Expression Profiling in Neuroscience, Karamanos Yannis

Автор: Haines Duane E.
Название: Fundamental Neuroscience for Basic and Clinical Applications
ISBN: 0323396321 ISBN-13(EAN): 9780323396325
Издательство: Elsevier Science
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Цена: 86450.00 T
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Using a rigorous yet clinically-focused approach, Fundamental Neuroscience for Basic and Clinical Applications, 5th Edition, covers the fundamental neuroscience information needed for coursework, exams, and beyond. It integrates neuroanatomy, pharmacology, and physiology, and offers a full section devoted to systems neurobiology, helping you comprehend and retain the complex material you need to know.

• Highlights clinical content in blue throughout the text, helping you focus on what you need to know in the clinical environment.

• Presents thoroughly updated information in every chapter, with an emphasis on new clinical thinking as related to the brain and systems neurobiology.
• Features hundreds of correlated state-of-the-art imaging examples, anatomical diagrams, and histology photos - nearly half are new or improved for this edition.
• Pays special attention to the correct use of clinical and anatomical terminology, and provides new clinical text and clinical-anatomical correlations.

Автор: Merchant
Название: Revival: Pharmacological Regulation of Gene Expression in the CNS Towards an Understanding of Basal Ganglial Functions (1996)
ISBN: 1138561126 ISBN-13(EAN): 9781138561120
Издательство: Taylor&Francis
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Цена: 45930.00 T
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Описание: This book focuses on dopamine-mediated regulation of gene expression within the striatum and associated regions of the central nervous system. It is an excellent review of experimental data on interactions between neuronal systems at systemic, cellular, and molecular levels. Each of the chapters, written by the world's leading scientists, provides an understanding of anatomy, neurochemistry, and cellular and molecular effects. Such an understanding sheds light on the pathophysiology of central disorders involving the basal ganglia and leads to new approaches for the treatment of diseases such as Parkinson's disease and schizophrenia, and also addictions to psychostimulants such as cocaine and amphetamines.

Автор: Roger A. Barker, Francesca Cicchetti, Emma Robinso
Название: Neuroanatomy and Neuroscience at a Glance
ISBN: 1119168414 ISBN-13(EAN): 9781119168416
Издательство: Wiley
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Цена: 32680.00 T
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Описание: Everything you need to know about Neuroanatomy and Neuroscience at a Glance! Neuroanatomy and Neuroscience at a Glance is a highly illustrated, quick reference guide to the anatomy, biochemistry, physiology and pharmacology of the human nervous system.

Автор: Thompson Evan
Название: Waking, Dreaming, Being: Self and Consciousness in Neuroscience, Meditation, and Philosophy
ISBN: 0231136951 ISBN-13(EAN): 9780231136952
Издательство: Wiley
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Цена: 20050.00 T
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Описание: Cognitive science joins with Asian contemplative traditions and philosophy to bring revolutionary meaning to the human experience.

Автор: Dale Purves et all, editors
Название: Neuroscience
ISBN: 160535841X ISBN-13(EAN): 9781605358413
Издательство: Oxford Academ
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Цена: 192180.00 T
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Описание: For over 25 years, Purves Neuroscience has been the most comprehensive and clearly written neuroscience textbook on the market. This level of excellence continues in the 6th Edition, with a balance of animal, human, and clinical studies that discuss the dynamic field of neuroscience from cellular signaling to cognitive function.

Автор: Das Manas, Baugh Lee
Название: Medical Neuroscience Q&A
ISBN: 1626235376 ISBN-13(EAN): 9781626235373
Издательство: Thieme Verlagsgruppe
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Цена: 49540.00 T
Наличие на складе: Нет в наличии.
Описание:

Ensure readiness for the USMLE(R) or any other high-stakes exam covering neuroscience

Thieme Test Prep for the USMLE(R) Medical Neuroscience by Manas Das and Lee Baugh fills a void in available board prep materials with its focus on neuroscience. Readers will learn to recall, analyze, integrate, and apply biochemical and molecular biological knowledge to solve clinical problems.

