Natural Products as Source of Molecules with Therapeutic Potential, Valdir Cechinel Filho

Автор: K. D. Rainsford; M. C. Powanda; M. W. Whitehouse
Название: Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases
ISBN: 3034809263 ISBN-13(EAN): 9783034809269
Издательство: Springer
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Цена: 139750.00 T
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Описание: In recent years there have been a number of significant developments of natural products for the treatment of rheumatic diseases, pain and gastro-intestinal ulcers and inflammation. The volume covers some of these novel developments of natural products which are of current and future interest as therapies for the above-mentioned conditions. Most available volumes cover a wide range of biological and technicological aspects of natural products and their discovery, some involving synthesis and properties of chemical compounds. The difference in this volume is that the natural products have a focus on their therapeutic effects on pain, arthritic and gastrointestinal diseases. Some of the natural products covered are either at the experimental stage of development while others are well-established clinically-used products. Each has its own unique place in therapy.

Автор: Jeroen Declercq, J.W.M. Creemers
Название: Therapeutic Potential of Furin Inhibition: An Evaluation Using A Conditional Furin Knockout Mouse Model
ISBN: 1615045252 ISBN-13(EAN): 9781615045259
Издательство: Mare Nostrum (Eurospan)
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Цена: 41580.00 T
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Описание: The proprotein convertase Furin is a serine endoprotease which cleaves protein precursors carboxyterminal of basic residues in motifs such as Arg–X–X–Arg and Lys/Arg–Arg. Cleavage usually results in activation of the proprotein but can also inactivate or modify the activity. Therefore, it is not surprising that it plays a major role in many physiological processes and pathologies, including cancer. The other proprotein convertases belonging to the same family, PC1/3, PC2, PACE4, PC4, PC5/6, and PC7, cleave at similar cleavage sites and provide partial redundancy. To unravel the specific role of Furin in vivo, knockout mouse models have been generated. Furin null mice die between e10.5 and e11.5 due to severe ventral closure defects and the failure of the heart tube to fuse and undergo looping morphogenesis. Therefore, a conditional Furin knockout mouse was generated to investigate the role of Furin in specific organs, such as pancreas, liver, T-cells, endothelial cells, and salivary glands, resulting in a severe or mild phenotype depending on the organ investigated. Partial or complete ablation of the Fur gene in salivary gland tumors significantly delayed tumorigenesis in mice. Therefore, Furin inhibition might be considered as a possible therapeutic strategy to treat certain pathologies, such as cancer.

Автор: Alexandre Sauvage, Maxime Levy
Название: Dexamethasone: Therapeutic Uses, Mechanism of Action & Potential Side Effects
ISBN: 1628084057 ISBN-13(EAN): 9781628084054
Издательство: Nova Science
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Цена: 205910.00 T
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Описание: Dexamethasone is a potent, long-term acting synthetic glucocorticoid class of steroid drugs that have anti-inflammatory and immunosuppressant properties. The authors in this book discuss the therapeutic uses, mechanisms of action and potential side effects of dexamethasone. Topics include dexamethasone for the treatment of meconium aspiration syndrome (MAS); dexamethasone effects in hyperinfection syndrome due to strongyloidiasis; dexamethasone use in retinal disease and anti-tumour activities; perioperative uses of dexamethasone; comparison between cortisol and dexamethasone negative feed-back action in humans; the effect of dexamethasone on parathyroid hormone-related protein expression by oral cancer cells; and the effects of dexamethasone on the proliferation and differentiation of osteoblasts.

Автор: Vsevolod V. Gurevich
Название: Arrestins - Pharmacology and Therapeutic Potential
ISBN: 3642411983 ISBN-13(EAN): 9783642411984
Издательство: Springer
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Цена: 287330.00 T
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Описание: This volume in Springer`s authoritative series on experimental pharmacology covers the molecular mechanisms and therapeutic implications of arrestin-mediated signaling, including the potential of re-engineered signaling proteins in the field of gene therapy.

Автор: Richard M. Epand
Название: Host Defense Peptides and Their Potential as Therapeutic Agents
ISBN: 3319329472 ISBN-13(EAN): 9783319329475
Издательство: Springer
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Цена: 148020.00 T
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Описание: This book offers an overview of our current understanding of host defense peptides and their potential for clinical applications as well as some of the obstacles to this.

