Buhlman Mitochondrial Mechanisms of Degeneration and Repair in Parkinson`s Disease 9783319421377

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Автор: Buhlman
Название: Mitochondrial Mechanisms of Degeneration and Repair in Parkinson`s Disease
ISBN: 9783319421377
Издательство: Springer
Классификация:

Неврология и клиническая нейрофизиология

Гериатрия

Науки о жизни (медико-биологические): общие вопросы

Нейронауки

ISBN-10: 3319421379
Обложка/Формат: Hardback
Страницы: 275
Вес: 0.60 кг.
Дата издания: 2016
Язык: English
Издание: 1st ed. 2016
Иллюстрации: 23 tables, color; 23 illustrations, color; 5 illustrations, black and white; xii, 275 p. 28 illus., 23 illus. in color.
Размер: 234 x 156 x 18
Читательская аудитория: Professional & vocational
Основная тема: Biomedicine
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Описание: This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.
Дополнительное описание: Mitochondrial ROS and Apoptosis.- Dopamine Metabolism and Reactive Oxygen Species Production.- The Consequences of Damaged Mitochondrial DNA.- The role of chronic inflammation in the etiology of Parkinson’s disease.- Ion-Catalyzed Reactive Oxygen Species

Mitochondrial Mechanisms of Degeneration and Repair in Parkinson`s Disease, Buhlman