Key Highlights

• Approximately 520 USMLE(R)-style multiple choice questions on neuroscience, classified as easy, moderate, and difficult, with detailed explanations
• Questions cover clinical neurology as well as basics of neuroscience such as development, structure, and function
• Chapters are organized based on neuroanatomical structure and systems, from the spinal cord to the automatic nervous system
• Neuroimaging section and final exam chapter are invaluable tools for students to utilize before the boards
• Questions begin with a clinical vignette, and approximately 35% are image-based, mirroring the USMLE(R) format

This essential resource will help you assess your knowledge and fully prepare for the USMLE(R) Step 1 or COMLEX Level 1 exam.

Be prepared for your board exam with the Thieme Test Prep for the USMLE(R) series

• Das: Histology and Embryology Q&A
• Fontes and McCarthy: Medical Biochemistry
• Hankin et al: Clinical Anatomy Q&A
• Harriott et al: Medical Microbiology and Immunology Q&A
• Kemp and Brown: Pathology Q&A
• Waite and Sheakley: Medical Physiology Q&A

Visit www.thieme.com/testprep to learn more about our online board review question bank.

Автор: Hernando Ombao, Martin Lindquist, Wesley Thompson, John Aston
Название: Handbook of Neuroimaging Data Analysis
ISBN: 0367330695 ISBN-13(EAN): 9780367330699
Издательство: Taylor&Francis
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Цена: 73490.00 T
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Описание: This book explores various state-of-the-art aspects behind the statistical analysis of neuroimaging data. It examines the development of novel statistical approaches to model brain data.

Автор: Fred D. Davis et al (Editors),
Название: Information systems and neuroscience.
ISBN: 3030010864 ISBN-13(EAN): 9783030010867
Издательство: Springer
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Цена: 93160.00 T
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Описание: This book presents the proceedings of the NeuroIS Retreat 2018, June 19-21, Vienna, Austria, reporting on topics at the intersection of Information Systems (IS) research, neurophysiology and the brain sciences.

Автор: Hicham Zegzouti; Said A. Goueli
Название: Kinase Screening and Profiling
ISBN: 1493949233 ISBN-13(EAN): 9781493949236
Издательство: Springer
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Цена: 88500.00 T
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Описание:

1. HTRF Kinase Assay Development and Methods in Inhibitor Characterization
Yong Jia, Mari Manuia, and Jose Juarez

2. Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening
Clint D. J. Tavares, Ashwini K. Devkota, Kevin N. Dalby, and Eun Jeong Cho

3. Recombinant Kinase Production and Fragment Screening by NMR Spectroscopy
Byeonggu Han and Hee-Chul Ahn

4. Bioluminescence Methods for Assaying Kinases in Quantitative High-Throughput Screening (qHTS) Format Applied to Yes1 Tyrosine Kinase, Glucokinase and PI5P4Kα Lipid Kinase
Mindy I. Davis, Douglas S. Auld, and James Inglese

5. Using Bioluminescent Kinase Profiling Strips to Identify Kinase Inhibitor Selectivity and Promiscuity
Hicham Zegzouti, Jacquelyn Hennek, and Said A. Goueli

6. Measuring Activity of Phosphoinositide Lipid Kinases Using a Bioluminescent ADP-Detecting Assay
Andrew W. Tai and Jolanta Vidugiriene

7. A High-Throughput Radiometric Kinase Assay
Krisna C. Duong-Ly and Jeffrey R. Peterson

8. A High Content Assay to Screen for Modulators of EGFR Function
Christophe Antczak and Hakim Djaballah
9. Monitoring Protein Kinase Expression and Phosphorylation in Cell Lysates with Antibody Microarrays
Hong Zhang, Xiaoqing Shi, and Steven Pelech

10. From Enzyme to Whole Blood: Sequential Screening Procedure for Identification and Evaluation of p38 MAPK Inhibitors
Silke M. Bauer, Jakub M. Kubiak, Ulrich Rothbauer, and Stefan Laufer

11. Genetically Encoded Fluorescent Indicators to Visualize Protein Phosphorylation in Living Cells
Moritoshi Sato and Yoshio Umezawa

