Mitochondrial Medicine, DiMauro, Salvatore , Hirano, Michio , Schon, Eri

Автор: Stefan Strack; Yuriy M. Usachev
Название: Techniques to Investigate Mitochondrial Function in Neurons
ISBN: 1493968882 ISBN-13(EAN): 9781493968886
Издательство: Springer
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Цена: 139750.00 T
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Описание:

Neuromethods Preface...
Preface...
Table of Contents...
Contributing Authors...

1. Three-Dimensional Reconstruction of Neuronal Mitochondria by Electron Tomography
Guy Perkins

2. Measuring Mitochondrial Shape with ImageJ
Ronald A. Merrill, Kyle H. Flippo, and Stefan Strack

3. Live Imaging Mitochondrial Transport in Neurons
Meredith M. Course, Chung-Han Hsieh, Pei-I Tsai, Jennifer A. Codding-Bui, Atossa Shaltouki, and Xinnan Wang

4. Techniques to Investigate Bioenergetics of Mitochondria
William I. Sivitz

5. Respirometry in Neurons
Liang Zhang and Eugenia Trushina

6. Measuring ATP in Axons with FRET
Lauren Y. Shields, Bryce A. Mendelsohn, and Ken Nakamura

7. Characterizing Metabolic States using Fluorescence Lifetime Imaging Microscopy (FLIM) of NAD(P)H
Thomas S. Blacker and Michael R. Duchen

8. Techniques for Simultaneous Mitochondrial and Cytosolic Ca2+ Imaging in Neurons
Jacob E. Rysted, Zhihong Lin, and Yuriy M. Usachev

9. Live Imaging of Mitochondrial ROS Production and Dynamic Redox Balance in Neurons
Karolina Can, Sebastian Kьgler, and Michael Mьller

10. Monitoring of Permeability Transition Pore Openings in Isolated Individual Brain Mitochondria
Nickolay Brustovetsky and Tatiana Brustovetsky

11. Examination of Mitochondrial Ion Conductance by Patch Clamp in Intact Neurons and Mitochondrial Membrane Preparations
Elizabeth A. Jonas and Nelli Mnatsakanyan

12. Monitoring of Permeability Transition Pore Openings in Mitochondria of Cultured Neurons
Tatiana Brustovetsky and Nickolay Brustovetsky

13. Protocols for Assessing Mitophagy in Neuronal Cell Lines and Primary Neurons
Ruben K. Dagda and Monica Rice

14. Examining Mitochondrial Function at Synapses In Situ
Gregory T. Macleod and Maxim V. Ivannikov

15. Proteomic Analysis of Neuronal Mitochondria
Kelly L. Stauch and Howard S. Fox

16. Measuring Mitochondrial Pyruvate Oxidation
Lawrence R. Gray, Alix A.J. Rouault, Lalita Oonthonpan, Adam J. Rauckhorst, Julien A. Sebag, and Eric B. Taylor

Название: Clinical mitochondrial medicine
ISBN: 0521132983 ISBN-13(EAN): 9780521132985
Издательство: Cambridge Academ
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Описание: This textbook demystifies mitochondrial disorders, by providing a unique system- and case-based approach relevant for students and clinicians across all specialties. The book provides a fundamental reference text which lays the foundations for practicing physicians to understand and investigate mitochondrial disorders in any setting.

Автор: Amy K. Reeve; Eve M. Simcox; Michael R. Duchen; Do
Название: Mitochondrial Dysfunction in Neurodegenerative Disorders
ISBN: 3319803948 ISBN-13(EAN): 9783319803944
Издательство: Springer
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Цена: 125770.00 T
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Описание: This second edition brings together up-to-date contributionsfrom leaders in the field internationally on the various ways in whichmitochondrial dysfunction contributes to the pathogenesis of neurodegenerativediseases, including Parkinson`s disease, Alzheimer`s disease and multiplesclerosis.

Автор: DePace
Название: Clinical Autonomic and Mitochondrial Disorders
ISBN: 3030170152 ISBN-13(EAN): 9783030170158
Издательство: Springer
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Цена: 79190.00 T
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Описание: This book establishes and specifies a rigorously scientific and clinically valid basis for nonpharmaceutical approaches to many common diseases and disorders found in clinical settings.

Автор: Mancuso
Название: Diagnosis and Management of Mitochondrial Disorders
ISBN: 3030055167 ISBN-13(EAN): 9783030055165
Издательство: Springer
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Цена: 121110.00 T
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Описание: This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest.

Автор: Shamim I. Ahmad
Название: Handbook of Mitochondrial Dysfunction
ISBN: 1138336084 ISBN-13(EAN): 9781138336087
Издательство: Taylor&Francis
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Цена: 178640.00 T
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Описание: Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to mitochondria.

Автор: Paul R. Sanberg; Hitoo Nishino; Cesario V. Borlong
Название: Mitochondrial Inhibitors and Neurodegenerative Disorders
ISBN: 089603805X ISBN-13(EAN): 9780896038059
Издательство: Springer
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Цена: 231990.00 T
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Описание: Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function.

Автор: Bingwei Lu
Название: Mitochondrial Dynamics and Neurodegeneration
ISBN: 9400799470 ISBN-13(EAN): 9789400799479
Издательство: Springer
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Цена: 174130.00 T
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Описание: Written by experts, this book offers comprehensive coverage of the mechanisms of mitochondrial dynamics, from basic research on its molecular basis to medical implications, to the direction of future research. Includes numerous color figures and illustrations.

Автор: Reeve
Название: Mitochondrial Dysfunction in Neurodegenerative Disorders
ISBN: 3319286358 ISBN-13(EAN): 9783319286358
Издательство: Springer
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Цена: 125770.00 T
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Описание: This second edition brings together up-to-date contributionsfrom leaders in the field internationally on the various ways in whichmitochondrial dysfunction contributes to the pathogenesis of neurodegenerativediseases, including Parkinson’s disease, Alzheimer’s disease and multiplesclerosis. The reader is guided through the basic functions of mitochondria andthe mechanisms that lead to their dysfunction, and on to the consequences ofthis dysfunction for neuronal function before finishing with the modelling ofthese disorders and discussion of new potential therapeutic targets. Additional chapters have been added to the book to reflectadvances in the field and there are many new contributors and topics, includinghow mitochondria are degraded and the interaction of the mitochondria withpathologically relevant proteins. Mitochondrial Dysfunction in Neurodegenerative Disordersprovides an accessible, authoritative guide to this important area forneurologists; research and clinical neuroscientists; neuropathologists; andresidents with an interest in clinical research.

Автор: Buhlman
Название: Mitochondrial Mechanisms of Degeneration and Repair in Parkinson`s Disease
ISBN: 3319421379 ISBN-13(EAN): 9783319421377
Издательство: Springer
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Цена: 158380.00 T
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Описание: This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.