From Biofiltration to Promising Options in Gaseous Fluxes Biotreatment: Recent Developments, New Trends, Advances, and Opportunities provides an overview on the biological tools used for the treatment of the gaseous fluxes, with emphasis on traditional and perspective options, opening new horizons for research and implementation in practice. It is known that air pollution is an emergent global issue and a priority within the international environmental programs. Moreover, technologies based on biological methods are significantly contributing to the sustainable development concept. Thus this book provides tools for solving air pollution issues in a sustainable manner. These issues can be solved at different levels (e.g., end-of-pipe gaseous streams, indoor/outdoor air, closed environments), which can be approached by the different biotechniques presented in the book, from classical biofiltration techniques (part 1) to phytotreatment and microalgae-based techniques (part 2). Although all options have their particularities that make them special for certain applications, a special attention is drawn to the potential of the last one, which offers multiple possibilities for biomass valorization. Scientists from worldwide with relevant experience in their field have been contributed to the development of this book.
Автор: Decker, Michael Название: Design of Hybrid Molecules for Drug Development ISBN: 0081010117 ISBN-13(EAN): 9780081010112 Издательство: Elsevier Science Рейтинг: Цена: 162820.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed.
Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria.
With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders.
Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes
Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied
Compares the advantages and disadvantages of these compounds
Includes the very latest developments, such as photoactivatable and photo-responsive drugs
Автор: Valdir Cechinel Filho Название: Natural Products as Source of Molecules with Therapeutic Potential ISBN: 3030005445 ISBN-13(EAN): 9783030005443 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field. It also provides a detailed overview of the strategies used to research and develop these drugs. Respected experts explore issues involved in the production chain and when looking for new medicinal agents, including aspects such as therapeutic potential, functional foods, ethnopharmacology, metabolomics, virtual screening and regulatory scenarios. Further, the book describes strategic methods of isolation and characterization of active principles, biological assays, biotechnology of plants, synthesis, clinical trials and the use of tools to identity active principles.
Автор: Allen C Templeton; Stephen R. Byrn; Roy J Haskell; Название: Discovering and Developing Molecules with Optimal Drug-Like Properties ISBN: 1493913980 ISBN-13(EAN): 9781493913985 Издательство: Springer Рейтинг: Цена: 174150.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: It also examines the detection, characterization, and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state properties and critical development parameters such as solubility and stability.
Автор: Sharpe Название: Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules ISBN: 3319390244 ISBN-13(EAN): 9783319390246 Издательство: Springer Рейтинг: Цена: 130610.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials – the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of 'steroid-like' natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis.
Автор: Allen C Templeton; Stephen R. Byrn; Roy J Haskell; Название: Discovering and Developing Molecules with Optimal Drug-Like Properties ISBN: 1493948601 ISBN-13(EAN): 9781493948604 Издательство: Springer Рейтинг: Цена: 139310.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: It also examines the detection, characterization, and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state properties and critical development parameters such as solubility and stability.
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