Drug Targets in Cellular Processes of Cancer: From Nonclinical to Preclinical Models, Tuli Hardeep Singh
Автор: Reddy P N Название: Preclinical Prosthodontics 2Ed ISBN: 8123928866 ISBN-13(EAN): 9788123928869 Издательство: CBS India Рейтинг: Цена: 3440.00 T Наличие на складе: Есть
Автор: Guest Paul C. Название: Clinical and Preclinical Models for Maximizing Healthspan: Methods and Protocols ISBN: 1071604708 ISBN-13(EAN): 9781071604700 Издательство: Springer Рейтинг: Цена: 102480.00 T Наличие на складе: Поставка под заказ. Описание: This book presents a series of protocols in multiple disease areas affected by the aging process along with several methods which have shown progress in nutrient- or intervention-based approaches to maximize the healthspan. Of interest to researchers in the areas of chronic disease, gerontology, physical exercise, and nutrition as well as to clinical scientists, physicians, and pharmacologists, this volume also provides important information on disease mechanisms and novel drug targets as each protocol will be presented in the context of specific chronic diseases or different therapeutic areas. Written for the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Clinical and Preclinical Models for Maximizing Healthspan: Methods and Protocols is an ideal guide for preclinical and clinical researchers working toward the discoveries needed to lead to a world society in which individuals are not only living longer lives but more productive and healthier ones.
Автор: Guest Paul C. Название: Clinical and Preclinical Models for Maximizing Healthspan: Methods and Protocols ISBN: 1071604732 ISBN-13(EAN): 9781071604731 Издательство: Springer Цена: 102480.00 T Наличие на складе: Поставка под заказ. Описание: This book presents a series of protocols in multiple disease areas affected by the aging process along with several methods which have shown progress in nutrient- or intervention-based approaches to maximize the healthspan.
This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the various in-silico techniques, such as molecular docking, virtual screening, pharmacophore modeling, molecular dynamics simulations, and residue interaction networks offers insights into pharmacologically active novel molecular entities. It presents a clear concept of the molecular mechanism of different drug targets and explores methods to help understand drug resistance. In addition, it includes chapters dedicated to natural-product- derived medicines, combinatorial drug discovery, the CryoEM technique for structure-based drug design and big data in drug discovery.
The book offers an invaluable resource for graduate and postgraduate students, as well as for researchers in academic and industrial laboratories working in the areas of chemoinformatics, medicinal and pharmaceutical chemistry and pharmacoinformatics.
Автор: Carrie Markgraf Название: Nonclinical Assessment of Abuse Potential for New Pharmaceuticals ISBN: 0124201725 ISBN-13(EAN): 9780124201729 Издательство: Elsevier Science Рейтинг: Цена: 116780.00 T Наличие на складе: Невозможна поставка. Описание: Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples of when you should use these alternatives. Case histories are provided at the end of the book to show how the data generated from the animal models play a pivitol role in the submission package for a new drug. By incorporating all of this information into one book, Nonclinical Assessment of Abuse Potential for New Pharmaceuticals is your single resource for everything you need to know to understand and implement the assessment of abuse liability.
Название: Current Topics in Nonclinical Drug Development ISBN: 0367136279 ISBN-13(EAN): 9780367136277 Издательство: Taylor&Francis Рейтинг: Цена: 183750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The inaugural volume in the Current Topics in Nonclinical Drug Development Series explores the critical issues and current topics in nonclinical drug development. The book will aid toxicologists, toxicologic pathologists, regulators, and study directors, dealing with issues in study design, evaluation of findings, and presentation of data.
Автор: Faqi, Ali S. Название: A Comprehensive Guide to Toxicology in Nonclinical Drug Developme ISBN: 0128036206 ISBN-13(EAN): 9780128036204 Издательство: Elsevier Science Рейтинг: Цена: 193130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more.
Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.
Автор: Joerg Bluemel Название: The Nonhuman Primate in Nonclinical Drug Development and Safety A ISBN: 0124171443 ISBN-13(EAN): 9780124171442 Издательство: Elsevier Science Рейтинг: Цена: 140360.00 T Наличие на складе: Невозможна поставка. Описание: The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area.
Автор: Brock Название: The Role of the Study Director in Nonclinical Studies - Pharmaceuticals, Chemicals, Medical Devices, and Pesticides ISBN: 1118370392 ISBN-13(EAN): 9781118370391 Издательство: Wiley Рейтинг: Цена: 113990.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A single-source reference with a broad and holistic overview of nonclinical studies, this book offers critical training material and describes regulations of nonclinical testing through guidelines, models, case studies, practical examples, and worldwide perspectives.
How Physicians Can Leverage Their Clinical Skills to Transition to Another Career.
By the time they realize their career in clinical medicine isn't everything they thought it would be, many physicians believe they're too invested in their trade to turn back now. Feeling burned out, disengaged, unfulfilled or burdened by high student debt or compensation incommensurate with the demands of their job, they may feel trapped, without options and with nowhere to turn.
In her book, 50 NONCLINICAL CAREERS FOR PHYSICIANS: FULFILLING, MEANINGFUL, and LUCRATIVE ALTERNATIVES TO DIRECT PATIENT CARE, preventive medicine physician Sylvie Stacy offers physicians an escape from that bleak "trap" by identifying numerous nonclinical career options that could align with their skillsets and individual financial situation.
While providing an escape from the stressors of clinical medicine, the book also allays much of the potential guilt associated with "selling out" their chosen profession or abandoning patients by explaining how each physician's training and talents directly translate to patient care outside of clinical medicine.
The value of 50 NONCLINICAL CAREERS FOR PHYSICIANS is in its actionable advice, including how to market yourself in job applications and interviews, and the abundance of detail it provides - including responsibilities, range of compensation and stress levels - to help readers decide which alternative career is the best fit for them. And while other authors encourage physicians to start their own business, Stacy focuses on full-time positions that don't require the reader to begin their own consulting business or find their own clients.
Автор: Liu Название: Biosimilars of Monoclonal Antibodies: A Practical Guide to Manufacturing, Preclinical, and Clinical Development ISBN: 1118662318 ISBN-13(EAN): 9781118662311 Издательство: Wiley Рейтинг: Цена: 171020.00 T Наличие на складе: Поставка под заказ. Описание: Addressing a significant need by describing the science and process involved to develop biosimilars of monoclonal antibody (mAb) drugs, this book covers all aspects of biosimilar development: preclinical, clinical, regulatory, manufacturing.
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