12. Characterization of an Engineered Src Kinase to Study Src Signaling and Biology
Leanna R. Gentry, Andrei V. Karginov, Klaus M. Hahn, and Channing J. Der

13. Screening One-Bead-One-Compound Peptide Libraries for Optimal Kinase Substrates
Thi B. Trinh and Dehua Pei

14. Determination of the Substrate Specificity of Protein Kinases with Peptide Micro- and Macroarrays
Shenshen Lai, Dirk F.H. Winkler, Hong Zhang, and Steven Pelech

15. Rapid Identification of Protein Kinase Phosphorylation Site Motifs Using Combinatorial Peptide Libraries
Chad J. Miller and Benjamin E. Turk

Автор: Pawel Ciborowski
Название: Proteomic Profiling and Analytical Chemistry
ISBN: 0444636889 ISBN-13(EAN): 9780444636881
Издательство: Elsevier Science
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Цена: 116780.00 T
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"Proteomic Profiling and Analytical Chemistry: The Crossroads, Second Edition" helps scientists without a strong background in analytical chemistry to understand principles of the multistep proteomic experiment necessary for its successful completion. It also helps researchers who do have an analytical chemistry background to break into the proteomics field. Highlighting points of junction between proteomics and analytical chemistry, this resource links experimental design with analytical measurements, data analysis, and quality control. This targeted point of view will help both biologists and chemists to better understand all components of a complex proteomic study.

The book provides detailed coverage of experimental aspects such as sample preparation, protein extraction and precipitation, gel electrophoresis, microarrays, dynamics of fluorescent dyes, and more. The key feature of this book is a direct link between multistep proteomic strategy and quality control routinely applied in analytical chemistry. This second edition features a new chapter on SWATH-MS, substantial updates to all chapters, including proteomic database search and analytical quantification, expanded discussion of post-hoc statistical tests, and additional content on validation in proteomics.
Covers the analytical consequences of protein and peptide modifications that may have a profound effect on how and what researchers actually measureIncludes practical examples illustrating the importance of problems in quantitation and validation of biomarkersHelps in designing and executing proteomic experiments with sound analytics

Автор: Stephan A. Sieber
Название: Activity-Based Protein Profiling
ISBN: 3642448313 ISBN-13(EAN): 9783642448317
Издательство: Springer
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Цена: 243800.00 T
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Описание: SieberActivity-Based Protein Profiling for Natural Product Target Discovery, by Joanna Krysiak und Rolf BreinbauerPhotoaffinity Labeling in Activity-Based Protein Profiling, by Paul P. TateFunctional Analysis of Protein Targets by Metabolomic Approaches, by Yun-Gon Kim und Alan Saghatelian

Автор: Mathias Munschauer
Название: High-Resolution Profiling of Protein-RNA Interactions
ISBN: 3319162527 ISBN-13(EAN): 9783319162522
Издательство: Springer
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Цена: 121110.00 T
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Описание: The work reported in this book represents an excellent example of how creative experimentation and technology development, complemented by computational data analysis, can yield important insights that further our understanding of biological entities from a systems perspective. The book describes how the study of a single RNA-binding protein and its interaction sites led to the development of the novel ‘protein occupancy profiling’ technology that for the first time captured the mRNA sequence space contacted by the ensemble of expressed RNA binders. Application of protein occupancy profiling to eukaryotic cells revealed that extensive sequence stretches in 3’ UTRs can be contacted by RBPs and that evolutionary conservation as well as negative selection act on protein-RNA contact sites, suggesting functional importance. Comparative analysis of the RBP-bound sequence space has the potential to unravel putative cis-acting RNA elements without a priori knowledge of the bound regulators. Here, Dr. Munschauer provides a comprehensive introduction to the field of post-transcriptional gene regulation, examines state-of-the-art technologies, and combines the conclusions from several journal articles into a coherent and logical story from the frontiers of systems-biology inspired life science. This thesis, submitted to the Department of Biology, Chemistry and Pharmacy at Freie Universit?t Berlin, was selected as outstanding work by the Berlin Institute for Medical Systems Biology at the Max-Delbrueck Center for Molecular Medicine, Germany.