Автор: Dean J Pierce
Название: Protein Kinase C: Emerging Roles and Therapeutic Potential
ISBN: 1536132101 ISBN-13(EAN): 9781536132106
Издательство: Nova Science
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Цена: 103480.00 T
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Описание: In this compilation, the authors review the structural basis of PKC isozymes and focus on the C1 domain, as well as the plausible binding mechanisms of its activators. Additionally, the recent molecular dynamics simulation studies of how phorbol esters or bryostatin bind to the activator pocket are described and some of the key amino acid residues recently identified as important for activator binding are investigated. The following chapter focuses on the expression pattern and function of PKCα in cancer cells, and newly emerging PKCα-targeted cancer therapies. PKCα acts directly and/or indirectly in various signaling mechanisms in cancer cells, including proliferation, survival, invasion, migration, apoptosis and drug resistance. A final review is provided which dissects the crosstalk between p53 and PKCδ in the context of apoptotic cell death and cancer therapy. PKCδ is implicated in a transcriptional regulation of the p53 tumor suppressor that is critical for cell cycle arrest and apoptosis in response to DNA damage.

Автор: Sidney Cohen
Название: The Therapeutic Potential of Marihuana
ISBN: 1461342880 ISBN-13(EAN): 9781461342885
Издательство: Springer
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Цена: 113190.00 T
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Описание: At the present time, a number of areas of usefulness have been investigated, with some showing greater promise than others. It seemed worthwhile to bring together the investigators working in a wide variety of disciplines who had in common their research activities in the therapeutic aspects of the cannabinoids and related synthetic compounds.

Автор: Neville Vassallo
Название: Natural Compounds as Therapeutic Agents for Amyloidogenic Diseases
ISBN: 3319183648 ISBN-13(EAN): 9783319183640
Издательство: Springer
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Цена: 130430.00 T
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Описание: This edited volume concerns a group of devastating neurological disorders that share a common pathological mechanism, namely the aggregation and deposition of insoluble, proteinaceous lesions, termed ‘amyloid’. Examples of cerebral amyloid disorders include common neurodegenerative diseases like Alzheimer’s disease-related dementia and Parkinson’s disease, as well as other less prevalent conditions like Huntington’s disease, cerebral amyloid angiopathy and the transmissible prion disorders. A disease-modifying therapeutic agent is still lacking for all these diseases, and there are no approved therapies that target amyloid formation directly. Nevertheless, a large and complex group of natural aromatic compounds known as polyphenols are rapidly emerging as potentially potent anti-amyloidogenic agents. This book collectively presents a considerable body of experimental and epidemiological evidence from peer-reviewed scientific publications that support a role for natural compounds and herbal extracts in the chemoprevention and therapy of amyloidogenic disorders. Each contribution is written by scientific experts in the relevant field; chapters are devoted to Mediterranean diet and olive oil phenols, traditional Chinese medicine, herbal extracts, polyphenols (with a particular emphasis on epigallocatechin-3-gallate) and bi-flavonoids, amongst others. The topic of this book is relevant to a wide audience, from academia and university students in the biological and chemical sciences, to physicians and allied health professionals, as well as people working in the nutraceutical industry.

Автор: Rocio Campos–Vega, B. Dave Oomah, Hayde Azeneth Vergara–Castaneda
Название: Food Wastes and By–products: Nutraceutical and Health Potential
ISBN: 1119534100 ISBN-13(EAN): 9781119534105
Издательство: Wiley
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Цена: 174190.00 T
Наличие на складе: Поставка под заказ.
Описание: Face-to-face diplomacy is the most ubiquitous practice of world politics, seen as essential by leaders, but dismissed as irrelevant by political scientists. Drawing upon social neuroscience and psychology, this book addresses this puzzle to create a theory of face-to-face diplomacy that is relevant for both students and scholars of world politics as well as practitioners and policymakers.

Автор: Vsevolod V. Gurevich
Название: Arrestins - Pharmacology and Therapeutic Potential
ISBN: 3662522993 ISBN-13(EAN): 9783662522998
Издательство: Springer
Рейтинг:
Цена: 287330.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume in Springer`s authoritative series on experimental pharmacology covers the molecular mechanisms and therapeutic implications of arrestin-mediated signaling, including the potential of re-engineered signaling proteins in the field of gene therapy.

Автор: Neville Vassallo
Название: Natural Compounds as Therapeutic Agents for Amyloidogenic Diseases
ISBN: 3319359509 ISBN-13(EAN): 9783319359502
Издательство: Springer
Рейтинг:
Цена: 113180.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Examples of cerebral amyloid disorders include common neurodegenerative diseases like Alzheimer`s disease-related dementia and Parkinson`s disease, as well as other less prevalent conditions like Huntington`s disease, cerebral amyloid angiopathy and the transmissible prion disorders.