Molecular and Cellular Physiology of Neurons, Second Edition, Fain Gordon L.
Автор: Wulfram Gerstner Название: Spiking Neuron Models ISBN: 0521890799 ISBN-13(EAN): 9780521890793 Издательство: Cambridge Academ Рейтинг: Цена: 69690.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Aimed at courses in computational neuroscience, theoretical biology, biophysics, or neural networks, this 2002 text will suit students of physics, mathematics, or computer science, as well as biologists who are interested in mathematical modelling. A large number of worked examples are embedded in the profusely-illustrated text.
Автор: Fried Itzhak, Rutishauser Ueli, Cerf Moran Название: Single Neuron Studies of the Human Brain: Probing Cognition ISBN: 0262027208 ISBN-13(EAN): 9780262027205 Издательство: MIT Press Рейтинг: Цена: 73360.00 T Наличие на складе: Нет в наличии. Описание:
Foundational studies of the activities of spiking neurons in the awake and behaving human brain and the insights they yield into cognitive and clinical phenomena.
In the last decade, the synergistic interaction of neurosurgeons, engineers, and neuroscientists, combined with new technologies, has enabled scientists to study the awake, behaving human brain directly. These developments allow cognitive processes to be characterized at unprecedented resolution: single neuron activity. Direct observation of the human brain has already led to major insights into such aspects of brain function as perception, language, sleep, learning, memory, action, imagery, volition, and consciousness. In this volume, experts document the successes, challenges, and opportunity in an emerging field.
The book presents methodological tutorials, with chapters on such topics as the surgical implantation of electrodes and data analysis techniques; describes novel insights into cognitive functions including memory, decision making, and visual imagery; and discusses insights into diseases such as epilepsy and movement disorders gained from examining single neuron activity. Finally, contributors consider future challenges, questions that are ripe for investigation, and exciting avenues for translational efforts.
Contributors Ralph Adolphs, William S. Anderson, Arjun K. Bansal, Eric J. Behnke, Moran Cerf, Jonathan O. Dostrovsky, Emad N. Eskandar, Tony A. Fields, Itzhak Fried, Hagar Gelbard-Sagiv, C. Rory Goodwin, Clement Hamani, Chris Heller, Mojgan Hodaie, Matthew Howard III, William D. Hutchison, Matias Ison, Hiroto Kawasaki, Christof Koch, Rudiger Kohling, Gabriel Kreiman, Michel Le Van Quyen, Frederick A. Lenz, Andres M. Lozano, Adam N. Mamelak, Clarissa Martinez-Rubio, Florian Mormann, Yuval Nir, George Ojemann, Shaun R. Patel, Sanjay Patra, Linda Philpott, Rodrigo Quian Quiroga, Ian Ross, Ueli Rutishauser, Andreas Schulze-Bonhage, Erin M. Schuman, Demetrio Sierra-Mercado, Richard J. Staba, Nanthia Suthana, William Sutherling, Travis S. Tierney, Giulio Tononi, Oana Tudusciuc, Charles L. Wilson
Автор: Levitan Irwin B., Kaczmarek Leonard K. Название: The Neuron: Cell and Molecular Biology ISBN: 0199773890 ISBN-13(EAN): 9780199773893 Издательство: Oxford Academ Рейтинг: Цена: 116160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The Fourth Edition of The Neuron features newly updated chapters and scores of full-color figures, making it an ideal first course in the cell and molecular biology of nerve cells.
Автор: D`Andrea Michael R. Название: Bursting Neurons and Fading Memories ISBN: 0128019794 ISBN-13(EAN): 9780128019795 Издательство: Elsevier Science Рейтинг: Цена: 53890.00 T Наличие на складе: Невозможна поставка. Описание:
Advances in Alzheimer's disease (AD) research have been challenging and without major breakthroughs in understanding its pathological basis. The reigning hypothesis suggests AD is the result of extracellular amyloid deposition that seed to form amyloid plaques, which then grow and kill neighboring neurons. However, there are several inconsistencies with this hypothesis, not to mention the inability to show clinical benefit in several failed clinical trials by pharmaceuticals (i.e., from Pfizer, Eli Lilly, etc.), and it is in the field's best interest to explore and test multiple hypotheses for pathology rather than drive the majority of research on this single amyloid theory. Reviewing many scientifically peer-reviewed publications, this book describes the "Inside-Out" hypothesis on how amyloid escapes the circulatory system through a dysfunctional blood-brain barrier to bind to the alpha 7 nicotinic acetylcholine receptor on pyramidal neurons. Over time, excessive amounts of amyloid appear to be internalized, resulting in neuron death and lysis. This simple mechanism readily explains plaque composition, size, shape, and location. Based on the current direction of research in the field, this hypothesis appears years from any research and development.
The clear, compelling, and unifying "Inside-Out" hypothesis of AD is brought to life through a string of scientific publications, synthesizing many known features of disease pathology
A high-level text on AD pathology, and suggestions for progress in a stagnating field
Point-by-point discussion on the issues surrounding the current amyloid cascade, and possible reasons why current clinical trials have failed
Contains high-quality photomicrographs in support of the "Inside-Out" hypothesis using single, double, and triple immunohistochemistry on human AD CNS tissues
Chapters address the need for a unifying plaque nomenclature, the importance of intracellular amyloid, the blood-brain barrier, inflammation, and autoimmunity
Автор: Carnevale Название: The Neurone Book. 2006 ISBN: 0521843219 ISBN-13(EAN): 9780521843218 Издательство: Cambridge Academ Рейтинг: Цена: 116160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The NEURON Book is the authoritative reference on NEURON, a software program used by neuroscientists to create models to study the function of biological neurons and neural networks. Written by the creator of the NEURON program, it teaches readers how to use NEURON without assuming any previous computer-programming knowledge.
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