or stresses. Based on related available data, this book aims at providing a systematic understanding of the knowledge system of molecular toxicology in C. elegans.

Автор: David Biron; Gal Haspel
Название: C. elegans
ISBN: 149394892X ISBN-13(EAN): 9781493948925
Издательство: Springer
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Цена: 102480.00 T
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Описание: The aim of this volume is to provide a step-by-step guide for implementing a selection of novel techniques in the lab. Each protocol in this volume is presented as a standalone chapter, specifically geared towards addressing practical needs without presuming prior knowledge of the technique at hand. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, C. elegans: Methods and Applications, Second Edition aims to ensure successful results in the further study of this dynamic field.

Автор: Dayong Wang
Название: Exposure Toxicology in Caenorhabditis elegans
ISBN: 9811561281 ISBN-13(EAN): 9789811561283
Издательство: Springer
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Цена: 139750.00 T
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Описание: Also exploring various factors affecting toxicity induction, and exposure to environmental toxicants and stresses, it allows readers to gain a systematic understanding of exposure toxicology in C.

Автор: Dayong Wang
Название: Target Organ Toxicology in Caenorhabditis elegans
ISBN: 981136009X ISBN-13(EAN): 9789811360091
Издательство: Springer
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Цена: 149060.00 T
Наличие на складе: Поставка под заказ.
Описание: This book introduces readers to intestinal and epidermal barriers, and to toxicity induction of environmental toxicants or stresses in the intestine, epidermis, neurons, muscle, and reproductive organs in Caenorhabditis elegans. In addition, it discusses the protective responses of various organs and nematodes’ avoidance behaviour with regard to environmental toxicants or stresses. The intestinal, epidermal, neuronal, and germline signalling pathways required for the regulation of toxicity of environmental toxicants or stresses are also introduced and discussed. As a classic model animal with well-described genetic and developmental backgrounds, the nematode Caenorhabditis elegans has been successfully and widely used in both toxicity assessments and toxicological studies on various environmental toxicants and stresses. Once exposure to certain environmental toxicants has occurred, the toxicants can enter into the primary targeted organs (such as intestinal cells), and even be translocated into secondary targeted organs (such as reproductive organs and neurons). Based on related available data, this book provides a systematic understanding of target organ toxicology in C. elegans.

Автор: Randy F. Stout Jr, Navin Pokala
Название: Neuroglia in C. elegans
ISBN: 1615047735 ISBN-13(EAN): 9781615047734
Издательство: Mare Nostrum (Eurospan)
Рейтинг:
Цена: 41760.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The nematode C. elegans is one of the most important model organisms for understanding neurobiology. Its completely mapped neural connectome of 302 neurons and fully characterized and stereotyped development have made it a prototype for understanding nervous system structure, development, and function. Fifty-six out of C. elegans' total of 959 somatic cells are classified as neuroglia. Although research on worm glia has lagged behind studies focused on neurons, there has been a steep upswing in interest during the past decade. Information arising from the recent burst of research on worm glia supports the idea that C. elegans will continue to be an important animal model for understanding glial cell biology. Since the developmental lineage of all cells was mapped, each glial cell in C. elegans is known by a specific name and has research associated with it. We list and describe the glia of the hermaphrodite form of C. elegans and summarize research findings relating to each glial cell. We hope this lecture provides an informative overview of worm glia to accompany the excellent and freely available online resources available to the worm research community.

Автор: Dayong Wang
Название: Nanotoxicology in Caenorhabditis elegans
ISBN: 9811343659 ISBN-13(EAN): 9789811343650
Издательство: Springer
Рейтинг:
Цена: 149060.00 T
Наличие на складе: Поставка под заказ.
Описание: This book focuses on the toxicity of engineered nanomaterials (ENMs) and their underlying physicochemical, cellular, physiological, and molecular mechanisms. Further, it covers ENMs’ translocation and their targeted organ toxicology, and discusses chemical and pharmacological strategies used to combat nanotoxicity. Engineered nanomaterials (ENMs) are defined as materials with one or more dimensions of less than 100 nm, and have shown considerable promise in several areas of development. At the same time, the potential toxicity of ENMs for human health and environmental organisms is increasingly attracting attention. In addition to the typical properties of model animals, Caenorhabditis elegans is extremely sensitive to environmental toxicants, which makes it the ideal in vivo assay system for toxicological studies. C. elegans has been widely used in toxicity assessment and toxicological studies of environmental toxicants and stresses. This book provides a comprehensive summary of nanotoxicology research on C. elegans.