Nucleic Acid Testing for Human Disease, 

Автор: J?rgen Kjems; Elena Ferapontova; Kurt V. Gothelf
Название: Nucleic Acid Nanotechnology
ISBN: 3662509377 ISBN-13(EAN): 9783662509371
Издательство: Springer
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Описание: This book surveys the intersection of nucleic acid research with nanotechnology, including advances in synthetic modifications, applications in bioengineering, nanoscale design, medicine, genetic analysis, chemistry, molecular biology and material science.

Автор: Sambhara, Dr. Prakash
Название: Nucleic Acid Sensors and Antiviral Immunity
ISBN: 0367445905 ISBN-13(EAN): 9780367445904
Издательство: Taylor&Francis
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Описание: This book presents an account of the detection of nucleic acids in infection and inflammation. It addresses innate antiviral responses in invertebrates and provides an overview of Toll-like receptors in vertebrates. The book also provides an in-depth coverage of nucleic acid sensing pathways.

Автор: G?nter Mayer
Название: Nucleic Acid Aptamers
ISBN: 1493931962 ISBN-13(EAN): 9781493931965
Издательство: Springer
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Описание:

Part I: Selection

1. Selection of Aptamers for Metabolite Sensing and Construction of Optical Nanosensors

Yi Long, Franziska Pfeiffer, Gьnter Mayer, Tine Daa Schr der, Veli Cengiz Цzalp, and Lars Folke Olsen

2. SELEX of Cell-Specific RNA Aptamers

Katharina Berg, Eileen Magbanua, and Ulrich Hahn

3. Developing Aptamers by Cell-Based SELEX

Silvia Catuogno, Carla Lucia Esposito, and Vittorio de Franciscis

4. DNA Aptamer Generation by Genetic Alphabet Expansion SELEX (ExSELEX) Using an Unnatural Base Pair System

Michiko Kimoto, Ken-Ichiro Matsunaga, and Ichiro Hirao

5. Capillary Electrophoresis for the Selection of DNA Aptamers Recognizing Activated Protein C

Nasim Shahidi Hamedani and Jens Mьller

6. Preparation of SELEX Samples for Next-Generation Sequencing

Fabian Tolle and Gьnter Mayer

7. Next Generation Analysis of Deep Sequencing Data: Bringing Light into the Black Box of SELEX Experiments

Michael Blank

Part II: Characterization

8. Aptamer Binding Studies Using MicroScale Thermophoresis

Dennis Breitsprecher, Nina Schlinck, David Witte, Stefan Duhr, Philipp Baaske, and Thomas Schubert

9. Label-Free Determination of the Dissociation Constant of Small Molecule-Aptamer Interaction by Isothermal Titration Calorimetry

Marc Vogel and Beatrix Suess

10. Applications of Aptamers in Flow and Imaging Cytometry

Isis C. Nascimento, Arthur A. Nery, Vinicius Bassaneze, Josй E. Krieger, and Henning Ulrich

11. In Vitro and In Vivo Imaging of Fluorescent Aptamers

Ioanna Thйodorou, Nam Nguyen Quang, Karine Gombert, Benoit Thйzй, Benoit Lelandais, and Frйdйric Ducongй

12. Crystallographic Pursuit of a Protein-RNA Aptamer Complex

John J.G. Tesmer

Part III: Application

13. Voltammetric Aptasensor Based on Magnetic Beads Assay for Detection of Human Activated Protein C

Arzum Erdem, Gulsah Congur, and Ece Eksin

14. Apta-PCR

Alessandro Pinto, Pedro Nadal Polo, Marketa Svobodova, Teresa Mairal Lerga, and Ciara K. O'Sullivan

15. Aptamer-Based Enzyme-Capture-Assay for Measurement of Plasma Thrombin Levels

Jens Mьller, Tobias Becher, Gьnter Mayer, and Bernd Pцtzsch

16. Application of Aptamers in Histopathology

Sarah Shigdar, Li Lv, Lifen Wang, and Wei Duan

17. Aptamer Stainings for Super-Resolution Microscopy

Maria Angela Gomes de Castro, Burkhard Rammner, and Felipe Opazo

18. Synthesis and Characterization of Aptamer Targeted SNALPs for the Delivery of siRNA

Samantha E. Wilner and Matthew Levy

19. Screening of Genetic Switches Based on the Twister Ribozyme Motif

Michele Felletti, Benedikt Klauser, and Jцrg S. Hartig

Автор: Marx
Название: Molecular Beacons: Signalling Nucleic Acid Probes, Methods, and Protocols
ISBN: 1617377260 ISBN-13(EAN): 9781617377266
Издательство: Springer
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Описание: From probe design to applications in clinical settings, this book provides a diverse set of instructive examples, guided by experts in the field who offer easy-to-follow experimentals.

