Автор: Domenico Ribatti Название: The Role of Microenvironment in the Control of Tumor Angiogenesis ISBN: 3319278185 ISBN-13(EAN): 9783319278186 Издательство: Springer Рейтинг: Цена: 121890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Prelims
1. Tumor microenvironment
1.1. Metastatic cascade
1.2. Epithelial-mesenchymal transition
1.3. The extracellular matrix
2. Tumor blood vessels and tumor endothelial cells
2.1. Tumor basement membrane
2.2. Tumor pericytes
3. Tumor angiogenesis
3.1. Sprouting angiogenesis
3.2. Vascular co-option
3.3. Vasculogenic mimicry
3.4. Intussusceptive microvascular growth
4. Inflammatory cells in tumor microenvironment
4.1. Neutrophils
4.2. Eosinophils and dendritic cells
4.3. Lymphocytes and platelets
4.4. Mast cells
4.5. Macrophages
4.6. Tie-2 expressing monocytes (TEMs)
4.7. Fibroblasts
4.8. Osteoblasts and osteoclasts
4.9. Cancer stem cells (CSCs)
4.10.Circulating endothelial cells and endothelial precursor cells
5. Therapeutic strategies, the concept of "normalization" and the role of VEGF inhibition
Index
Автор: Rebecca G. Bagley Название: The Tumor Microenvironment ISBN: 146142660X ISBN-13(EAN): 9781461426608 Издательство: Springer Рейтинг: Цена: 243800.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book explores the many biological and physical aspects of the tumor microenvironment. It represents a superb compilation of the latest thoughts and data on this topic, and the in-depth chapters are written by known professionals in the field.
Автор: Yefenof Название: Innate and Adaptive Immunity in the Tumor Microenvironment ISBN: 9048177138 ISBN-13(EAN): 9789048177134 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host.
Автор: Ursini-Siegel Название: The Tumor Microenvironment ISBN: 1493937995 ISBN-13(EAN): 9781493937998 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book covers core and emerging in vitro and in vivo protocols used to study how various components of the tumor microenvironment are established and subsequently interact with tumor cells to facilitate carcinogenesis. In addition, the book examines research topics including cellular and molecular biology approaches, in vivo genetic approaches, various “omics”-based strategies, therapeutic strategies to target the microenvironment, and, finally, advanced techniques in the fields of tissue engineering and nanotechnology. Written and validated in the laboratories of a number of trusted collaborating authors for the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Practical and authoritative, The Tumor Microenvironment: Methods and Protocols constitutes a compendium of techniques now available to a broad audience, including basic and clinician scientists, systems biologists, and biological engineers.
Автор: G. Klaus Название: Microenvironments in the Lymphoid System ISBN: 1461294959 ISBN-13(EAN): 9781461294955 Издательство: Springer Рейтинг: Цена: 139310.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Since 1966, at ro ghly three-yearly intervals, an internation- al group of immunologists has met somewhere in Europe to discuss the latest developments in our understanding of the mechanisms governing the functioning of the immune system in vivo. These meetings have become known as the International C, mferences on Lymphatic Tissues and Germinal Centers in Immune Reactions, or for the regular devotees, simply as the Germinal Cent' r Conferences (GCC). This volume represents the proceedings of the 8th GCC, which was held in Babraham, near Cambridge, UK, between the 14th and 17th August, 1984. When one considers how cellular immunology has become increas- ingly dominated by in vitro methodology over the past twenty years, it may seem remarkable that these conferences-hav survived at all, let alone prospered. However, I for one do not find this surprising, since I suspect that the exquisitely: omplex architect- ure and microenvironments of the lymphoid system will never be fully understood through in vitro studies. If "tae proper study of mankind is an", then surely ultimately the proper study of all the interacting elements which comprise the immune system has to be in vivo. This belief is shared by a substantial number of immunol- ogists, as the contents of this volume will attest. Although the GCC were originally devoted to unravelling the mysteries of the germinal center response (and these are still not fully resolved), over the years the scope of the meetings has inevitably broadened.
Автор: Greenspan Название: Differential diagnosis of tumors and tumor-like lesions of bones and joints ISBN: 0397517106 ISBN-13(EAN): 9780397517107 Издательство: Lippincott Williams & Wilkins Цена: 154440.00 T Наличие на складе: Поставка под заказ. Описание: This volume is a comprehensive guide to the radiologic and pathologic diagnosis of bone tumors. Emphasis is placed on correlation of clinical information, radiologic findings, and pathologic material as a key step in the differential diagnosis and final diagnosis. The book describes and illustrates the radiographic and microscopic appearances of various benign and malignant lesions and explains how the radiologist and the pathologist approach the differential diagnosis. Close attention is given to common sources of error in radiologic interpretation, as well as to cases where the radiologic differential diagnosis varies from the histopathologic differential diagnosis.
Автор: A. Mark Davies; Murali Sundaram; Steven L.J. James Название: Imaging bone tumors and tumor-like lesions ISBN: 3540779825 ISBN-13(EAN): 9783540779827 Издательство: Springer Рейтинг: Цена: 269260.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A comprehensive textbook that provides a description of the imaging techniques and findings in patients with benign and malignant bone tumors. It discusses the techniques and procedures employed for imaging bone tumors. It reviews the role of these imaging techniques in diagnosis, surgical staging, biopsy, and assessment of response to therapy.
Автор: Koumenis Название: Tumor Microenvironment ISBN: 3319266640 ISBN-13(EAN): 9783319266640 Издательство: Springer Рейтинг: Цена: 174150.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume covers the topics presented at the 3rd International Conference on Tumor Microenvironment and Cellular Stress by an international community of researchers. The conference brings together scientists to discuss different cellular and animal models of tumor microenvironment study and identify common pathways that are candidates for therapeutic intervention; stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology (e.g., HIF regulation) and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery; and critically evaluate novel targets for imaging or therapeutic intervention that would be of use to the tumor microenvironment community and pharmaceutical industry.
Автор: Gianfranco Baronzio; Giammaria Fiorentini; Christo Название: Cancer Microenvironment and Therapeutic Implications ISBN: 1402095759 ISBN-13(EAN): 9781402095757 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Explores cancer micro environments and host interactions. This book is suitable for clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees).
Автор: Baronzio Название: Cancer Microenvironment and Therapeutic Implications ISBN: 9048181607 ISBN-13(EAN): 9789048181605 Издательство: Springer Рейтинг: Цена: 139310.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book examines cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic.
Автор: Rejniak Название: Systems Biology of Tumor Microenvironment ISBN: 3319420216 ISBN-13(EAN): 9783319420219 Издательство: Springer Рейтинг: Цена: 148020.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology.
Автор: Aref Название: Ex Vivo Engineering of the Tumor Microenvironment ISBN: 3319453955 ISBN-13(EAN): 9783319453958 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo. Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time.
Казахстан, 010000 г. Астана, проспект Туран 43/5, НП2 (офис 2) ТОО "Логобук" Тел:+7 707 857-29-98 ,+7(7172) 65-23-70 www.logobook.kz
