Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer, Lee, Daniel

Автор: Kamilla Swiech; Kelen Cristina Ribeiro Malmegrim;
Название: Chimeric Antigen Receptor T Cells
ISBN: 1071601458 ISBN-13(EAN): 9781071601457
Издательство: Springer
Рейтинг:
Цена: 79190.00 T
Наличие на складе: Поставка под заказ.
Описание: This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell characterization, and quality control. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chimeric Antigen Receptor T Cells: Development and Production aims to be useful in the production of CAR-T cells, especially for therapeutic purposes.

Автор: Hong-Yang Chuang
Название: Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Cancer
ISBN: 3662468476 ISBN-13(EAN): 9783662468470
Издательство: Springer
Рейтинг:
Цена: 74530.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This thesis focuses on the synthesis and vaccine evaluation of the prostate tumor- associated carbohydrate antigen RM2.

Автор: Hayat M.A.
Название: Microscopy, Immunohistochemistry, and Antigen Retrieval Methods / For Light and Electron Microscopy
ISBN: 0306467704 ISBN-13(EAN): 9780306467707
Издательство: Springer
Рейтинг:
Цена: 213360.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Histochemistry deals with the activities of chemical components in cells, and immunohistochemistry addresses the function of cell types in tissue or organs, such as those leading to acceptance or rejection of grafts or organs. This book is a methods volume focusing on antigen retrieval, particularly methods used in disease-related antigens. Because the book is a methods volume and a lab manual, it will have an audience of pathologists, biochemists, and lab technicians.

Автор: Pavel Koldovsky
Название: Tumor Specific Transplantation Antigen
ISBN: 3642885381 ISBN-13(EAN): 9783642885389
Издательство: Springer
Рейтинг:
Цена: 93160.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.

Автор: M.A. Hayat
Название: Microscopy, Immunohistochemistry, and Antigen Retrieval Methods
ISBN: 1475776330 ISBN-13(EAN): 9781475776331
Издательство: Springer
Рейтинг:
Цена: 186330.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Histochemistry deals with the activities of chemical components in cells, and immunohistochemistry addresses the function of cell types in tissue or organs, such as those leading to acceptance or rejection of grafts or organs.

Автор: Martial Ruat
Название: The Smoothened Receptor in Cancer and Regenerative Medicine
ISBN: 3319354027 ISBN-13(EAN): 9783319354026
Издательство: Springer
Рейтинг:
Цена: 200260.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins.- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators.- Receptor modifications in Hedgehog regulation.- Smoothened, stem cell maintenance and brain diseases.- Medulloblastoma, pediatric brain tumors and Smoothened blockade.- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization.- Implications in stem cell maintenance.- Comparison of the crystal structure of Smoothened to known GPCRs structure.

Автор: Xiaoting Zhang
Название: Estrogen Receptor and Breast Cancer
ISBN: 3030075931 ISBN-13(EAN): 9783030075934
Издательство: Springer
Рейтинг:
Цена: 158380.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.

Автор: Martial Ruat
Название: The Smoothened Receptor in Cancer and Regenerative Medicine
ISBN: 3319197541 ISBN-13(EAN): 9783319197548
Издательство: Springer
Рейтинг:
Цена: 243800.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Canonical and non canonical Hedgehog signaling pathways, coupling to G-proteins.- Pharmacochemistry of the Smoothened receptor: Agonists, antagonists, allosteric modulators.- Receptor modifications in Hedgehog regulation.- Smoothened, stem cell maintenance and brain diseases.- Medulloblastoma, pediatric brain tumors and Smoothened blockade.- Role of Smoothened and Hedgehog signaling in angiogenesis, neovascularization.- Implications in stem cell maintenance.- Comparison of the crystal structure of Smoothened to known GPCRs structure.

Автор: Yosef Yarden; Moshe Elkabets
Название: Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways
ISBN: 3319679309 ISBN-13(EAN): 9783319679303
Издательство: Springer
Рейтинг:
Цена: 149060.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression.

Автор: Yosef Yarden; Moshe Elkabets
Название: Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways
ISBN: 3030098176 ISBN-13(EAN): 9783030098179
Издательство: Springer
Рейтинг:
Цена: 139750.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression. Each chapter will cover a specific group of targets and the cognate drugs, along with molecular modes of innate and evolving resistance.

Автор: Xiaoting Zhang
Название: Estrogen Receptor and Breast Cancer
ISBN: 3319993496 ISBN-13(EAN): 9783319993492
Издательство: Springer
Рейтинг:
Цена: 158380.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.

Автор: Chawnshang Chang
Название: Androgens and Androgen Receptor
ISBN: 1461354226 ISBN-13(EAN): 9781461354222
Издательство: Springer
Рейтинг:
Цена: 139750.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.