Biopharmaceutics and Pharmacokinetics, PL Madan

Автор: Macheras Panos, Iliadis Athanassios
Название: Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics / Homogeneous and Heterogeneous Approaches
ISBN: 0387281789 ISBN-13(EAN): 9780387281780
Издательство: Springer
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Цена: 55850.00 T
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Описание: The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. www.springeronline.com

Автор: Shargel
Название: Applied Biopharmaceutics & Pharmacokinetics
ISBN: 0071240055 ISBN-13(EAN): 9780071240055
Издательство: McGraw-Hill
Цена: 28590.00 T
Наличие на складе: Поставка под заказ.
Описание: The primary emphasis of this book is on the application and understanding of concepts. Basic theoretical discussions of the principles of biopharmaceutics and pharmacokinetics are provided, along with illustrative examples and practice problems and solutions to help the student gain skill in practical problem solving.

Автор: Shargel Leon
Название: Applied Biopharmaceutics & Pharmacokinetics, 7 ed.
ISBN: 0071830936 ISBN-13(EAN): 9780071830935
Издательство: McGraw-Hill
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Цена: 68630.00 T
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Описание: The landmark textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics-now fully updated

Автор: Rescigno Aldo
Название: Foundations of Pharmacokinetics
ISBN: 0306477041 ISBN-13(EAN): 9780306477041
Издательство: Springer
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Цена: 174150.00 T
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Описание: This book is divided into two parts; in the first part the principles and the methods of pharmacokinetics are described in detail, while in the second the main pharmacokinetic parameters are described, giving for each of them the definition, the principal properties, and the methods of determination. An appendix contains the important mathematical instruments used in the main part of the book, namely the operational calculus and the convolution integral. In the second part there is a careful distinction among pharmacokinetic parameters, i.e., parameters that represent a true pharmacokinetic property, model parameters, i.e., parameters that represent a property of a specific model, and incidental parameters, i.e., parameters that represent only the result of a particular experiment. Special care is taken to distinguish between the definition of a parameter, and the properties that derive from that definition; a considerable emphasis is also given to the fact that each method for the determination of a parameter is dependent on the specific model it is based on.

Автор: Panos Macheras; Athanassios Iliadis
Название: Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics
ISBN: 3319275968 ISBN-13(EAN): 9783319275963
Издательство: Springer
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Цена: 111790.00 T
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Описание: The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. This second edition has new information on reaction limited models of dissolution, non binary biopharmaceutic classification system, time varying models, and interface models.

Автор: Krishna, Rajesh
Название: Biopharmaceutics applications in drug development
ISBN: 1441944346 ISBN-13(EAN): 9781441944344
Издательство: Springer
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Цена: 204040.00 T
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Описание: The highly experienced authors here present readers with step-wise, detail-conscious information to develop quality pharmaceuticals. It provides a specific focus on the integration of regulatory considerations and includes case histories highlighting the biopharmaceutics strategies adopted in development of successful drugs.

Автор: Thorsteinn Loftsson
Название: Essential Pharmacokinetics
ISBN: 0128014113 ISBN-13(EAN): 9780128014110
Издательство: Elsevier Science
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Цена: 59890.00 T
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Описание: Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients.

Автор: Andrea Angelini
Название: Voriconazole: Pharmacokinetics, Role in Therapeutic Drug Monitoring & Clinical Outcomes
ISBN: 163463313X ISBN-13(EAN): 9781634633130
Издательство: Nova Science
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Цена: 224920.00 T
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Описание: In the last twenty years, the incidence of invasive fungal infections (IFI) has risen dramatically due to the prolongation of survival of patients with multiple risk factors for fungal infections and due to the increase of infection associated with travel. Moreover IFI in infants admitted to the neonatal intensive care unit are common and often fatal. Amphotericin B was for more than 40 years the gold standard for almost all IFI, but toxicity and resistance, especially of new and emerging pathogens remained important issues. Fluconazole and itraconazole have also the same disadvantage of resistance. After a long period of relative inactivity in the introduction of new antifungals, more recently a few new drugs of already existing classes have been introduced as important agents in the treatment and prevention of IFI. These represent small or large advantages and differences compared with existing available alternative therapy for deep and systemic mycoses. Voriconazole is a second-generation triazole antifungal drug, often prescribed as first-line therapy for candidemia, in non-neutropenic hosts, for invasive pulmonary aspergillosis and as prophylaxis of many systemic mycoses. In-vitro and in-vivo studies showed that voriconazole has broad-spectrum activity against most Candida species, Aspergillus species, fusariosis or scedosporiosis. Voriconazole has non-linear pharmacokinetics and, as substrate and inhibitor of cytochrome P450, it undergoes extensive hepatic metabolism that depends on age, genetic factors, and interactions with other drugs, which may lead to enhanced toxicity of the concomitant medication(s) or ineffective antifungal treatment. This book presents an update on voriconazole research, particularly its pharmacology, microbiology, toxicology, and clinical outcomes in order to optimize its use in daily clinical practice.

Автор: T. Teorell
Название: Pharmacology and Pharmacokinetics
ISBN: 1468420577 ISBN-13(EAN): 9781468420579
Издательство: Springer
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Цена: 113190.00 T
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Описание: As one of the founders of pharmacokinetics, Professor Teorell has made many contributions to the field since he first presented a formal multicompartment model for the analysis of drug action and drug metabolism in 1937 (Teorell, 1937).

Автор: Ronald Carman
Название: Zoledronic Acid: Clinical Uses, Therapeutic Effects and Pharmacokinetics
ISBN: 1633215253 ISBN-13(EAN): 9781633215252
Издательство: Nova Science
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Цена: 257650.00 T
Наличие на складе: Невозможна поставка.
Описание: An Introduction Third Edition 2015. This book describes the principles of the blast furnace process and especially the control of the process. As a starting point, the blast furnace is seen as a simple iron ore smelter, while gradually the physical, chemical and metallurgical background of the blast furnace process is clarified. The book focuses on the control of the blast furnace process with respect to thermal control, gas flow control and casthouse operation. In this book, all essential process details are described and a special focus is on optimization of coal injection. The optimization of the blast furnace process is not only