Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye, Singh Amit, Kango-Singh Madhuri

Автор: Amit Singh; Madhuri Kango-Singh
Название: Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye
ISBN: 1493953036 ISBN-13(EAN): 9781493953035
Издательство: Springer
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Цена: 139310.00 T
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Описание: This book will discuss molecular genetic mechanisms of pattern formation, mutations in axial patterning, Genetic regulation of growth in Drosophila eye, and more.

Автор: J.S.F. Barker; William T. Starmer; Ross J. MacInty
Название: Ecological and Evolutionary Genetics of Drosophila
ISBN: 1468487701 ISBN-13(EAN): 9781468487701
Издательство: Springer
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Цена: 113190.00 T
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Описание: Proceedings of an international workshop held in Armidale, Australia, January 5-10, 1989

Автор: Seppo Lakovaara
Название: Advances in Genetics, Development, and Evolution of Drosophila
ISBN: 1461583233 ISBN-13(EAN): 9781461583233
Издательство: Springer
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Цена: 113190.00 T
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Описание: This article, 55 pages long and published in the Proceedings of the Amer- ican Academy, described experiments performed with Drosophila ampe- lophila Lov, "a small dipterous insect known under various popular names such as the little fruit fly, pomace fly, vinegar fly, wine fly, and pickled fruit fly."

Автор: J.Richard Hinchliffe; Juan M. Hurle; Dennis Summer
Название: Developmental Patterning of the Vertebrate Limb
ISBN: 1461364574 ISBN-13(EAN): 9781461364573
Издательство: Springer
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Цена: 46570.00 T
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Описание: Proceedings of a NATO ARW held in Santander, Spain, September 23-26, 1990.

Автор: Kevin Moses
Название: Drosophila Eye Development
ISBN: 3642536409 ISBN-13(EAN): 9783642536403
Издательство: Springer
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Цена: 93160.00 T
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Описание: The vertical line shown was not the anterior edge of the eye, but the anterior edge of a moving wave of patterning and cell type specification that 112 years later (1976) Ready, Hansen and Benzer would name the "morphogenetic furrow".

Автор: Pierre Capy; Patricia Gibert; Ian Boussy
Название: Drosophila melanogaster, Drosophila simulans: So Similar, So Different
ISBN: 9401037558 ISBN-13(EAN): 9789401037556
Издательство: Springer
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Цена: 139750.00 T
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Описание: Comparison of closely related species is a powerful D. melanogaster. In D. melanogaster, microsatel- approach to understanding the changes that have oc- lites reveal that West African popUlations are more curred since their divergence from a common ancestor. closely related to non-African populations than to The sibling species Drosophila melanogaster and D. East African popUlations. East African populations are simulans are probably the species pair for which the more variable than West African or non-African popu- most genetic data are available. A workshop held at lations, suggesting that East African populations may 1 Gif/Yvette in January 2002 reviewed and discussed more closely reflect African ancestral variability. comparisons between these species, from their ecol- Ecophysiology, popUlation dynamics and popula- tion structure are also important to understanding the ogy and biogeography to their behavior and DNA evolution of the two species. Genetic diversity (8) polymorphism. is higher in D. simulans (S. Mousset and R. Singh).

Автор: Yamaguchi
Название: Drosophila Models for Human Diseases
ISBN: 9811305285 ISBN-13(EAN): 9789811305283
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Цена: 167700.00 T
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Описание: Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila’s value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.

Автор: Bassem A. Hassan
Название: The Making and Un-Making of Neuronal Circuits in Drosophila
ISBN: 1493962396 ISBN-13(EAN): 9781493962396
Издательство: Springer
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Цена: 121110.00 T
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Описание: Organized in sections on Physiology and Behavior, this Neuromethods series volume explores ideas and concepts behind the methods, tools, and tricks currently being utilized to decode the secrets of the brain of the small fruit fly, drosophila melanogaster.

Автор: Dahmann Christian
Название: Drosophila: Methods and Protocols
ISBN: 149398179X ISBN-13(EAN): 9781493981793
Издательство: Springer
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Цена: 102480.00 T
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Описание: This second edition volume expands on the previous edition by presenting updated protocols for several of the techniques described in the first edition of Drosophila: Methods and Protocols and current methods that cover recent breakthroughs in Drosophila research. The book begins with a description of FlyBase--a database of genes and genomes--followed by the presentation of systems for versatile gene expression in the fly. The first few chapters in this book detail gene knockdown and editing, including CRISPR-Cas9 and protein knockdown. The next few chapters are devoted to methods describing live imaging of different tissues and organs, followed by chapters on how to quantify image data and how to probe tissue mechanics by laser ablation. The next two chapters provide methods for analyzing transcription followed by protocols to study growth, metabolism, ageing, and behavior in Drosophila. This volume concludes with chapters on electrophysiological recordings and methods to establish cell lines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Drosophila: Methods and Protocols, Second Edition is a valuable source of hands-on protocols and reviews for molecular, cell, and developmental biologists using Drosophila as model systems in their work.

