Nanotoxicology in Caenorhabditis elegans, Dayong Wang
Автор: Dayong Wang Название: Target Organ Toxicology in Caenorhabditis elegans ISBN: 981136009X ISBN-13(EAN): 9789811360091 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Поставка под заказ. Описание: This book introduces readers to intestinal and epidermal barriers, and to toxicity induction of environmental toxicants or stresses in the intestine, epidermis, neurons, muscle, and reproductive organs in Caenorhabditis elegans. In addition, it discusses the protective responses of various organs and nematodes’ avoidance behaviour with regard to environmental toxicants or stresses. The intestinal, epidermal, neuronal, and germline signalling pathways required for the regulation of toxicity of environmental toxicants or stresses are also introduced and discussed. As a classic model animal with well-described genetic and developmental backgrounds, the nematode Caenorhabditis elegans has been successfully and widely used in both toxicity assessments and toxicological studies on various environmental toxicants and stresses. Once exposure to certain environmental toxicants has occurred, the toxicants can enter into the primary targeted organs (such as intestinal cells), and even be translocated into secondary targeted organs (such as reproductive organs and neurons). Based on related available data, this book provides a systematic understanding of target organ toxicology in C. elegans.
Автор: Duran Nelson Название: Nanotoxicology ISBN: 146148992X ISBN-13(EAN): 9781461489924 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book begins with a detailed introduction to engineered nanostructures, followed by a section on methodologies used in research on cytotoxicity and genotoxicity, and concluding with evidence for the cyto- and genotoxicity of specific nanoparticles.
Автор: Nelson Dur?n; Silvia S. Guterres; Oswaldo L. Alves Название: Nanotoxicology ISBN: 1493947931 ISBN-13(EAN): 9781493947935 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book takes a systematic approach to nanotoxicology and the developing risk factors associated with nanosized particles during manufacture and use of nanotechnology. Beginning with a detailed introduction to engineered nanostructures, the first part of the book presents concepts and definitions of nanomaterials from quantum dots to graphene to fullerenes, with detailed discussion of functionalization, stability, and medical and biological applications. The second part critically examines methodologies used to assess cytotoxicity and genotoxicity. Coverage includes interactions with blood (erythrocytes), combinatorial and microarray techniques, cellular mechanisms, and ecotoxicology assessments. Part three describes cases studies both in vitro and in vivo for specific nanomaterials including solid lipid nanoparticles and nanostructured lipid carriers and metallic nanoparticles and metallic oxides. New information is also presented on toxicological aspects of poloxamers and polymeric nanoparticles as drug carriers as well as size effects on cytotoxicity and genotoxicity. Didactic aspects are emphasized in all chapters, making the book suitable for a broad audience ranging from advanced undergraduate and graduate students to researchers in academia and industry. In all, Nanotoxicology: Materials, Methodologies, and Assessments will provide comprehensive insight into biological and environmental interactions with nanostructures. * Provides an introduction to nanostructures actually in use * Describes cyto- and genotoxicity methodologies, and assesses their performance in comparison to common toxicity assays * Discusses the relation of cytotoxicity and genotoxicity to ecotoxicity * Presents a range of applications, from biogenic silver nanoparticles to poloxamers as drug-delivery systems, reflecting the expanding applications of nanotechnology
Автор: Philippe Houdy; Marcel Lahmani; Francelyne Marano Название: Nanoethics and Nanotoxicology ISBN: 3662520311 ISBN-13(EAN): 9783662520314 Издательство: Springer Рейтинг: Цена: 130590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Surveying the state of the art in experimental toxicology relating to nanoparticles and their environmental impact, this volume addresses some burning questions in nanobiotechnology and also discusses vital issues related to ethics and risk assessment.
Автор: Eliana Maria Barbosa Souto, Maria C. Teixeira Название: Nanotoxicology and Nanosafety: Fundamentals on Nanomaterials Toxicological Assessment ISBN: 3110616424 ISBN-13(EAN): 9783110616422 Издательство: Walter de Gruyter Цена: 96630.00 T Наличие на складе: Нет в наличии. Описание: This book addresses nanomaterials toxicological assessment by various methods including in vitro, in vivo and predictive toxicology. An open and generalized approach to the fundamentals on the topics covered provides technical guidance that can be applied to the safety assessment to all potential uses of nanomaterials in the most variate fields, e.g. pharmaceutical, food and technological industries.
Автор: Wang, Dayong. Название: Nanotoxicology in Caenorhabditis elegans ISBN: 9811302324 ISBN-13(EAN): 9789811302329 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Поставка под заказ. Описание: This book focuses on the toxicity of engineered nanomaterials (ENMs) and their underlying physicochemical, cellular, physiological, and molecular mechanisms.
Название: Nanotoxicology, Toxicity Evaluation ISBN: 1498799418 ISBN-13(EAN): 9781498799416 Издательство: Taylor&Francis Рейтинг: Цена: 224570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
As the application of nanotechnology in the myriad disciplines of science and engineering--from agriculture, pharmaceuticals, material science, and biotechnology to sensors, electronics, and mechanical and electrical engineering--brings benefits it also can produce serious threats to human health and the environment that must be evaluated.
The unique properties of nanomaterials make them different from their bulk counterparts. In addition to such unique properties, the nanometric size of nanomaterials can invite some detrimental effects on the health and well-being of living organisms and the environment. Thus, it is important to distinguish nanomaterials with such ill effects from nanomaterials with no or minimum toxicity.
Nanotoxicology: Toxicity Evaluation, Risk Assessment and Management covers issues such as the basic principles of nanotoxicity, methods used for nanotoxicity evaluation, risk assessment and its management for nanomaterial toxicity with a focus on current trends, limitations, challenges, and future directions of nanotoxicity evaluation.
Various experts from different countries discuss these issues in detail in this book. This will be helpful to researchers, educators, and students who are interested in research opportunities for avoiding the environmental and health hazards of nanomaterials. This book will also be useful for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, drugs, and other regulatory sciences.
Автор: Randy F. Stout Jr, Navin Pokala Название: Neuroglia in C. elegans ISBN: 1615046887 ISBN-13(EAN): 9781615046881 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 25040.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The nematode C. elegans is one of the most important model organisms for understanding neurobiology. Its completely mapped neural connectome of 302 neurons and fully characterized and stereotyped development have made it a prototype for understanding nervous system structure, development, and function. Fifty-six out of C. elegans' total of 959 somatic cells are classified as neuroglia. Although research on worm glia has lagged behind studies focused on neurons, there has been a steep upswing in interest during the past decade. Information arising from the recent burst of research on worm glia supports the idea that C. elegans will continue to be an important animal model for understanding glial cell biology. Since the developmental lineage of all cells was mapped, each glial cell in C. elegans is known by a specific name and has research associated with it. We list and describe the glia of the hermaphrodite form of C. elegans and summarize research findings relating to each glial cell. We hope this lecture provides an informative overview of worm glia to accompany the excellent and freely available online resources available to the worm research community.
Автор: Randy F. Stout Jr, Navin Pokala Название: Neuroglia in C. elegans ISBN: 1615047735 ISBN-13(EAN): 9781615047734 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 41760.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The nematode C. elegans is one of the most important model organisms for understanding neurobiology. Its completely mapped neural connectome of 302 neurons and fully characterized and stereotyped development have made it a prototype for understanding nervous system structure, development, and function. Fifty-six out of C. elegans' total of 959 somatic cells are classified as neuroglia. Although research on worm glia has lagged behind studies focused on neurons, there has been a steep upswing in interest during the past decade. Information arising from the recent burst of research on worm glia supports the idea that C. elegans will continue to be an important animal model for understanding glial cell biology. Since the developmental lineage of all cells was mapped, each glial cell in C. elegans is known by a specific name and has research associated with it. We list and describe the glia of the hermaphrodite form of C. elegans and summarize research findings relating to each glial cell. We hope this lecture provides an informative overview of worm glia to accompany the excellent and freely available online resources available to the worm research community.
Автор: Daiana Silva de Avila Название: Caenorhabditis elegans An Overview and Emerging Roles in Studying Disease ISBN: 1536149462 ISBN-13(EAN): 9781536149463 Издательство: Nova Science Рейтинг: Цена: 182680.00 T Наличие на складе: Невозможна поставка. Описание: Caenorhabditis elegans An Overview and Emerging Roles in Studying Disease explores different disease models that have been successfully validated in this nematode, either to unravel disease mechanisms or to perform drug screenings. This nonpathogenic organism has helped to firstly identify genetic mechanisms important in cancer (Ras and Bcl oncogene signaling), aging (insulin signaling), and nervous system development (UNC-6/Netrin signaling). Human conditions such as aging/frailty (Chapter One), metabolic syndrome (Chapter Two), neurodegenerative diseases (Chapters Three and Four) and neurodegeneration induced by chemicals (Chapters Three and Five) are recapitulated in C. elegans. The construction of transgenic animals that mimic the diseases, the advances in understanding molecularly these conditions, potential new treatments and limitations of the models are reviewed in these chapters. Notably, the authors that contributed to this book are from different parts of the world due to the widespread use of this nematode in research.
Автор: Dayong Wang Название: Molecular Toxicology in Caenorhabditis elegans ISBN: 9811336326 ISBN-13(EAN): 9789811336324 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Поставка под заказ. Описание: This book will focus on the molecular basis of oxidative stress induced by toxicants or stresses and various molecular signalling pathways in regulating the toxicity of toxicants or stresses in Caenorhabditis elegans. It will also cover the discussion on the aspects of response signals, G-protein coupled receptors and ion channels, specific molecular signals, and epigenetic signals involved in the regulation of toxicity from toxicants or stresses. The molecular basis for adaptive response for transgenerational toxicity of environmental toxicants or stresses will be further discussed. Nematode Caenorhabditis elegans is a classic model animal with well-described genetic and developmental backgrounds based on the study of life science, and has been further successfully and widely used in both toxicity assessment and toxicological study of various environmental toxicants or stresses. Based on related available data, this book aims at providing a systematic understanding of the knowledge system of molecular toxicology in C. elegans.
Название: Nanotoxicology: Experimental and Computational Perspectives ISBN: 178262158X ISBN-13(EAN): 9781782621584 Издательство: Royal Society of Chemistry Рейтинг: Цена: 223870.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book fills the significant nanotoxicology and nanosafety knowledge gaps and covers a broad range of topics. It targets postgraduates, academics, and practicing industrialists.
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