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Insights into Human Neurodegeneration: Lessons Learnt from Drosophila, Mousumi Mutsuddi; Ashim Mukherjee


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Автор: Mousumi Mutsuddi; Ashim Mukherjee
Название:  Insights into Human Neurodegeneration: Lessons Learnt from Drosophila
ISBN: 9789811322174
Издательство: Springer
Классификация:




ISBN-10: 9811322171
Обложка/Формат: Hardcover
Страницы: 467
Вес: 1.09 кг.
Дата издания: 2019
Язык: English
Издание: 1st ed. 2019
Иллюстрации: 30 illustrations, color; 30 illustrations, black and white; approx. 350 p. 60 illus., 30 illus. in color.
Размер: 160 x 242 x 30
Читательская аудитория: Professional & vocational
Основная тема: Biomedicine
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This book is aimed at generating an updated reservoir of scientific endeavors undertaken to unravel the complicated yet intriguing topic of neurodegeneration. Scientists from Europe, USA and India who are experts in the field of neurodegenerative diseases have contributed to this book. This book will help readers gain insight into the recent knowledge obtained from Drosophila model, in understanding the molecular mechanisms underlying neurodegenerative disorders and also unravel novel scopes for therapeutic interventions. Different methodologies available to create humanized fly models that faithfully reflects the pathogenicities associated with particular disorders have been described here. It also includes information on the exciting area of neural stem cells. A brief discussion on neurofibrillary tangles, precedes the elaborate description of lessons learnt from Drosophila about Alzheimers, Parkinson’s, Spinomuscular Atrophy, Huntington’s diseases, RNA expansion disorders and Hereditary Spastic Paraplegia. We have concluded the book with the use of Drosophila for identifying pharmacological therapies for neurodegenerative disorders. The wide range of topics covered here will not only be relevant for beginners who are new to the concept of the extensive utility of Drosophila as a model to study human disorders; but will also be an important contribution to the scientific community, with an insight into the paradigm shift in our understanding of neurodegenerative disorders. Completed with informative tables and communicative illustrations this book will keep the readers glued and intrigued. We have comprehensively anthologized the lessons learnt on neurodegeneration from Drosophila and have thus provided an insight into the multidimensional aspects of pathogenicities of majority of the neurodegenerative disorders.
Дополнительное описание: Chapter 1. Introduction to Drosophila as a model organism.- Chapter 2. Methods for creating fly models in order to understand molecular mechanism of neurological diseases.- Chapter 3. Neurodegeneration: Lessons learnt from forward genetic screens in Droso


The Proteasome in Neurodegeneration

Автор: Leonidas Stefanis; J. N. Keller
Название: The Proteasome in Neurodegeneration
ISBN: 1489973451 ISBN-13(EAN): 9781489973450
Издательство: Springer
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Цена: 163040.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: One major factor that has been relatively obscure until recently has been the contribution of protein degradation to the regulation of the steady state level of protein expression and protein function.

Neurodegeneration and Prion Disease

Автор: David R. Brown
Название: Neurodegeneration and Prion Disease
ISBN: 148998688X ISBN-13(EAN): 9781489986887
Издательство: Springer
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Цена: 139310.00 T
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Описание: This is the first and only book on the subject of prions to cover the cause of cell death in the disease. It covers the full range of competing theories on the subject, from broad description and basic points up to the final details of the basic science.

Small Fiber Neuropathy and Related Syndromes: Pain and Neurodegeneration

Автор: Hsieh
Название: Small Fiber Neuropathy and Related Syndromes: Pain and Neurodegeneration
ISBN: 9811335451 ISBN-13(EAN): 9789811335457
Издательство: Springer
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Цена: 121110.00 T
Наличие на складе: Поставка под заказ.
Описание: In addition to describing these conditions which lead to SFN, this book also describes related syndromes of neurodegeneration and pain, including fibromyalgia, visceral pain and hypersensitivity.This definitive book covers both clinical aspects and research progress, which provides in-depth and up-to-date information on SFN.

Neurodegeneration Methods and Protocols

Автор: Jean Harry; Hugh A. Tilson
Название: Neurodegeneration Methods and Protocols
ISBN: 1617370983 ISBN-13(EAN): 9781617370984
Издательство: Springer
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Цена: 135090.00 T
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Описание: Rapid advances in our understanding of basic cell biological processes and of the molecular mechanisms of cell function and dysfunction have led to an increasing interest in utilizing these approaches in neurobiological research.

Neuroinflammation and Neurodegeneration

Автор: Phillip K. Peterson; Michal Toborek
Название: Neuroinflammation and Neurodegeneration
ISBN: 1493946986 ISBN-13(EAN): 9781493946983
Издательство: Springer
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Цена: 148010.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration).

Fundamentals of neurodegeneration and protein misfolding disorders

Автор: Beckerman, Martin
Название: Fundamentals of neurodegeneration and protein misfolding disorders
ISBN: 3319221167 ISBN-13(EAN): 9783319221168
Издательство: Springer
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Цена: 111790.00 T
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Описание: This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer’s disease and Parkinson’s disease to Huntington’s disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today’s forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.

Neuroinflammation and Neurodegeneration

Название: Neuroinflammation and Neurodegeneration
ISBN: 1493910701 ISBN-13(EAN): 9781493910700
Издательство: Springer
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Цена: 186330.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

Mitochondrial Dynamics and Neurodegeneration

Автор: Bingwei Lu
Название: Mitochondrial Dynamics and Neurodegeneration
ISBN: 9400799470 ISBN-13(EAN): 9789400799479
Издательство: Springer
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Цена: 174130.00 T
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Описание: Written by experts, this book offers comprehensive coverage of the mechanisms of mitochondrial dynamics, from basic research on its molecular basis to medical implications, to the direction of future research. Includes numerous color figures and illustrations.

Neurodegeneration: Metallostasis and Proteostasis

Автор: Milardi Danilo
Название: Neurodegeneration: Metallostasis and Proteostasis
ISBN: 1849730504 ISBN-13(EAN): 9781849730501
Издательство: Royal Society of Chemistry
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Цена: 171760.00 T
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Описание: This exemplary book gives an up-to-date perspective on the role of metal ions in neurodegeneration.

Neurodegeneration

Автор: Giovanni Manfredi; Hibiki Kawamata
Название: Neurodegeneration
ISBN: 1493962205 ISBN-13(EAN): 9781493962204
Издательство: Springer
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Цена: 135090.00 T
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Описание: Neurodegeneration tackles the challenges involved with neurodegenerative disorders, such as Alzheimer`s and Parkinson`s disease. The text presents cutting-edge analytical and technological approaches to study the mechanisms underlying neurodegenerative processes.


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