Estrogen Receptor and Breast Cancer, Xiaoting Zhang

Автор: Xiaoting Zhang
Название: Estrogen Receptor and Breast Cancer
ISBN: 3319993496 ISBN-13(EAN): 9783319993492
Издательство: Springer
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Цена: 158380.00 T
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Описание: The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.

Автор: Yosef Yarden; Moshe Elkabets
Название: Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways
ISBN: 3030098176 ISBN-13(EAN): 9783030098179
Издательство: Springer
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Цена: 139750.00 T
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Описание: This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression. Each chapter will cover a specific group of targets and the cognate drugs, along with molecular modes of innate and evolving resistance.

Автор: Michelina Plateroti; Jacques Samarut
Название: Thyroid Hormone Nuclear Receptor
ISBN: 1493993208 ISBN-13(EAN): 9781493993208
Издательство: Springer
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Цена: 102480.00 T
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Описание: This volume aims to detail the advances in the field of Thyroid hormones (THs), namely T3 and T4, and their nuclear receptor TRs from a conceptual and methodological point of view. Chapters guide readers through a general introduction, TR's engineered mice, human genetics of TRs, control of the hypothalamus-pituitary-thyroid (HPT) axis, the relevance of the local THs production and metabolism and pathological consequences of TH/TR alterations. Non-mammalian models are also presented and discussed. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Thyroid Hormone Nuclear Receptor: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Автор: Zsuzsanna Suba
Название: Estrogen Prevention for Breast Cancer
ISBN: 1624173780 ISBN-13(EAN): 9781624173783
Издательство: Nova Science
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Цена: 178450.00 T
Наличие на складе: Невозможна поставка.
Описание: Assembles an international group of scholars to move beyond the ideas and activities of party leaders who have hitherto received the bulk of historical attention. It illuminates how the Republican Party expanded its regional base, especially in the South, appealed to new constituencies ranging from blue-collar workers to Christian fundamentalists, and enhanced the political appeal of conservatism.

Автор: Jay Schulkin
Название: Medical Decisions, Estrogen and Aging
ISBN: 9048176999 ISBN-13(EAN): 9789048176991
Издательство: Springer
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Цена: 111790.00 T
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Описание: The decision making process that underlies ovarian hormone therapy (HT) is fallible. Thus, the decision for women to go on HT remains controversial. At a time when confusion still permeates the decision making with regard to HT, this book bridges diverse features that surround the decision making concerning HT.

Автор: Kenneth S. Korach; Tim Wintermantel
Название: Tissue-Specific Estrogen Action
ISBN: 3642421032 ISBN-13(EAN): 9783642421037
Издательство: Springer
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Цена: 130590.00 T
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Описание: Current molecular understanding of estrogen action has greatly profited from advances in molecular cell biology. These advances, and their implications for clinical use, were discussed by leading researchers from industry and academia during an international symposium held in Berlin, 1-3 March 2006 and are featured in this volume.

Автор: Christian Behl
Название: Estrogen — Mystery Drug for the Brain?
ISBN: 3709172543 ISBN-13(EAN): 9783709172544
Издательство: Springer
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Цена: 93160.00 T
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Описание: The focus is (1) to describe the biochemical, molecular, and cellular basis of the protective activity of estrogen and (2) to transfer this knowledge into the hospitals by discussing preventive and therapeutic approaches such as estrogen replacement therapy for post-menopausal women.

Автор: Kenneth S. Korach; Alexander Hillisch; Karl Heinri
Название: New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy
ISBN: 3662053888 ISBN-13(EAN): 9783662053881
Издательство: Springer
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Цена: 93160.00 T
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Описание: The evidence that these effects are mediated through the estrogen receptor(s) is based on similar but not always identical phenotypes as observed in experimental animal models of estrogen receptor mutations as well as the single clinical case of an estrogen receptor alpha mutant patient.

Автор: Lee, Daniel
Название: Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer
ISBN: 0323661815 ISBN-13(EAN): 9780323661812
Издательство: Elsevier Science
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Цена: 70730.00 T
Наличие на складе: Невозможна поставка.
Описание:

From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area.

Автор: Martial Ruat
Название: The Smoothened Receptor in Cancer and Regenerative Medicine
ISBN: 3319354027 ISBN-13(EAN): 9783319354026
Издательство: Springer
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Цена: 200260.00 T
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Описание: Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins.- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators.- Receptor modifications in Hedgehog regulation.- Smoothened, stem cell maintenance and brain diseases.- Medulloblastoma, pediatric brain tumors and Smoothened blockade.- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization.- Implications in stem cell maintenance.- Comparison of the crystal structure of Smoothened to known GPCRs structure.

Автор: Martial Ruat
Название: The Smoothened Receptor in Cancer and Regenerative Medicine
ISBN: 3319197541 ISBN-13(EAN): 9783319197548
Издательство: Springer
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Цена: 243800.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins.- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators.- Receptor modifications in Hedgehog regulation.- Smoothened, stem cell maintenance and brain diseases.- Medulloblastoma, pediatric brain tumors and Smoothened blockade.- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization.- Implications in stem cell maintenance.- Comparison of the crystal structure of Smoothened to known GPCRs structure.

Автор: Yosef Yarden; Moshe Elkabets
Название: Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways
ISBN: 3319679309 ISBN-13(EAN): 9783319679303
Издательство: Springer
Рейтинг:
Цена: 149060.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression.