Mittal Sandeep Targeting the Broadly Pathogenic Kynurenine Pathway 9783319363219

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Автор: Mittal Sandeep
Название: Targeting the Broadly Pathogenic Kynurenine Pathway
ISBN: 9783319363219
Издательство: Springer
Классификация:

Медицинские исследования

Неврология и клиническая нейрофизиология

Белки

Энзимология

Клеточная биология (цитология)

ISBN-10: 3319363212
Обложка/Формат: Paperback
Страницы: 430
Вес: 0.62 кг.
Дата издания: 23.08.2016
Язык: English
Издание: Softcover reprint of
Иллюстрации: 15 tables, black and white; xv, 430 p.; 15 tables, black and white; xv, 430 p.
Размер: 23.39 x 15.60 x 2.31 cm
Читательская аудитория: General (us: trade)
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway and various disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan metabolism. The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host of tissues in response to immune activation). Targeting the enzymes IDO and TDO, as well as other downstream effectors would therefore be likely to generate novel treatment options that would be helpful in a wide variety of clinical settings. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It will explore the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.
Дополнительное описание: Part I. Overview.- Overview of the Kynurenine Pathway of Tryptophan Metabolism.- Role of Tryptophan Metabolism in Health and Disease.- Nutritional Aspects of Tryptophan Metabolism.- Role of Kynurenine Pathway in Early Brain Development.- Role of Kynurenin

Targeting the Broadly Pathogenic Kynurenine Pathway, Mittal Sandeep