Автор: Mousumi Mutsuddi; Ashim Mukherjee
Название: Insights into Human Neurodegeneration: Lessons Learnt from Drosophila
ISBN: 9811322171 ISBN-13(EAN): 9789811322174
Издательство: Springer
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Цена: 139750.00 T
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Описание: This book is aimed at generating an updated reservoir of scientific endeavors undertaken to unravel the complicated yet intriguing topic of neurodegeneration. Scientists from Europe, USA and India who are experts in the field of neurodegenerative diseases have contributed to this book. This book will help readers gain insight into the recent knowledge obtained from Drosophila model, in understanding the molecular mechanisms underlying neurodegenerative disorders and also unravel novel scopes for therapeutic interventions. Different methodologies available to create humanized fly models that faithfully reflects the pathogenicities associated with particular disorders have been described here. It also includes information on the exciting area of neural stem cells. A brief discussion on neurofibrillary tangles, precedes the elaborate description of lessons learnt from Drosophila about Alzheimer's, Parkinson’s, Spinomuscular Atrophy, Huntington’s diseases, RNA expansion disorders and Hereditary Spastic Paraplegia. We have concluded the book with the use of Drosophila for identifying pharmacological therapies for neurodegenerative disorders. The wide range of topics covered here will not only be relevant for beginners who are new to the concept of the extensive utility of Drosophila as a model to study human disorders; but will also be an important contribution to the scientific community, with an insight into the paradigm shift in our understanding of neurodegenerative disorders. Completed with informative tables and communicative illustrations this book will keep the readers glued and intrigued. We have comprehensively anthologized the lessons learnt on neurodegeneration from Drosophila and have thus provided an insight into the multidimensional aspects of pathogenicities of majority of the neurodegenerative disorders.

Автор: Monalisa Mishra
Название: Fundamental Approaches to Screen Abnormalities in Drosophila
ISBN: 1493997556 ISBN-13(EAN): 9781493997558
Издательство: Springer
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Цена: 102480.00 T
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Описание: This volume includes in-depth, hands-on protocols for detecting various developmental defects in Drosophila. It provides cutting-edge methods for maintaining Drosophila under laboratory conditions to perform various experiments, and for dissecting various imaginal discs of the larvae. Further, biochemical protocols for estimating the levels of different metabolites, reactive oxygen species, and fat-sensitive pathways are discussed, and various staining and behavior techniques for fat detection are provided. The book explains how various fluorescent dyes and the comet assay can be used to identify DNA damage, and elaborates on the analysis of the eye, antennae, imaginal disc, gut and muscle damage under bright field and fluorescent microscopes. It covers the analysis of hemolymph using Giemsa staining; determining the functionality of channel proteins, eye and mechanosensory organs in adults and larvae using various behavioral assays; and metal detection and structural analysis for various tissues using SEM. In closing, it addresses the analysis of Drosophila’s eye and head via paraffin section; measurement of reactive oxygen species from various tissues via FACS; and the CRISPER technique for gene editing and analysis of micro RNA mutations.

Автор: Dahmann
Название: Drosophila
ISBN: 1493963694 ISBN-13(EAN): 9781493963690
Издательство: Springer
Рейтинг:
Цена: 102480.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This second edition volume expands on the previous edition by presenting updated protocols for several of the techniques described in the first edition of Drosophila: Methods and Protocols and current methods that cover recent breakthroughs in Drosophila research. The book begins with a description of FlyBase--a database of genes and genomes--followed by the presentation of systems for versatile gene expression in the fly. The first few chapters in this book detail gene knockdown and editing, including CRISPR-Cas9 and protein knockdown. The next few chapters are devoted to methods describing live imaging of different tissues and organs, followed by chapters on how to quantify image data and how to probe tissue mechanics by laser ablation. The next two chapters provide methods for analyzing transcription followed by protocols to study growth, metabolism, ageing, and behavior in Drosophila. This volume concludes with chapters on electrophysiological recordings and methods to establish cell lines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Drosophila: Methods and Protocols, Second Edition is a valuable source of hands-on protocols and reviews for molecular, cell, and developmental biologists using Drosophila as model systems in their work.