Название: Handbook of Nucleic Acid Purification
ISBN: 1138113875 ISBN-13(EAN): 9781138113879
Издательство: Taylor&Francis
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An Indispensable Roadmap for Nucleic Acid Preparation

Автор: Dmitry M. Kolpashchikov (Editor), Yulia V. Gerasim
Название: Nucleic Acid Detection: Methods and Protocols (Methods in Molecular Biology)
ISBN: 1627035346 ISBN-13(EAN): 9781627035347
Издательство: Springer
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Цена: 111790.00 T
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Описание: This Methods in Molecular Biology book details approaches for the detection of DNA and RNA including recovery of trace amounts of DNA for amplification and analysis, new qPCR chemistries, step-by-step, reproducible protocols, materials lists, tips and more.

Автор: H. Ursprung
Название: Nucleic Acid Hybridization in the Study of Cell Differentiation
ISBN: 3662222450 ISBN-13(EAN): 9783662222454
Издательство: Springer
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Цена: 46570.00 T
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Описание: The restrictions on base pairing- A pairing with T (U), and G pairing with C - in nature assures the fidelity of replication of DNA in cell division, and of transcription.

Автор: Vanpouille-Box, Claire
Название: Nucleic Acid Sensing and Immunity, Part A
ISBN: 0128159790 ISBN-13(EAN): 9780128159798
Издательство: Elsevier Science
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Цена: 162820.00 T
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Nucleic Acid Sensing and Immunity - PART A, Volume 344, provides a comprehensive overview of the nucleic acid machinery, from plants to mammalians, as well as their regulation. Specific chapters in this updated release include Molecular bases of discrimination between self from non-self nucleic acids, Intracellular RNA sensing in mammalian cells, Nuclear DNA damage and nucleic acid sensing, Negative regulation of nucleic acid sensing, Dendritic cell responses to exogenous nucleic acids, Activating the nucleic acid-sensing machinery for anticancer immunity, and Nucleic acid sensing and inflammasomes, amongst other topics.

Автор: Vanpouille-Box, Claire
Название: Nucleic Acid Sensing and Immunity - PART B
ISBN: 0128159812 ISBN-13(EAN): 9780128159811
Издательство: Elsevier Science
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Nucleic Acid Sensing and Immunity - PART B, Volume 345 gives a comprehensive overview of the nucleic acid machinery, from plants to mammalians, along with their regulation. Chapters in this updated volume include Nucleic acids sensing in allergic disorders, Nucleic acids sensing in autoimmune disorders, Nucleic acid sensing in inflammatory disorders, Viral nucleic acid sensing inflammasomes in intestinal host defense, Genome damage sensing leads to tissue homeostasis in Drosophila, Nucleic acids sensing in plants, Nucleic Acid sensing in invertebrates, amongst other topics.

Название: Methods for Studying Nucleic Acid/Drug Interactions
ISBN: 1138382035 ISBN-13(EAN): 9781138382039
Издательство: Taylor&Francis
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Since most therapeutic efforts have been predominantly focused on pharmaceuticals that target proteins, there is an unmet need to develop drugs that intercept cellular pathways that critically involve nucleic acids. Progress in the discovery of nucleic acid binding drugs naturally relies on the availability of analytical methods that assess the efficacy and nature of interactions between nucleic acids and their putative ligands. This progress can benefit tremendously from new methods that probe nucleic acid/ligand interactions both rapidly and quantitatively.

A variety of novel methods for these studies have emerged in recent years, and Methods for Studying DNA/Drug Interactions highlights new and non-conventional methods for exploring nucleic acid/ligand interactions. Designed to present drug-developing companies with a survey of possible future techniques, the book compares their drawbacks and advantages with respect to commonly used tools. Perhaps more importantly, this book was written to inspire young scientists to continue to advance these methods into fruition, especially in light of current capabilities for assay miniaturization and enhanced sensitivity using microfluidics and nanomaterials.

Автор: Swaminathan
Название: Circulating Nucleic Acids in Plasma and Serum IV: Annals of the New York Academy of Sciences Volume 1075
ISBN: 157331627X ISBN-13(EAN): 9781573316279
Издательство: Wiley
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Описание: An accurate, inexpensive, and noninvasive method for the early diagnosis of cancer has been something of a holy grail among cancer researchers, but until recently a method meeting all three criteria has been elusive.

Автор: Fritz Eckstein; David M. J. Lilley
Название: Nucleic Acids and Molecular Biology
ISBN: 3642837115 ISBN-13(EAN): 9783642837111
Издательство: Springer
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Цена: 121890.00 T
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Описание: A wide range of topics are covered, including articles on nucleic acid structure, through their interactions with proteins to the control of gene expression. Gene transcription is also covered, from the points of view of DNA methylation, mammalian ribosomal and avian lysozyme genes, and the control of transcription in the proto-oncogene c-fos.